Results 101 to 110 of about 66,092 (301)

Protein Nitration in Patients with Mitochondrial Diseases

Antioxidants
Mitochondrial diseases are complex disorders caused by nuclear or mitochondrial DNA mutations, leading to oxidative phosphorylation deficiency and excessive production of reactive oxygen species (ROS).
Jomênica B. Livramento, Gabriela S. Rodrigues, Jean Faber, Luis A. de Souza Filho, Felipo V. Moura, Camila D. S. Barros, Wladimir B. V. R. Pinto, Beny Schmidt, Acary S. B. Oliveira, Beatriz H. Kiyomoto, Célia H. Tengan   +10 more
doaj   +1 more source

X-linked Chronic Granulomatous Disease Presenting Clinically as Tuberculosis in a 10-Month-Old Child: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Chronic Granulomatous Disease (CGD) is a rare primary immunodeficiency with an estimated incidence of 1 in 200,000-250,000 live births caused by defects in the Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase complex.
Sahibjot Singh Romana, Uday Pratap Singh, Kanav Goyal, Arnav Jagota   +3 more
doaj   +1 more source

Protein sorting to mitochondria [PDF]

, 1990
According to the endosymbiont hypothesis, mitochondria have lost the autonomy of their prokaryotic ancestors. They have to import most of their proteins from the cytosol because the mitochondrial genome codes for only a small percentage of the ...
Hartl, Franz-Ulrich, Neupert, Walter
core   +1 more source

Elesclomol restores mitochondrial function in genetic models of copper deficiency [PDF]

, 2018
© The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Proceedings of the National Academy of Sciences of the United States of America 115 (2018): 8161-8166,
Boulet, Aren, Chan, Sherine S. L., Chun, Haarin, Gitlin, Jonathan D., Gohil, Vishal M., Kim, Byung-Eun, Latimer, Andrew J., Leary, Scot C., Rahn, Jennifer J., Soma, Shivatheja, Timbalia, Shrishiv A., Vicary, Alison C.   +11 more
core   +1 more source

An elastic segment of the whisker shaft enables coding of the whisking phase via whisker torsion in rats and mice

The Anatomical Record, EarlyView.
An elastic segment was found in the basal part of the whisker shaft in rats and mice. Application of force to the whisker bulb of isolated follicles caused bending and twisting of this segment. Active whisker movements deform this segment, causing whisker shaft deflection and selective activation of mechanoreceptors at different phases of whisking ...
Sebastian Haidarliu, Guy Nelinger, Luka Gantar, Ehud Ahissar, Inbar Saraf‐Sinik   +4 more
wiley   +1 more source

FXR-regulated COX6A2 triggers mitochondrial apoptosis of pancreatic β-cell in type 2 diabetes

Cell Death and Disease
Pancreatic β-cell apoptosis plays a crucial role in the development of type 2 diabetes. Cytochrome c oxidase subunit 6A2 (COX6A2) and Farnesoid X Receptor (FXR) have been identified in pancreatic β-cells, however, whether they are involved in β-cell ...
Lianqi Shao, Xiangchen Kong, Simian Lv, Xingsheng Shu, Xiaosong Ma, Xiaojiao Ai, Dan Yan, Ying Ying   +7 more
doaj   +1 more source

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

, 2013
Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson, Audibert G, Berne RM, Blitzer ML, Boutilier RG, Brown IP, Devlin C, Furukawa K, Hall JE, Heyes MP, Jekabsone A, Lehninger A, Leone AM, Louis CA, Martin Feelisch, Mervyn Singer, Michele Umbrello, Modin A, Munk VC, Pohl U, Rengasamy A, Rengasamy A, Vallance P, Whorton AR   +23 more
core   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source