Results 41 to 50 of about 29,283 (148)

Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention [PDF]

, 2018
OBJECTIVES: This multicenter pragmatic investigation assessed outcomes following clinical implementation of CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention (PCI).
Alestock, Tameka D., Alsip, Jorge, Anderson, R. David, Ardati, Amer K., Beitelshees, Amber L., Brott, Brigitta C., Brown, Lawrence, Cavallari, Larisa H., Chumnumwat, Supatat, Clare-Salzler, Michael J., Coons, James C., Cooper-DeHoff, Rhonda M., Dave, Chintan V., Denny, Joshua C., Dillon, Chrisly, Duarte, Julio D., Elsey, Amanda R., Empey, Philip E., Gong, Yan, Hamadeh, Issam, Harada, Shuko, Hillegass, William B., Hines, Lindsay, Horenstein, Richard B., Howell, Lucius A., Jeng, Linda J.B., Johnson, Julie A., Kelemen, Mark D., Kimmel, Stephen E., Kreutz, Rolf P., Lee, Craig R., Lee, Y.M., Limdi, Nita A., Magvanjav, Oyunbileg, McDonough, Caitrin W., Montasser, May, Nelson, David R., Nutescu, Edith A., Nwaba, Devon C., Pakyz, Ruth E., Palmer, Kathleen, Peterson, Josh F., Pollin, Toni I., Pratt, Victoria M., Quinn, Alison H., Robinson, Shawn W., Schub, Jamie, Shuldiner, Alan R., Skaar, Todd C., Smith, Donald M., Sriramoju, Vindhya B., Starostik, Petr, Stevenson, James M., Stouffer, George A., Stys, Tomasz P., Varunok, Nicholas, Vesely, Mark R., Voora, Deepak, Wake, Dyson T., Weck, Karen E., Weitzel, Kristin W., Wilke, Russell A., Willig, James, Winterstein, Almut G., Zhao, Richard Y.   +64 more
core   +1 more source

Functional Imaging of CYP3A4 at Multiple Dimensions Using an AI‐Driven High Performance Fluorogenic Substrate

Small, Volume 21, Issue 17, April 28, 2025.
This study showcases a novel artificial intelligence (AI)‐driven design strategy for constructing highly specific and orally‐active fluorogenic substrates for imaging CYP3A4 in complex biological systems, while NFa emerged as a practical and reliable tool for sensing and imaging of CYP3A4 activity thus facilitating CYP3A4‐associated fundamental ...
Feng Zhang, Lilin Song, Ruixuan Wang, Bei Zhao, Jian Huang, Luling Wu, Yufan Fan, Hong Lin, Zhengtao Jiang, Xiaodi Yang, Hairong Zeng, Xin Yang, Tony D. James, Guangbo Ge   +13 more
wiley   +1 more source

A study of associations of polymorphic variants of cytochrome P-450 system genes and multi-drug resistance gene with the development of druginduced hyperprolactinemia in patients with schizophrenia [PDF]

, 2017
The detection of clinical and biological associations in different alleles and genotypes allows to create the fundament for development methods, which help to identify risk of side-effects in patients with schizophrenia, who received long-term ...
Воронина, Е. Н., Пожидаев, И. В.   +1 more
core  

CYP2C19*2 allele carrier status and coronary in-stent restenosis : is there an association? [PDF]

, 2018
Background and objective: The CYP2C19*2 allele is associated with reduced clopidogrel bioactivation, increasing the risk of complications after percutaneous coronary intervention (PCI), particularly stent thrombosis. Recently published data suggests that
Azzopardi, Lilian M., Barbara, Christopher, Camilleri, Liberato, Fenech, Albert, Wirth, Francesca, Xuereb, Robert G., Zahra, Graziella   +6 more
core   +1 more source

Inhibitory Effect of Antituberculosis Drugs on Human Cytochrome P450-Mediated Activities

