Results 11 to 20 of about 9,123 (152)

The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Cytochrome P450 3A4 (CYP3A4) is one of the most important members of the cytochrome P450 subfamily, which is involved in the catalytic process of many drug activation or deactivation. Meanwhile, it is also a risk factor for drug‐induced toxic reactions.
Wang F, Gu X, Hong H, Xia Q, Zhang Y, Song Y, Li B, Fan P.   +7 more
europepmc   +2 more sources

Population Pharmacokinetic and Exposure-Response Analyses of Ibrutinib Combined With Bendamustine and Rituximab in Patients With Mantle Cell Lymphoma. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Efficacy and safety of ibrutinib 560 mg once daily or placebo combined with bendamustine and rituximab (BR) were assessed in patients with mantle cell lymphoma in a randomized phase 3 study (SHINE). The analysis described explores the ibrutinib population pharmacokinetics (PK) and exposure‐response (E‐R) relationships of selected efficacy and ...
Gisleskog PO, Valenzuela B, Treijtel N, Deshpande S, Henninger T, Perez-Ruixo JJ.   +5 more
europepmc   +2 more sources

Deconvoluting Gut Versus Liver Cytochrome P450 3A4 Function: Drug Probes, Biomarkers, and Tissue Biopsy. [PDF]

J Clin Pharmacol
Abstract Cytochrome P450 3A4 (CYP3A4) is an important drug‐metabolizing enzyme, whose function is impacted by age, sex, body weight, pregnancy, and disease. It is also the site of major drug interactions involving inhibition and induction. Because CYP3A4 is expressed in the intestine and liver, investigators have sought to study its function in both ...
Rodrigues D.
europepmc   +2 more sources

Metabolic differences in colon mucosal cells [PDF]

, 1993
The colonic expression of cytochromes P450 from the CYP1A, CYP3A and CYP4B subfamilies has been characterized in rabbit and human tissues using RNA blotting, immunoblotting, immunohistochemistry and hybridization histochemistry. These studies demonstrate
Burgess, W. M., Gonzalez, F. J., McKinnon, R. A., McManus, M. E.   +3 more
core   +1 more source

Inhibitory Effect of Antituberculosis Drugs on Human Cytochrome P450-Mediated Activities

Journal of Pharmacological Sciences, 2004
The potential for drug-drug interactions mediated by the inhibition of cytochrome P-450 (CYP) were concerned during antituberculosis therapy. However, the information regarding human CYP inhibition by antituberculosis drugs is limited to isoniazid.
Yuki Nishimura, Norimitsu Kurata, Eriko Sakurai, Hajime Yasuhara   +3 more
doaj   +1 more source

Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in earlyand late-stage cholestasis [PDF]

, 2017
AIM: To ascertain whether cholestasis affects the expression of two CYP3A isoforms (CYP3A1 and CYP3A2) and of pregnane X receptor (PXR) and constitutive androstane receptor (CAR).
Albertoni, Laura, Baldo, Vincenzo, Baldovin, Tatjana, Carrara, Maria, DALLA POZZA, Arianna, De Martin, Sara, Floreani, Annarosa, Gabbia, Daniela, Lazzari, Roberta, Zigiotto, Giorgia   +9 more
core   +1 more source

Monitoring imatinib plasma concentrations in chronic myeloid leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2011
Imatinib has proved to be effective in the treatment of chronic myeloid leukemia, but plasma levels above 1,000 ng/mL must be achieved to optimize activity.
Darlize Hübner Martins, Sandrine Comparsi Wagner, Tamyris Vianna dos Santos, Lilian de Lima Feltraco Lizot, Marina Venzon Antunes, Marcelo Capra, Rafael Linden   +6 more
doaj   +1 more source

Predictors of Irinotecan Toxicity and Efficacy in Treatment of Metastatic Colorectal Cancer

Acta Medica, 2012
The colorectal cancer ranks high among the malignant tumours in incidence and mortality and irinotecan is standardly used in palliative treatment of metastatic disease in every therapeutic line.
Adam Paulík, Jiří Grim, Stanislav Filip   +2 more
doaj   +1 more source

Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.) [PDF]

, 2013
Chicory (Cichorium intybus) has been shown to induce enzymes of pharmacokinetic relevance (cytochrome P450; CYP). The aim of this study was to investigate the effects of selected secondary plant metabolites with a global extract of chicory root, on the ...
Ekstrand, Bo, Klausen, Christina Lindgaard, Rasmussen, Martin Krøyer   +2 more
core   +1 more source

The role of biotransformation processes in mediating interactions between psychotropic drugs and natural products [PDF]

, 2020
Many patients are not aware that natural products such as fruit juices or plant infusions can cause significant interactions with several drugs, some of which can be dangerous, especially when the medical treatment is for neurological or psychiatric ...
Bacinschi, Nicolae, Chianu, Marin, Mihalachi-Anghel, Maria, Podgurschi, Lilia, Pogonea, Ina, Socea, Bogdan, Ștefănescu, Emil   +6 more
core   +2 more sources