Results 51 to 60 of about 29,283 (148)

CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids [PDF]

, 2017
Purpose When codeine and tramadol are used for pain management, it is imperative that nurses are able to assess for potential drug-gene and drug-drug-gene interactions that could adversely impact drug metabolism and ultimately pain relief.
Broome, Marion E., Burke Draucker, Claire, Carpenter, Janet S., Holmes, Ann M., Knisely, Mitchell R., Skaar, Todd C., Von Ah, Diane   +6 more
core   +1 more source

Inhibition of Tacrolimus Metabolism by Cannabidiol and Its Metabolites In Vitro

Clinical and Translational Science, Volume 18, Issue 2, February 2025.
ABSTRACT Drug interactions are major causes of interindividual variability in tacrolimus exposure and effect. Tacrolimus, a widely used drug in transplant patients, is metabolized by CYP3A4 and CYP3A5. Cannabidiol (CBD) use after transplant is common.
Gerald C. So, Jessica Bo Li Lu, Ying‐Hua Cheng, Debora L. Gisch, Sachiko Koyama, Ricardo Melo Ferreira, Travis R. Beamon, Zeruesenay Desta, Michael T. Eadon   +8 more
wiley   +1 more source

Physiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta‐9‐Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes

Clinical and Translational Science, Volume 18, Issue 1, January 2025.
ABSTRACT The two most extensively studied cannabinoids, cannabidiol (CBD) and delta‐9‐tetrahydrocannabinol (THC), are used for myriad conditions. THC is predominantly eliminated via the cytochromes P450 (CYPs), whereas CBD is eliminated through both CYPs and UDP‐glucuronosyltransferases (UGTs).
Lixuan Qian, Tao Zhang, Jean Dinh, Mary F. Paine, Zhu Zhou   +4 more
wiley   +1 more source

Importância prognóstica do alelo CYP2C19*2 após uma síndrome coronária aguda: dados de um centro nacional [PDF]

, 2012
BACKGROUND: Clopidogrel requires oxidation dependent on the cytochrome P450 enzyme 2C19 (CYP2C19) to form its active metabolite. The importance of loss-of-function alleles (particularly CYP2C19*2, 681G>A) in poor platelet response to clopidogrel is well ...
Ferreira, MJ, Freitas, M, Gonçalves, F, Lourenço, M, Marques, G, Monteiro, P, Monteiro, S, Pego, J, Providência, LA, Reboredo, A, Ribeiro, G, Tavares, C, Teixeira, R   +12 more
core  

Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study). [PDF]

, 2017
It is well known that the standard doses of a given drug may not have equivalent effects in all patients. To date, the management of depression remains mainly empirical and often poorly evaluated.
Bellivier, F., Besson, M., Calvas, F., Chevret, S., Courtet, P., Cracowski, J.L., Daali, Y., Davani, S., Desmeules, J., Desmidt, T., Doumy, O., Déglon, J., El-Hage, W., Galtier, F., Haesebaert, F., Haffen, E., Heron, K., Holtzmann, J., Le Corvoisier, P., Leboyer, M., Llorca, P.M., Lloret-Linares, C., Molière, F., Montange, D., Morange, S., Nieto, I., Richieri, R.M., Vignaud, P., Yon, L., Yrondi, A.   +29 more
core   +4 more sources

Schiff Bases From 4‐Aminoantipyrine: Investigation of Their In Silico, Antimicrobial, and Anticancer Effects and Their Use in Glucose Biosensor Design

Bioinorganic Chemistry and Applications, Volume 2025, Issue 1, 2025.
Five new Schiff bases from 4‐aminoantipyrine were synthesized, characterized, and evaluated for their antimicrobial and DNA cleavage activities, and drug similarity properties and cytotoxicity prediction using in silico analysis. All Schiff bases had good antibacterial and antifungal activities. All compounds showed self‐activating DNA cleavage ability
Aşkın Erbaş, Selinsu Dikim, Fatma Arslan, Onur Can Bodur, Seza Arslan, Fatma Özdemir, Nurşen Sarı, Claudio Pettinari   +7 more
wiley   +1 more source

Carriage of Cytochrome 2C19 Polymorphism Is Associated With Risk of High Post-Treatment Platelet Reactivity on High Maintenance-Dose Clopidogrel of 150 mg/day Results of the ACCEL-DOUBLE (Accelerated Platelet Inhibition by a Double Dose of Clopidogrel According to Gene Polymorphism) Study [PDF]

, 2010
ObjectivesThis study sought to determine the impact of gene polymorphisms on platelet reactivity (PR) after clopidogrel 150 mg/day in patients treated with percutaneous coronary intervention (PCI).BackgroundAlthough high maintenance-dose (MD) clopidogrel
Hwang, Jin-Yong, Hwang, Seok-Jae, Jeong, Young-Hoon, Kang, Min-Kyung, Kim, In-Suk, Koh, Jin-Sin, Kwak, Choong Hwan, Park, Yongwhi   +7 more
core   +1 more source

Influence of Rifampicin on the Pharmacokinetics of the Glucokinase Activator Globalagliatin: A Single‐Center, Open‐Label, Fixed‐Sequence Investigation in Healthy Chinese Volunteers

Journal of Clinical Pharmacy and Therapeutics, Volume 2025, Issue 1, 2025.
Objective: The orally bioavailable glucokinase activator, globalagliatin, is used to improve glucose homeostasis. Its metabolism is primarily dependent on cytochrome P450 (CYP) 3A4. Here, the influence of rifampicin, a potent inducer of CYP3A4 and CYP2C19 inducer, moderate inducer of CYP1A2, CYP2B6, CYP2C8, and CYP2C9, and inhibitor of P‐gp, on the ...
Yaqin Wang, Ya Liu, Maodi Xu, Minhui Wang, Xiaohu Wang, Weijin Liu, Cuilian Jiang, Lin Tan, Suoshuan Liu, Hua Sun, Haitang Xie, Seema Saroj   +11 more
wiley   +1 more source

Cytochrome P450 enzyme mediated herbal drug interactions (Part 1) [PDF]

, 2014
It is well recognized that herbal supplements or herbal medicines are now commonly used. As many patients taking prescription medications are concomitantly using herbal supplements, there is considerable risk for adverse herbal drug interactions.
Prachayasittikul, Virapong, Wanwimolruk, Sompon   +1 more
core  

Regulation of human CYP2C9 expression by electrophilic stress involves AP-1 activation and DNA looping [PDF]

, 2014
CYP2C9 and CYP2C19 are important human enzymes that metabolize therapeutic drugs, environmental chemicals and physiologically important endogenous compounds.
Goldstein, J. A., Makia, N. L., Monostory, K., Prough, R. A., Surapureddi, S.   +4 more
core   +1 more source