Journal of Pharmacological Sciences, 2004
The potential for drug-drug interactions mediated by the inhibition of cytochrome P-450 (CYP) were concerned during antituberculosis therapy. However, the information regarding human CYP inhibition by antituberculosis drugs is limited to isoniazid.
Yuki Nishimura, Norimitsu Kurata, Eriko Sakurai, Hajime Yasuhara   +3 more
doaj  

Possible GABAkine‐Mediated Sedative‐Like Antidepressant Effects of Phytol: Molecular Interventions Through In Vitro, In Vivo and In Silico Approaches

CNS Neuroscience &Therapeutics, Volume 31, Issue 3, March 2025.
Phytol (PHY) concentration‐dependently inhibited GABA activity and dose‐dependently reduced immobility time (IMT) in Swiss mice. It also modulated the GABA activity and IMT values of diazepam and flumazenil. It showed a slight sex‐dependent antidepressant effect on mice, possibly through the GABAA receptor interaction pathway.
Md. Torequl Islam, Jannatul Ferdous, Md. Sakib Al Hasan, Md. Shimul Bhuia, Irfan Aamer Ansari, Siddique Akber Ansari, Md. Amirul Islam, Md. Saifuzzaman   +7 more
wiley   +1 more source

Building Confidence in Physiologically Based Pharmacokinetic Modeling of CYP3A Induction Mediated by Rifampin: An Industry Perspective

Clinical Pharmacology &Therapeutics, Volume 117, Issue 2, Page 403-420, February 2025.
Physiologically‐based pharmacokinetic (PBPK) modeling offers a viable approach to predict induction drug–drug interactions (DDIs) with the potential to streamline or reduce clinical trial burden if predictions can be made with sufficient confidence. In the current work, the ability to predict the effect of rifampin, a well‐characterized strong CYP3A4 ...
Micaela B. Reddy, Tamara D. Cabalu, Loeckie de Zwart, Diane Ramsden, Martin E. Dowty, Kunal S. Taskar, Justine Badée, Jayaprakasam Bolleddula, Laurent Boulu, Qiang Fu, Masakatsu Kotsuma, Alix F. Leblanc, Gareth Lewis, Guiqing Liang, Neil Parrott, Venkatesh Pilla Reddy, Chandra Prakash, Kushal Shah, Kenichi Umehara, Dwaipayan Mukherjee, Jessica Rehmel, Niresh Hariparsad   +21 more
wiley   +1 more source

Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan [PDF]

, 2016
A list of SNPs that were not found in heterozygous or homozygous variants.
Aisha N. Iskakova, Akbota M. Aitkulova, Aliya A. Romanova, Elena V. Zholdybayeva, Erlan M. Ramanculov, Nurgul S. Sikhayeva   +5 more
core   +5 more sources

ASSOCIATION OF POLYMORPHISM IN BIOTRANSFORMATION SYSTEM GENES CYP1A1 AND GST WITH RISK OF RELAPSE IN CHILDHOOD ACUTE LEUKEMIA

Педиатрическая фармакология, 2007
Presence of polymorphism in genes coding biotransformation system may play an important role in formation of primary childhood acute leukemia, and affects the incidence and features of relapse.
O.A. Gra
doaj   +2 more sources

Assessment of Potential Drug–Drug Interactions for Novel Oral Melanocortin‐1 Receptor Agonist Dersimelagon

Pharmacology Research &Perspectives, Volume 13, Issue 1, February 2025.
ABSTRACT Dersimelagon is a novel investigational orally administered selective agonist of the melanocortin‐1 receptor. The drug–drug interaction (DDI) potential of dersimelagon was investigated in both nonclinical (in vitro) and clinical studies. The in vitro inhibition of CYP/UGT isoforms and efflux/uptake transporters by dersimelagon was assessed ...
Akihito Ogasawara, Ryosuke Ide, Shinsuke Inoue, Minoru Tsuda, Renli Teng   +4 more
wiley   +1 more source