Results 31 to 40 of about 297,833 (301)
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mBio, 2020 Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown what mechanisms
Jeffrey M. Rybak +12 more
doaj +1 more source
Cytochrome P450 2S1 is Reduced by NADPH-Cytochrome P450 Reductase [PDF]
Drug Metabolism and Disposition, 2011 Cytochrome P450 (P450) 2S1 is one of the orphan P450s without a clear physiological function. Controversy has arisen as to whether it can interact with NADPH-P450 reductase and accept electrons. The reduction of 1,4-bis{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione (AQ4N) by P450 2S1 was confirmed, and the NADPH consumption ...
Yi, Xiao +2 more
openaire +2 more sources
Romanian Journal of Laboratory Medicine, 2023 Background: Procollagen type I amino-terminal propeptide (PINP) is often present during osteoblast development and could be a biomarker of early bone development. Osteoprotegerin (OPG) may protect tumor cells from apoptosis.
Yousif Pshtiwan A. +1 more
doaj +1 more source
Scientific Reports, 2018 The COS-7 (CV-1 in Origin with SV40 genes) cells are known as non-steroidogenic cells because they are derived from kidney cells and the kidney is defined as a non-steroidogenic organ.
Mitsuki Nozaki +9 more
doaj +1 more source
Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin
Molecules, 2010 We have examined the influence of diluted pure celery and parsley leaf and root juices and their combinations with doxorubicin on the antioxidant status [as measured by the content of reduced glutathione (GSH) and ferric reducing antioxidant power (FRAP)]
Svetlana Trivic +4 more
doaj +1 more source
Molecules, 2023 Osteoarthritis is one of the leading conditions that promote the consumption of these dietary supplements. Chondroitin sulfate, glucosamine, and methylsulfonylmethane are among the prominent alternative treatments for osteoarthritis. In this study, these
Su Min Kim +5 more
doaj +1 more source
Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11 [PDF]
, 2009 In this study, we investigated the regioselective binding mode of steroid molecules and structure requirements for steroid molecules for 16[alpha]-hydroxylation by Cytochrome P450-2C11.
Morio Yamada +3 more
core
Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution [PDF]
, 2014 © 2014 Janha et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Worwui, A +17 more
core +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Cytochrome P450: Electron transfer and sensors
, 2022 S.1-11Electrochemical methods allow to characterize the reaction mechanism of the cytochrome P450 (CYP) enzymes by observing the electron transfer in real time.
Wollenberger, U. +2 more
core +1 more source