F1000Research, 2017 Cytochrome P450, a family of monooxygenase enzymes, is organized as a catalytic metabolon, which requires enzymatic partners as well as environmental factors that tune its complex dynamic.
Carlo Barnaba +3 more
doaj +2 more sources
Cytochrome P450 Enzymes and Drug Metabolism in Humans
International Journal of Molecular Sciences, 2021 Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In humans, almost 80% of oxidative metabolism and approximately 50% of the overall elimination
Mingzhe Zhao +10 more
semanticscholar +1 more source
Molecular Characterization and Functional Analysis of Cytochrome b5 Reductase (CBR) Encoding Genes from the Carotenogenic Yeast Xanthophyllomyces dendrorhous. [PDF]
PLoS ONE, 2015 The eukaryotic microsomal cytochrome P450 systems consist of a cytochrome P450 enzyme (P450) and a cytochrome P450 redox partner, which generally is a cytochrome P450 reductase (CPR) that supplies electrons from NADPH.
María Soledad Gutiérrez +5 more
doaj +1 more source
Role of Cytochrome P450 Enzymes in Plant Stress Response
Antioxidants, 2020 Cytochrome P450s (CYPs) are the largest enzyme family involved in NADPH- and/or O2-dependent hydroxylation reactions across all the domains of life. In plants and animals, CYPs play a central role in the detoxification of xenobiotics. In addition to this
Balaji Aravindhan Pandian +4 more
semanticscholar +1 more source
Abstract P-11: Microscale Thermophoresis of Mycobacterial Cytochrome P450 with Azole Drugs [PDF]
International Journal of Biomedicine, 2021 Background: Cytochrome P450 family members are found in most organisms where they are involved in the metabolism and synthesis of steroids, bile acids, unsaturated fatty acids, phenolic metabolites as well as exogenic chemicals.
Ivan Kapranov +7 more
doaj +1 more source
Measurement of cytochrome P450 and NADPH–cytochrome P450 reductase [PDF]
Nature Protocols, 2009 Cytochrome P450 (P450) enzymes are important in the metabolism of steroids, vitamins, carcinogens, drugs and other compounds. Two of the commonly used assays in this field are the measurements of total P450 and NADPH-P450 reductase in biological preparations. A detailed protocol is presented for the measurement of P450 by its spectral properties, along
F. Peter Guengerich +3 more
openaire +3 more sources
An Exploration of the Sub-Register of Chemical Engineering Research Papers Published in English
Publications, 2018 The increased pressures for high-volume, high-impact publications in English language and the high rejection rates of submitted manuscripts for publications present an often unsurpassable obstacle for (early career) researchers.
Myrto-Panagiota Zacharof +1 more
doaj +1 more source
Cytochrome P450 metabolism mediates low‐temperature resistance in pinewood nematode
FEBS Open Bio, 2020 Pinewood nematode (PWN; Bursaphelenchus xylophilus) is a devastating invasive species that is expanding into colder regions. Here, we investigated the molecular mechanisms underlying low‐temperature resistance of PWN.
Bowen Wang +6 more
doaj +1 more source
The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer [PDF]
, 2014 Peer reviewedPublisher ...
Alnabulsi, Ayham +5 more
core +7 more sources
Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame. [PDF]
, 2016 The endoplasmic reticulum (ER)-anchored hepatic cytochromes P450 (P450s) are enzymes that metabolize endo- and xenobiotics i.e. drugs, carcinogens, toxins, natural and chemical products.
Correia, Maria Almira +4 more
core +1 more source