Results 241 to 250 of about 506,903 (380)

Prevalence of Non–Cytochrome P450–Mediated Metabolism in Food and Drug Administration–Approved Oral and Intravenous Drugs: 2006–2015

Drug Metabolism And Disposition, 2016
M. Cerny
semanticscholar   +1 more source

In Vitro Assessment of Drug‐Induced Liver Injury Using Three‐Dimensional Cultured HepaSH Cells Derived From Chimeric Mouse Model With Humanized Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Drug‐induced liver injury (DILI) is a serious adverse event and a common cause of postmarketing drug withdrawal. Despite nonclinical assessments of DILI risk, which are predominantly conducted in experimental animals, DILI remains a frequent adverse event, highlighting the need to improve nonclinical assessments.
Xingming Liu, Yuichiro Higuchi, Yuta Sakamoto, Shota Yanagida, Shotaro Uehara, Hiroshi Suemizu, Yasunari Kanda, Hiroyuki Kawagishi   +7 more
wiley   +1 more source

Roles of Renal Cytochrome P450-Dependent Arachidonic Acid Metabolites in Hypertension.

, 1992
Ken Omata, Keishi Abe, Hsu-Lang Sheu, Kazunori Yoshida, E. Tsutsumi, KAORU YOSHINAGA, Nader G. Abraham, Michal L. Schwartzman   +7 more
openalex   +2 more sources

Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism

Drug Metabolism And Disposition, 2016
T. Tracy, Amarjit S. Chaudhry, B. Prasad, K. Thummel, E. Schuetz, Xiao-bo Zhong, Yun‐chen Tien, Hyunyoung Jeong, Xian Pan, L. Shireman, Jessica Tay-Sontheimer, Yvonne S. Lin   +11 more
semanticscholar   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles' antifungal activities. [PDF]

Nat Commun
Li W, Whiteway M, Hang S, Yu J, Lu H, Jiang Y.   +5 more
europepmc   +1 more source

Molecular Genetics of the Human Cytochrome P450-Dependent Monooxygenases.

, 1992
C. Roland Wolf, Colin Smith, Gillian Smith, A C Gough, Stewart Bryant, Nigel K. Spurr, David J. Harrison   +6 more
openalex   +2 more sources

Cloning of Wound-Induced Cytochrome P450 Monooxygenases Expressed in Pea [PDF]

, 1996
Michael R. Frank, J. M. Deyneka, Mary A. Schuler   +2 more
openalex   +1 more source

Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics

Drug Metabolism And Disposition, 2016
R. Foti, D. Dalvie
semanticscholar   +1 more source

Ultra‐Sensitive Quantification of Indoxyl Sulfate and 3‐Carboxy‐4‐Methyl‐5‐Propyl‐2‐Furanpropanoic Acid in Plasma Using Ultra‐Performance Liquid Chromatography Coupled to Quadrupole Time‐of‐Flight Mass Spectrometry

Journal of Clinical Laboratory Analysis, EarlyView.
We established and validated a novel ultra‐sensitive method for simultaneous quantification of uremic toxins using ultra‐performance liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry. This assay met the acceptance criteria of the U.S. Food and Drug Administration bioanalytical method validation guidance.
Jun Negami, Yosuke Suzuki, Haruki Sato, Daiki Toyama, Ayako Oda, Ryota Tanaka, Hiroyuki Ono, Tadasuke Ando, Toshitaka Shin, Hiroki Itoh, Keiko Ohno   +10 more
wiley   +1 more source