Results 21 to 30 of about 8,394 (135)

Metabolism of six CYP probe substrates in fetal hepatocytes

ADMET and DMPK, 2016
Cytochrome P-450 (CYP) are the most common drug metabolizing enzymes and are abundantly expressed in liver apart from kidney, lungs, intestine, brain etc. Their expression levels change with physiological conditions and disease states.
Abdul Naveed Shaik, Sandeep Kumar Vishwakarma, Aleem A Khan   +2 more
doaj   +1 more source

Association between genetic polymorphisms of cytochrome P450 2C19 and the risk of cerebral ischemic stroke in Chinese [PDF]

, 2014
BACKGROUND: Cytochrome P450 (CYP) 2C19 is a very important drug metabolizing enzyme. Although the single nucleotide polymorphisms (SNPs) of CYP2C19 G681A and G636A have been suggested that they may increase the incidence of cardiovascular events, the ...
Dongliang Wang, Jizuo Wang, Lin Wang, Ruifa Han, Shuzhen Gu, Xin Li, Yan Sun   +6 more
core   +2 more sources

Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention [PDF]

, 2018
OBJECTIVES: This multicenter pragmatic investigation assessed outcomes following clinical implementation of CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention (PCI).
Alestock, Tameka D., Alsip, Jorge, Anderson, R. David, Ardati, Amer K., Beitelshees, Amber L., Brott, Brigitta C., Brown, Lawrence, Cavallari, Larisa H., Chumnumwat, Supatat, Clare-Salzler, Michael J., Coons, James C., Cooper-DeHoff, Rhonda M., Dave, Chintan V., Denny, Joshua C., Dillon, Chrisly, Duarte, Julio D., Elsey, Amanda R., Empey, Philip E., Gong, Yan, Hamadeh, Issam, Harada, Shuko, Hillegass, William B., Hines, Lindsay, Horenstein, Richard B., Howell, Lucius A., Jeng, Linda J.B., Johnson, Julie A., Kelemen, Mark D., Kimmel, Stephen E., Kreutz, Rolf P., Lee, Craig R., Lee, Y.M., Limdi, Nita A., Magvanjav, Oyunbileg, McDonough, Caitrin W., Montasser, May, Nelson, David R., Nutescu, Edith A., Nwaba, Devon C., Pakyz, Ruth E., Palmer, Kathleen, Peterson, Josh F., Pollin, Toni I., Pratt, Victoria M., Quinn, Alison H., Robinson, Shawn W., Schub, Jamie, Shuldiner, Alan R., Skaar, Todd C., Smith, Donald M., Sriramoju, Vindhya B., Starostik, Petr, Stevenson, James M., Stouffer, George A., Stys, Tomasz P., Varunok, Nicholas, Vesely, Mark R., Voora, Deepak, Wake, Dyson T., Weck, Karen E., Weitzel, Kristin W., Wilke, Russell A., Willig, James, Winterstein, Almut G., Zhao, Richard Y.   +64 more
core   +1 more source

Translational high-dimensional drug Interaction discovery and validation using health record databases and pharmacokinetics models [PDF]

, 2017
Polypharmacy increases the risk of drug-drug interactions (DDI's). Combining epidemiological studies with pharmacokinetic modeling, we detected and evaluated high-dimensional DDI's among thirty frequent drugs.
Chiang, Chien-Wei, Li, Lang, Ning, Xia, Quinney, Sara K., Shen, Li, Wang, Lei, Wang, Xueying, Zhang, Pengyue, Zhang, Shijun   +8 more
core   +1 more source

Feasibility of clinical pharmacist-led CYP2C19 genotyping for patients receiving non-emergent cardiac catheterization in an integrated health system

Pharmacy Practice, 2017
Objective: To assess the feasibility of clinical pharmacist-led CYP2C19 genotype-guided P2Y12 inhibitor antiplatelet drug therapy recommendations to cardiologists in an outpatient cardiology practice.
Johnson SG, Shaw PB, Delate T, Kurz DL, Gregg D, Darnell JC, Aquilante CL   +6 more
doaj   +1 more source

Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study). [PDF]

, 2017
It is well known that the standard doses of a given drug may not have equivalent effects in all patients. To date, the management of depression remains mainly empirical and often poorly evaluated.
Bellivier, F., Besson, M., Calvas, F., Chevret, S., Courtet, P., Cracowski, J.L., Daali, Y., Davani, S., Desmeules, J., Desmidt, T., Doumy, O., Déglon, J., El-Hage, W., Galtier, F., Haesebaert, F., Haffen, E., Heron, K., Holtzmann, J., Le Corvoisier, P., Leboyer, M., Llorca, P.M., Lloret-Linares, C., Molière, F., Montange, D., Morange, S., Nieto, I., Richieri, R.M., Vignaud, P., Yon, L., Yrondi, A.   +29 more
core   +5 more sources

The possibility of selecting optimal antiplatelet therapy in patients with coronary heart disease in terms of CYP2C19 polymorphism [PDF]

Терапевтический архив, 2016
Aim. To estimate whether optimal antiplatelet therapy can be selected in terms of CYP2C19 polymorphism. Subjects and methods. The prospective randomized trial included 124 patients (93 men and 31 women) who were to undergo percutaneous coronary ...
O L Bockeria, Z F Kudzoeva, V A Shvarts, A K Koasari, S A Donakanyan   +4 more
doaj  

Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan [PDF]

, 2016
A list of SNPs that were not found in heterozygous or homozygous variants.
Aisha N. Iskakova, Akbota M. Aitkulova, Aliya A. Romanova, Elena V. Zholdybayeva, Erlan M. Ramanculov, Nurgul S. Sikhayeva   +5 more
core   +5 more sources

Clinical applications of pharmacogenomics [PDF]

, 2017
Indexación: Scopus.Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution ...
Cayún, J.P., Escalante, P., Gallegos, B., Lares-Asseff, I., Meneses, F., Miranda, C., Quiñones, L., Roco, Á., Varela, N., Zaruma-Torres, F.   +9 more
core   +1 more source

TRAF3 Epigenetic Regulation Is Associated With Vascular Recurrence in Patients With Ischemic Stroke [PDF]

, 2016
Clopidogrel is one of the most used antiplatelet drugs in patients with cardiovascular disease. However, 16% to 50% of patients have a high on-clopidogrel platelet reactivity and an increased risk of ischemic events. The pathogenesis of high on-treatment
Carrera, Caty, Cullell, Natalia, Fernandez-Cadenas, Israel, Fontana, Pierre, Gallego-Fabrega, Cristina, Krupinski, Jerzy, Martí-Fàbregas, Joan, Montaner, Joan, Muiño, Elena, Pera, Joanna, Pezzini, Alessandro, Reny, Jean-Luc, Segura, Tomás, Serrano-Heras, Gemma, Slowik, Agnieszka   +14 more
core   +2 more sources