Results 51 to 60 of about 9,195 (133)

Functional Imaging of CYP3A4 at Multiple Dimensions Using an AI‐Driven High Performance Fluorogenic Substrate

Small, Volume 21, Issue 17, April 28, 2025.
This study showcases a novel artificial intelligence (AI)‐driven design strategy for constructing highly specific and orally‐active fluorogenic substrates for imaging CYP3A4 in complex biological systems, while NFa emerged as a practical and reliable tool for sensing and imaging of CYP3A4 activity thus facilitating CYP3A4‐associated fundamental ...
Feng Zhang, Lilin Song, Ruixuan Wang, Bei Zhao, Jian Huang, Luling Wu, Yufan Fan, Hong Lin, Zhengtao Jiang, Xiaodi Yang, Hairong Zeng, Xin Yang, Tony D. James, Guangbo Ge   +13 more
wiley   +1 more source

Effect of Piperine Pretreatment on Biochemical Profiles of Acetaminophen-Induced Hepatotoxicity in Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2012
BACKGROUND AND OBJECTIVE: Acetaminophen overdose is the most frequent cause of liver injuries. N-acetyl-p-benzoquinone imine (NAPQI) has been proposed as the toxic metabolite of acetaminophen induced by cytochrome P-450.
MT Kazemi, M Pour Nasrollah, MM Rezaei,, GH.A Jorsaraei, GH Maliji, S Kazemi, E Zabihi,, M Pouramir,, AA Moghadamnia   +8 more
doaj  

Translational high-dimensional drug Interaction discovery and validation using health record databases and pharmacokinetics models [PDF]

, 2017
Polypharmacy increases the risk of drug-drug interactions (DDI's). Combining epidemiological studies with pharmacokinetic modeling, we detected and evaluated high-dimensional DDI's among thirty frequent drugs.
Chiang, Chien-Wei, Li, Lang, Ning, Xia, Quinney, Sara K., Shen, Li, Wang, Lei, Wang, Xueying, Zhang, Pengyue, Zhang, Shijun   +8 more
core   +1 more source

A Drug–Drug Interaction Study of Mobocertinib and Midazolam, a Cytochrome P450 3A Substrate, in Patients With Advanced Non–Small Cell Lung Cancer

Clinical Pharmacology in Drug Development, Volume 14, Issue 3, Page 252-262, March 2025.
Abstract Mobocertinib is a kinase inhibitor designed to selectively target epidermal growth factor receptor (EGFR) exon 20 insertion (ex20ins) mutations in non‐small cell lung cancer. This drug–drug interaction study assessed the effect of multiple‐dose administration of mobocertinib on the pharmacokinetics (PK) of midazolam, a sensitive cytochrome ...
Michael J. Hanley, Steven Zhang, Nick Pavlakis, Ross A. Soo, Anthonie J. van der Wekken, Vinod Ganju, Adela Piña, Qi Dong, Neeraj Gupta   +8 more
wiley   +1 more source

Expression profiles of a drug metabolizing enzyme CYP3A62 mRNA in the intestine of rats [PDF]

, 2007
The purpose of this study was to examine the expression profiles of a drug metabolizing enzyme cytochrome P450 (CYP) 3A62 mRNA in the intestine and liver of normal male Wistar rats, and its regional differences in the intestinal tract. Nine-week-old male
Horibe, Sayo, Kishi, Hisato, Kitada, Noriaki, Ohnishi, Noriaki, Takara, Kohji, Yokoyama, Teruyoshi, Yoshikawa, Eri   +6 more
core  

Building Confidence in Physiologically Based Pharmacokinetic Modeling of CYP3A Induction Mediated by Rifampin: An Industry Perspective

Clinical Pharmacology &Therapeutics, Volume 117, Issue 2, Page 403-420, February 2025.
Physiologically‐based pharmacokinetic (PBPK) modeling offers a viable approach to predict induction drug–drug interactions (DDIs) with the potential to streamline or reduce clinical trial burden if predictions can be made with sufficient confidence. In the current work, the ability to predict the effect of rifampin, a well‐characterized strong CYP3A4 ...
Micaela B. Reddy, Tamara D. Cabalu, Loeckie de Zwart, Diane Ramsden, Martin E. Dowty, Kunal S. Taskar, Justine Badée, Jayaprakasam Bolleddula, Laurent Boulu, Qiang Fu, Masakatsu Kotsuma, Alix F. Leblanc, Gareth Lewis, Guiqing Liang, Neil Parrott, Venkatesh Pilla Reddy, Chandra Prakash, Kushal Shah, Kenichi Umehara, Dwaipayan Mukherjee, Jessica Rehmel, Niresh Hariparsad   +21 more
wiley   +1 more source

CYP3A-fenotype hos leddgiktpasienter i relasjon til inflammasjonsstatus og behandling med biologiske DMARDs [PDF]

, 2015
Bakgrunn: Enzymer tilhørende cytokrom P-450 3A (CYP3A)-subfamilien er de viktigste i metabolisme av legemidler. Systemisk inflammasjon er foreslått som en faktor til den store interindividuelle variabiliteten i CYP3A-fenotype, og 4β-hydroksykolesterol ...
Wollmann, Birgit Malene Tovik
core  

Population Genetic-Based Pharmacokinetic Modeling of Methadone and its Relationship with the QTc Interval in Opioid-Dependent Patients. [PDF]

, 2016
Methadone is a μ-opioid agonist widely used for the treatment of pain, and for detoxification or maintenance treatment in opioid addiction. It has been shown to exhibit large pharmacokinetic variability and concentration-QTc relationships.
Eap, C.B., Guidi, M.
core   +1 more source

Assessment of Potential Drug–Drug Interactions for Novel Oral Melanocortin‐1 Receptor Agonist Dersimelagon

Pharmacology Research &Perspectives, Volume 13, Issue 1, February 2025.
ABSTRACT Dersimelagon is a novel investigational orally administered selective agonist of the melanocortin‐1 receptor. The drug–drug interaction (DDI) potential of dersimelagon was investigated in both nonclinical (in vitro) and clinical studies. The in vitro inhibition of CYP/UGT isoforms and efflux/uptake transporters by dersimelagon was assessed ...
Akihito Ogasawara, Ryosuke Ide, Shinsuke Inoue, Minoru Tsuda, Renli Teng   +4 more
wiley   +1 more source

Echinacea purpurea Significantly Induces Cytochrome P450 3A Activity but Does Not Alter Lopinavir‐Ritonavir Exposure in Healthy Subjects [PDF]

, 2010
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90291/1/phco.30.8.797 ...
Behm Dillon DM, Blumenthal M, Budzinski JW, Cheryl Chairez, Christine Y Malati, James M Stevenson, Jennifer D Hunt, Joseph A Kovacs, Kligler B., Raul M Alfaro, Sarah M Robertson, Scott R Penzak, Shord SS, Yeh RF   +13 more
core   +1 more source