Results 211 to 220 of about 127,252 (263)

Physiologically Based Pharmacokinetic Modeling and Simulation to Support a Change in the FDA‐Labeled Dosing Frequency of RHB‐105 Low‐Dose Rifabutin Triple Therapy for Helicobacter pylori Eradication

The Journal of Clinical Pharmacology, EarlyView.
Abstract Patient adherence is vital for Helicobacter pylori eradication. Simplifying therapy dosing schedules may promote patient adherence, enhance treatment success rates, and help mitigate the development of antibiotic resistance. We aimed to assess plasma and intragastric rifabutin, amoxicillin, and omeprazole concentrations comparing two dosing ...
Nimish Vakil, Colin W. Howden, Shailja C. Shah, Kuan‐Fu Chen, Elliot Offman, June S. Almenoff, Kely L. Sheldon   +6 more
wiley   +1 more source

A Computational Pipeline Observes the Flexibility and Dynamics of Plant Cytochrome P450 Binding Sites. [PDF]

Int J Mol Sci
Kuvek T, Marcher C, Berteotti A, Lopez Carrillo V, Schleifer KJ, Oostenbrink C.   +5 more
europepmc   +1 more source

Evaluation of Cannabis Per Se Laws: A Semi‐Mechanistic Pharmacometrics Model for Quantitative Characterization of THC and Metabolites in Oral Users

The Journal of Clinical Pharmacology, EarlyView.
Abstract Recreational cannabis use has increased notably in the United States in the past decade, with a recent surge in oral consumption. This trend has raised concerns about driving under the influence. Current cannabis‐impaired driving laws lack standardization, with some states implementing blood Δ9‐tetrahydrocannabinol (THC) per se limits (1, 2 ...
Peizhi Li, Guohua An
wiley   +1 more source

Overexpression of multiple cytochrome P450 genes with and without knockdown resistance mutations confers high resistance to deltamethrin in Culex quinquefasciatus. [PDF]

Infect Dis Poverty
Chamnanya S, Kiddela B, Saingamsook J, Nachaiwieng W, Lumjuan N, Somboon P, Yanola J.   +6 more
europepmc   +1 more source

Clinical Assessment of the Drug–Drug Interaction Potential of Omaveloxolone in Healthy Adult Participants

The Journal of Clinical Pharmacology, EarlyView.
Abstract Omaveloxolone is approved in the United States and the European Union for the treatment of patients with Friedreich ataxia aged ≥16 years. It is mainly metabolized by cytochrome P450 (CYP) 3A4 in vitro. Two drug–drug interaction studies (NCT04008186 and NCT05909644) were performed to evaluate (1) the effect of drug‐metabolizing enzymes (DMEs ...
Hamim Zahir, Masako Murai, Lucy Wu, Michelle Valentine, Scott Hynes   +4 more
wiley   +1 more source

Examining the Impact of Diet‐and‐Exercise‐Induced Weight Loss on Drug Metabolism and Gastric Emptying in Patients with Obesity

The Journal of Clinical Pharmacology, EarlyView.
Abstract Obesity significantly influences drug pharmacokinetics (PK), which challenges optimal dosing. This study examines the effects of diet‐and‐exercise‐induced weight loss on key drug‐metabolizing enzymes and gastric emptying in patients with obesity, who frequently require medications for comorbidities.
Shuhan Liu, Lu Wang, Nicole Miller, Andrea Waltje, Mohamed Abdelnabi, Hao‐Jie Zhu, Duxin Sun, Amy E. Rothberg, Manjunath P. Pai   +8 more
wiley   +1 more source

Cytochrome P450 VvCYP76F14 dominates the production of wine bouquet precursors in wine grapes. [PDF]

Front Plant Sci
Xia G, Shi M, Xu W, Dark A, Song Z.
europepmc   +1 more source

Population Pharmacokinetics of Fruquintinib, a Selective Oral Inhibitor of VEGFR ‐1, ‐2, and ‐3, in Patients with Refractory Metastatic Colorectal Cancer

The Journal of Clinical Pharmacology, EarlyView.
Abstract Fruquintinib is a selective, oral tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors 1, 2, and 3, which is approved for patients with previously treated metastatic colorectal cancer regardless of biomarker status. This population pharmacokinetic (PK) analysis characterized sources of interpatient variability on
Xiaofei Zhou, Xiaoyan Yang, Boris Grinshpun, Adekemi Taylor, Laura Strong, Arvind Dasari, Andrea Wang‐Gillam, Jin Li, Rui‐Hua Xu, Neeraj Gupta, Caly Chien   +10 more
wiley   +1 more source

The Effect of Metformin and Hydrochlorothiazide on Cytochrome P450 3A4 Metabolism of Ivermectin: Insights from In Silico Experimentation. [PDF]

Int J Mol Sci
Mtambo TR, Machaba KE, Chellan N, Ramharack P, Muller CJF, Mhlongo NN, Hlengwa N.   +6 more
europepmc   +1 more source