Results 21 to 30 of about 161,046 (260)

Cytochromes P450 in Nanodiscs [PDF]

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2011
Nanodiscs have proven to be a versatile tool for the study all types of membrane proteins, including receptors, transporters, enzymes and viral antigens. The self-assembled Nanodisc system provides a robust and common means for rendering these targets soluble in aqueous media while providing a native like bilayer environment that maintains functional ...
Ilia G, Denisov, Stephen G, Sligar
openaire   +2 more sources

Cytochrome P450 metabolism mediates low‐temperature resistance in pinewood nematode

FEBS Open Bio, 2020
Pinewood nematode (PWN; Bursaphelenchus xylophilus) is a devastating invasive species that is expanding into colder regions. Here, we investigated the molecular mechanisms underlying low‐temperature resistance of PWN.
Bowen Wang, Xin Hao, Jiayao Xu, Buyong Wang, Wei Ma, Xuefeng Liu, Ling Ma   +6 more
doaj   +1 more source

An Exploration of the Sub-Register of Chemical Engineering Research Papers Published in English

Publications, 2018
The increased pressures for high-volume, high-impact publications in English language and the high rejection rates of submitted manuscripts for publications present an often unsurpassable obstacle for (early career) researchers.
Myrto-Panagiota Zacharof, Anna Charalambidou   +1 more
doaj   +1 more source

Methods for determining Cytochrome P450 reductase in biological fluids of animals [PDF]

BIO Web of Conferences
The study provides a literature review of modern methods for determining Cytochrome P450 reductase. The importance of the enzyme in the body is established.
Ponamarev Vladimir
doaj   +1 more source

Cloning and Expression of Multiple Cytochrome P450 Genes: Induction by Fipronil in Workers of the Red Imported Fire Ant (Solenopsis invicta Buren). [PDF]

PLoS ONE, 2016
Both exogenous and endogenous compounds can induce the expression of cytochrome P450 genes. The insect cytochrome P450 genes related to insecticide resistance are likely to be expressed as the "first line of defense" when challenged with insecticides. In
Baizhong Zhang, Lei Zhang, Rukun Cui, Xinnian Zeng, Xiwu Gao   +4 more
doaj   +1 more source

Cytochrome P450 monooxygenases

Current Opinion in Chemical Biology, 1998
The field of P450 research is progressing rapidly. The active sites of structurally characterized bacterial P450 enzymes have been rationally re-engineered to alter both substrate specificity and selectivity of substrate oxidation. Many human P450 enzymes have been functionally expressed and new methods of substrate turnover described.
HALKIER BARBARA ANN, BAK SOEREN, KAHN RACHEL ALICE, MOELLER BIRGER LINDBERG   +3 more
openaire   +6 more sources

Cytochrome P450 2D6 [PDF]

Pharmacogenetics and Genomics, 2009
The cytochrome P450 2D6 (CYP2D6) is an enzyme of great historical importance for pharmacogenetics and is now thought to be involved in the metabolism of up to 25% of the drugs that are in common use in the clinic [1]. Several years before the gene was cloned, researchers observed that Caucasian population responded in a bimodal pattern to certain drugs
Ryan P, Owen, Katrin, Sangkuhl, Teri E, Klein, Russ B, Altman   +3 more
openaire   +2 more sources

CYTOCHROME P450 ENZYMES AND PSYCHOTROPIC DRUGS

Psychiatry and Clinical Psychopharmacology, 2021
The discovery of the importance of cytochrome P450 enzymes in drug metabolism has been very recently.The information about the diversity,specificity and interindividual variation o f cytochrome P450 enzymes is increasing rapidly.
Nesrin Karamustafalıoğlu, H.Erdem Karaman, Nihat Alpay   +2 more
doaj  

Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease. [PDF]

PLoS ONE, 2016
Niemann-Pick type C (NPC) disease is a neurodegenerative lysosomal storage disease caused by mutations in either the NPC1 or NPC2 gene. NPC is characterised by storage of multiple lipids in the late endosomal/lysosomal compartment, resulting in cellular ...
Elena-Raluca Nicoli, Nada Al Eisa, Celine V M Cluzeau, Christopher A Wassif, James Gray, Kathryn R Burkert, David A Smith, Lauren Morris, Stephanie M Cologna, Cody J Peer, Tristan M Sissung, Constantin-Daniel Uscatu, William D Figg, William J Pavan, Charles H Vite, Forbes D Porter, Frances M Platt   +16 more
doaj   +1 more source

The role of nicotinamide-β-adenine dinucleotide phosphate-H-cytochrome P450 oxidoreductase in the activation of cytochromes [PDF]

BIO Web of Conferences
The aim of this theoretical study is to investigate the mechanisms of action of these enzymes in the context of metabolism in highly productive animals.
Popova Olga, Bylinskaya Daria, Nikitina Anastasia, Ukrainskaya Olga   +3 more
doaj   +1 more source