Results 51 to 60 of about 7,052 (211)

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

A Lipid‐Conjugation Strategy for Intracellular Reactive Oxygen Species Control in Hepatic Cells

Angewandte Chemie, EarlyView.
A lipid conjugation strategy anchors a manganese Salen complex within phospholipid membranes, yielding stable, catalytically active liposomes. These lipid–metal assemblies efficiently degrade reactive oxygen species (ROS) and enable intracellular redox control in steatotic HepaRG cells, offering a precise route to biomimetic antioxidant design ...
Olav Vestrheim, Huichao Zhao, Anders Bodholt Nielsen, Nino Wili, Niels Chr. Nielsen, Joseph A. Lyons, Rajeshwar Prosad Mookerjee, Brigitte Städler   +7 more
wiley   +2 more sources

In-silico study of some natural compounds used as antifungal agents against Candida albicans

European Journal of Biological Research, 2020
Fungal diseases are very common these days, so there is a high need to design and develop new antifungal drugs that can counter these diseases. Candida albicans is one of the opportunistic pathogenic yeasts that can cause serious diseases such as ...
Ankita Srivastava, Neelabh -
doaj  

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Single‐Atom Iron‐Catalyzed Oxidative Esterification: From Methylarenes to the Upcycling of Polystyrene and Lignin‐Derived Feedstocks

Angewandte Chemie, EarlyView.
Heterogeneous iron‐catalyzed environmentally benign and sustainable CH‐oxidative esterification methodology has been developed for the synthesis of esters. This challenging reaction has been achieved by the rational design of specific single atom iron‐based catalyst with Fe‐N4 active centers, which empowered the oxidative esterification of methyl and ...
Zhuang Ma, Binyu Zhang, Hui Yang, Yue Hu, Junzheng Yu, Yanbin Cui, Jun Zhao, Matthias Beller, Rajenahally V. Jagadeesh   +8 more
wiley   +2 more sources

Molecular Docking of Brassicasterol Inhibition from Green Mustard Plant (Brassica Chinensis Var. Parachinensis) with Cytochrome P450 in Treating Chagas Disease

Sains Natural
The aim of this study was to evaluate the potential of brassicasterol found in mustard greens as a cytochrome P450 inhibitor using a computational approach.
Okta Suryani, Ade Irma Fahira
doaj   +1 more source

A simple and rapid method to measure cholesterol binding to P450s and other proteins

Journal of Lipid Research, 2005
Cholesterol plays an important role in cellular function and membrane compartmentalization and is involved in the interaction with more than a dozen of different proteins. Using three cholesterol-metabolizing cytochrome P450s (P450s 7A1, 46A1, and 11A1),
Natalia Mast, Irina A. Pikuleva
doaj   +1 more source

Cytochrome P450-Activated Prodrugs [PDF]

Future Medicinal Chemistry, 2013
A prodrug is a compound that has negligible, or lower, activity against a specified pharmacological target than one of its major metabolites. Prodrugs can be used to improve drug delivery or pharmacokinetics, to decrease toxicity, or to target the drug to specific cells or tissues.
openaire   +4 more sources

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source

Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration

Angewandte Chemie, EarlyView.
The nitrosuccinate lyase CreD catalyzes C–NO2 bond formation using nitrite in water and shows synthetic practicality with high turnover numbers up to 102,000. A combination of protein engineering and computational methods helped to reveal the mechanistic principles that underpin this unique enzymatic activity.
Matteo Aleotti, Hannah Dreisbach, Rémi Corlay, Clara Weber, Tamara Reiter, Wael Elaily, Bastian Daniel, Klaus Zangger, Pedro A. Sánchez‐Murcia, Mélanie Hall   +9 more
wiley   +2 more sources