Results 41 to 50 of about 297,833 (301)
The interplay between tubulins and P450 cytochromes during Plasmodium berghei invasion of Anopheles gambiae midgut. [PDF]
PLoS ONE, 2011 BACKGROUND: Plasmodium infection increases the oxidative stress inside the mosquito, leading to a significant alteration on transcription of Anopheles gambiae detoxification genes.
Rute C Félix, Henrique Silveira
doaj +1 more source
Cytochromes P450 : from model compounds towards artificial hemoproteins [PDF]
, 2007 Cytochromes P450 are heme-thiolate proteins abundant in nature. These monooxygenases catalyse a variety of reactions including alkene epoxixation, N-, O-, and S-dealkylation, C-C bond cleavage and hydrocarbon hydroxylation.
Büttiker, Dominik
core +1 more source
Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni +19 more
wiley +1 more source
Annals of Clinical Microbiology and Antimicrobials, 2008 Introduction People infected with human immunodeficiency virus are frequently treated with medications that can induce or inhibit cytochrome P450 enzymes.
Horne Anne M +3 more
doaj +1 more source
Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain [PDF]
, 2009 In low nanomolar concentrations, NO (nitric oxide) functions as a transmitter in brain and other tissues, whereas near-micromolar NO concentrations are associated with toxicity and cell death.
Keynes, R.G. +5 more
core
Molecular simulations on proteins of biomedical interest : A. Ligand-protein hydration B. Cytochrome P450 2D6 and 2C9 C. Myelin associated glycoprotein (MAG) [PDF]
, 2011 TOPIC 1: Water molecules mediating polar interactions in ligand–protein complexes contribute to both binding affinity and specificity. To account for such water molecules in computer-aided drug discovery, we performed an extensive search in the Cambridge
Rossato, Gianluca
core +1 more source
Cytochrome P450-Mediated Cyclization in Eunicellane-Derived Diterpenoid Biosynthesis [PDF]
, 2023 Terpene cyclization, one of the most complex chemical reactions in nature, is generally catalyzed by two classes of terpene cyclases (TCs). Cytochrome P450s that act as unexpected TC-like enzymes are known but are very rare.
Liao-Bin, Dong +9 more
core +2 more sources
Arthritis Care &Research, EarlyView.Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel +6 more
wiley +1 more source
Ecotoxicology and Environmental SafetyGeosmin is an environmental pollutant that causes off-flavor in water and aquatic products. The high occurrence of geosmin contamination in aquatic systems and aquaculture raises public awareness, however, few studies have investigated the response ...
Jun-ming Zhang +9 more
doaj +1 more source
Journal of Integrative Agriculture, 2016 The red imported fire ant (Solenopsis invicta) is a global major invasive pest, and has caused significant economic, social and environmental impacts since its invasion to mainland of China in 2004.
Bai-zhong ZHANG +5 more
doaj +1 more source