Results 221 to 230 of about 308,115 (327)

Small Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 Gene

, 2006
Jie Chen, Xiao-Xia Yang, Min Huang, Zeping Hu, Ming He, Wei Duan, Eli Chan, Fwu‐Shan Sheu, Xiao Chen, Shu-Feng Zhou   +9 more
openalex   +2 more sources

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

The Activation of Cytochrome P450 2C9 Is Facilitated by the Coenzyme Forms of Vitamin B2. [PDF]

Molecules
Koroleva PI, Kuzikov AV, Gilep AA, Ivanov SV, Archakov AI, Shumyantseva VV.   +5 more
europepmc   +1 more source

Characterization of a cytochrome P450 that catalyzes the O-demethylation of lignin-derived benzoates

Megan E Wolf, D.J. Hinchen, J.E. McGeehan, Lindsay D. Eltis   +3 more
openalex   +1 more source

The effects of fenbendazole, flubendazole and mebendazole on activities of hepatic cytochromes P450 in pig [PDF]

, 2004
Vendula Baliharová, J. Velík, M. Šavlík, Barbora Szotáková, J. Lamka, L. Tahotná, Lenka Skálová   +6 more
openalex   +1 more source

Population Pharmacokinetics Analysis of Talazoparib and Enzalutamide Combination Therapy for Patients With Metastatic Castration‐Resistant Prostate Cancer

The Journal of Clinical Pharmacology, EarlyView.
Abstract The poly(ADP‐ribose) polymerase inhibitor talazoparib, combined with the androgen receptor inhibitor enzalutamide is approved for patients with homologous recombination repair (HRR) gene‐mutated metastatic castration‐resistant prostate cancer (mCRPC) in the US and with mCRPC in whom chemotherapy is not clinically indicated in Europe.
Mark Hadigol, Jason H. Williams, Haihong Shi, Derek Z. Yang, Justin Hoffman, Diane D. Wang   +5 more
wiley   +1 more source

Estrogen associations with human pregnancy related increases in cytochrome P450 3A activity. [PDF]

Front Pharmacol
Fashe MM, Lee J, Grieco JT, Fallon JK, Mulrenin IR, Gower MN, Jackson KD, Boggess KA, Lee CR.   +8 more
europepmc   +1 more source

Synthesis of 2-methyl-5-methoxy-1,4-benzoquinone and In-silico Activity Profiling Toward Cytochrome P450-3A4

, 2019
Fath Dwisari, Arie Srihardyastutie, Siti Mariyah Ulfa   +2 more
openalex   +1 more source

Systematic review: Safety and efficacy of atomoxetine in children and adolescents with autism spectrum disorder

JCPP Advances, EarlyView.
This systematic review aimed to assess the current evidence on the efficacy and safety of Atomoxetine in common clinical symptoms of autism spectrum disorder (ASD) for children and adolescents. With limited studies available, there is a need for more high‐power studies for the use of Atomoxetine in children and adolescents with autism spectrum disorder.
Nihit Gupta, Daniel Boyes, Hunter Hanlon‐Taylor, Mayank Gupta   +3 more
wiley   +1 more source

Identification and Expression Analysis of the Cytochrome P450 Genes in <i>Phyllotreta striolata</i> and CYP6TH1/CYP6TH2 in the Involvement of Pyridaben Tolerance. [PDF]

Insects
Zhu Y, Liu Z, Mai W, Pu X, Mo H, Shu B, Wu Z.   +6 more
europepmc   +1 more source