Results 141 to 150 of about 127,252 (263)
Chemistry – A European Journal, Accepted Article.The effect of a pendant neutral alcohol moiety in the N‐alkylated cyclam (1,4,8,11‐tetraazacyclotetradecane) ligand backbone is examined for the non‐heme mononuclear oxoiron(IV) unit in [FeIV(Osyn)(TMC‐HOR)(NCCH3)]2+ (1‐syn) (TMC‐HOR = 2‐(4,8,11‐trimethyl‐1,4,8,11‐tetraazacyclotetradecan1‐yl)ethan‐1‐ol).
Dibya Jyoti Barman +6 more
wiley +1 more source
Hepatology, EarlyView., 2022 Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim +12 more
wiley +1 more source
Fragrances of Cage Bicyclic Benzene Bioisosteres
Chemistry – A European Journal, EarlyView.Does it pass the “sniff” test! Cubane, bicyclo[1.1.1]pentane and bicyclo[2.2.2]octane derivatives of known aromatic fragrances were prepared and evaluated using a sensory evaluation to determine if similar scent characteristics were present between the parent and cage bicyclic bioisosteres. Abstract Cubane, bicyclo[1.1.1]pentane (BCP) and bicyclo[2.2.2]
Grace R. M. O'Donohue +6 more
wiley +1 more source
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Binuclear lanthanide complexes as magnetic resonance and optical imaging probes for redox sensing
Chemistry – A European Journal, Accepted Article.We report a family of lanthanide(III) complexes that act as redox probes via both magnetic resonance and luminescence outputs. The ligands are functionalized with nitro, azobenzene and azide groups which are reduced to a common aniline product, and each responds to both chemical and biocatalytic reductive conditions at different cathodic onset ...
Charlie H. Simms +12 more
wiley +1 more source
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes
Chemistry – A European Journal, Accepted Article.Advanced clinical trials investigate the Psilocybe magic mushroom natural product psilocybin as a treatment against major depressive disorder. Currently, synthetic material is used to meet the demand for legitimate pharmaceutical purposes. Here, we report an in vitro approach to biocatalytically produce psilocybin on a solid‐phase matrix charged with ...
Tim Schäfer +7 more
wiley +1 more source
Integrated Environmental Assessment and Management, Volume 19, Issue 1, Page 24-31, January 2023., 2023 Abstract Effects‐based methods (EBMs) are considered part of a more integrative strategy for regulating substances of concern under the European Union Water Framework Directive. In general, EBMs have been demonstrated as useful indicators of effects on biota, although links to population and community‐level effects are sometimes uncertain.
Kevin V. Brix +5 more
wiley +1 more source
Journal of Applied Toxicology, Volume 43, Issue 1, Page 22-31, January 2023., 2023 Abstract Titanium dioxide (TiO2) is used extensively as a white pigment in the food industry, personal care, and a variety of products of everyday use. Although TiO2 has been categorized as a bioinert material, recent evidence has demonstrated different toxicity profiles of TiO2 nanoparticles (NPs) and a potential health risk to humans.
Vida Mohammadparast, Beth L. Mallard
wiley +1 more source