Results 221 to 230 of about 127,252 (263)

The Impact of Augmented Renal Clearance on the Pharmacokinetics of Levetiracetam in Critically Ill Patients: A Literature Review

The Journal of Clinical Pharmacology, EarlyView.
Abstract Levetiracetam is an antiseizure medication (ASM) that has several advantages over other ASMs, such as dose‐proportional pharmacokinetics, high bioavailability, and minimal drug interactions. The drug is primarily eliminated through the kidneys. Therefore, dose adjustments are necessary in patients with renal impairment or patients experiencing
Maged Kharouba, Asma Aboelezz, Janice Y. Kung, Sherif Hanafy Mahmoud   +3 more
wiley   +1 more source

Evaluation of the Effect of Risankizumab on the Pharmacokinetics of Cytochrome P450 Substrates in Patients with Moderately to Severely Active Ulcerative Colitis or Crohn's Disease. [PDF]

Clin Pharmacokinet
D'Cunha R, Azam T, Kalabic J, Anschutz T, Lahat A, Pang Y.   +5 more
europepmc   +1 more source

In Vitro and Clinical Evaluations of UGT1A1‐, P‐gp‐, OATP1B1‐, and BCRP‐Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

The Journal of Clinical Pharmacology, EarlyView.
Abstract Belumosudil is an oral selective rho‐associated coiled‐coil containing protein kinase 2 inhibitor, approved as a treatment for chronic graft‐versus‐host disease. Prior clinical studies demonstrated that coadministration with strong CYP3A4 inducers or proton pump inhibitors requires dose modification of belumosudil.
Olivier Schueller, Lauren Lohmer, Felix Beck, Jeegar Patel, Jasminder Sahi   +4 more
wiley   +1 more source

Erratum: Triterpenoids from Ganoderma lucidum inhibit cytochrome P450 enzymes interfering with the metabolic process of specific clinical drugs. [PDF]

Front Pharmacol
Frontiers Production Office.
europepmc   +1 more source

Whole Genome Identification and Biochemical Characteristics of the Tilletia horrida Cytochrome P450 Gene Family. [PDF]

Int J Mol Sci
Wang Y, Shi Y, Li H, Wang S, Wang A.
europepmc   +1 more source

Characterization of Neonicotinoid Metabolites by Cytochrome P450-Mediated Metabolism in Poultry. [PDF]

Toxics
Dam-On A, Nimako C, Kulprasertsri S, Ikenaka Y, Yohannes YB, Nakayama SMM, Ishizuka M, Poapolathep S, Poapolathep A, Khidkhan K.   +9 more
europepmc   +1 more source

The role of the cytochrome P450 superfamily in the skin. [PDF]

Expert Rev Mol Med
Chen Q, Wang T, Wu X, Yuan H, Wei Y, Xiao Y.   +5 more
europepmc   +1 more source

Triterpenoids from Ganoderma lucidum inhibit cytochrome P450 enzymes interfering with the metabolic process of specific clinical drugs. [PDF]

Front Pharmacol
Li D, Lin Y, Lv X, Wu Y, Han C, Cao P, Zhang G, Leng A, Zhou J, Wang C.   +9 more
europepmc   +1 more source

Roles of Ferric Peroxide Anion Intermediates (Fe³⁺O₂ ^-, Compound 0) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Oxidation Model. [PDF]

Angew Chem Int Ed Engl
Tateishi Y, McCarty KD, Martin MV, Yoshimoto FK, Guengerich FP.   +4 more
europepmc   +1 more source

Adaptive evolution of invasive fall armyworms to maize with potential involvement of Cytochrome P450 genes. [PDF]

BMC Genomics
Yainna S, Hilliou F, Haenniger S, d'Alençon E, Brévault T, Nam K.   +5 more
europepmc   +1 more source