Abstract P-11: Microscale Thermophoresis of Mycobacterial Cytochrome P450 with Azole Drugs [PDF]
International Journal of Biomedicine, 2021 Background: Cytochrome P450 family members are found in most organisms where they are involved in the metabolism and synthesis of steroids, bile acids, unsaturated fatty acids, phenolic metabolites as well as exogenic chemicals.
Ivan Kapranov +7 more
doaj +1 more source
Pharmacogenetics and Genomics, 2009 The cytochrome P450 2D6 (CYP2D6) is an enzyme of great historical importance for pharmacogenetics and is now thought to be involved in the metabolism of up to 25% of the drugs that are in common use in the clinic [1]. Several years before the gene was cloned, researchers observed that Caucasian population responded in a bimodal pattern to certain drugs
Ryan P, Owen +3 more
openaire +2 more sources
An Exploration of the Sub-Register of Chemical Engineering Research Papers Published in English
Publications, 2018 The increased pressures for high-volume, high-impact publications in English language and the high rejection rates of submitted manuscripts for publications present an often unsurpassable obstacle for (early career) researchers.
Myrto-Panagiota Zacharof +1 more
doaj +1 more source
Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency [PDF]
, 2010 Objective: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency(ORD) present with disordered sex development and glucocorticoid deficiency.
Arlt +25 more
core +2 more sources
Resistance risk assessment of the novel complex II inhibitor pyflubumide in the polyphagous pest Tetranychus urticae [PDF]
, 2020 Pyflubumide is a novel selective carboxanilide acaricide that inhibits mitochondrial complex II of spider mite species such as Tetranychus urticae. We explored the baseline toxicity and potential cross-resistance risk of pyflubumide in a reference panel ...
Fotoukkiaii, Seyedeh Masoumeh +3 more
core +1 more source
Cytochrome P450 metabolism mediates low‐temperature resistance in pinewood nematode
FEBS Open Bio, 2020 Pinewood nematode (PWN; Bursaphelenchus xylophilus) is a devastating invasive species that is expanding into colder regions. Here, we investigated the molecular mechanisms underlying low‐temperature resistance of PWN.
Bowen Wang +6 more
doaj +1 more source
Cloning and Expression of Multiple Cytochrome P450 Genes: Induction by Fipronil in Workers of the Red Imported Fire Ant (Solenopsis invicta Buren). [PDF]
PLoS ONE, 2016 Both exogenous and endogenous compounds can induce the expression of cytochrome P450 genes. The insect cytochrome P450 genes related to insecticide resistance are likely to be expressed as the "first line of defense" when challenged with insecticides. In
Baizhong Zhang +4 more
doaj +1 more source
Measurement of cytochrome P450 and NADPH–cytochrome P450 reductase [PDF]
Nature Protocols, 2009 Cytochrome P450 (P450) enzymes are important in the metabolism of steroids, vitamins, carcinogens, drugs and other compounds. Two of the commonly used assays in this field are the measurements of total P450 and NADPH-P450 reductase in biological preparations. A detailed protocol is presented for the measurement of P450 by its spectral properties, along
F Peter, Guengerich +3 more
openaire +2 more sources
Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution Genome evolution and evolutionary systems biology [PDF]
, 2014 © 2014 Janha et al.; licensee BioMed Central Ltd.Background: Cytochrome P450 CYP2C19 metabolizes a wide range of pharmacologically active substances and a relatively small number of naturally occurring environmental toxins.
Janha, RE +5 more
core +3 more sources
Methods for determining Cytochrome P450 reductase in biological fluids of animals [PDF]
BIO Web of ConferencesThe study provides a literature review of modern methods for determining Cytochrome P450 reductase. The importance of the enzyme in the body is established.
Ponamarev Vladimir
doaj +1 more source