Actinorhodin Biosynthesis Terminates with an Unprecedented Biaryl Coupling Reaction
Angewandte Chemie, Volume 135, Issue 5, January 26, 2023., 2023 The last dimerization step of actinorhodin (ACT) biosynthesis was established through biochemical studies. ActVA‐ORF4 is a unique NAD(P)H‐dependent enzyme that catalyzes the biaryl‐coupling reaction using 8‐hydroxydihydrokalafungin (DHK‐OH) as the sole substrate. ActVA‐ORF3 is a quinone‐forming enzyme that forms DHK‐OH and ACT.
Makoto Hashimoto +6 more
wiley +2 more sources
Angewandte Chemie, Volume 135, Issue 5, January 26, 2023., 2023 A lyophilized preparation of an unspecific peroxygenase variant from Agrocybe aegerita (rAaeUPO‐PaDa‐I‐H) is a highly effective catalyst for the oxygenation of a diverse range of N‐heterocyclic compounds. Scalable, high yielding and enantioselective biocatalytic oxygenations have been developed, including 27 preparative examples (ca.
Balázs Pogrányi +5 more
wiley +2 more sources
Accelerating Quantum Computations of Chemistry Through Regularized Compressed Double Factorization [PDF]
Quantum 8, 1371 (2024), 2022 We propose the regularized compressed double factorization (RC-DF) method to classically compute compressed representations of molecular Hamiltonians that enable efficient simulation with noisy intermediate scale (NISQ) and error corrected quantum algorithms.
arxiv +1 more source
Molecular Characterization and Functional Analysis of Cytochrome b5 Reductase (CBR) Encoding Genes from the Carotenogenic Yeast Xanthophyllomyces dendrorhous. [PDF]
PLoS ONE, 2015 The eukaryotic microsomal cytochrome P450 systems consist of a cytochrome P450 enzyme (P450) and a cytochrome P450 redox partner, which generally is a cytochrome P450 reductase (CPR) that supplies electrons from NADPH.
María Soledad Gutiérrez +5 more
doaj +1 more source
Abstract P-11: Microscale Thermophoresis of Mycobacterial Cytochrome P450 with Azole Drugs [PDF]
International Journal of Biomedicine, 2021 Background: Cytochrome P450 family members are found in most organisms where they are involved in the metabolism and synthesis of steroids, bile acids, unsaturated fatty acids, phenolic metabolites as well as exogenic chemicals.
Ivan Kapranov +7 more
doaj +1 more source
Measurement of cytochrome P450 and NADPH–cytochrome P450 reductase [PDF]
Nature Protocols, 2009 Cytochrome P450 (P450) enzymes are important in the metabolism of steroids, vitamins, carcinogens, drugs and other compounds. Two of the commonly used assays in this field are the measurements of total P450 and NADPH-P450 reductase in biological preparations. A detailed protocol is presented for the measurement of P450 by its spectral properties, along
F. Peter Guengerich +3 more
openaire +3 more sources
Reliably assessing the electronic structure of cytochrome P450 on today's classical computers and tomorrow's quantum computers [PDF]
, 2022 An accurate assessment of how quantum computers can be used for chemical simulation, especially their potential computational advantages, provides important context on how to deploy these future devices. In order to perform this assessment reliably, quantum resource estimates must be coupled with classical simulations attempting to answer relevant ...
arxiv +1 more source
An Exploration of the Sub-Register of Chemical Engineering Research Papers Published in English
Publications, 2018 The increased pressures for high-volume, high-impact publications in English language and the high rejection rates of submitted manuscripts for publications present an often unsurpassable obstacle for (early career) researchers.
Myrto-Panagiota Zacharof +1 more
doaj +1 more source
Cytochrome P450 metabolism mediates low‐temperature resistance in pinewood nematode
FEBS Open Bio, 2020 Pinewood nematode (PWN; Bursaphelenchus xylophilus) is a devastating invasive species that is expanding into colder regions. Here, we investigated the molecular mechanisms underlying low‐temperature resistance of PWN.
Bowen Wang +6 more
doaj +1 more source
Cloning and Expression of Multiple Cytochrome P450 Genes: Induction by Fipronil in Workers of the Red Imported Fire Ant (Solenopsis invicta Buren). [PDF]
PLoS ONE, 2016 Both exogenous and endogenous compounds can induce the expression of cytochrome P450 genes. The insect cytochrome P450 genes related to insecticide resistance are likely to be expressed as the "first line of defense" when challenged with insecticides. In
Baizhong Zhang +4 more
doaj +1 more source