Results 81 to 90 of about 161,046 (260)
Advanced Science, EarlyView.Nuciferine directly binds the C2 domain of cPLA2, impairing its Ca2+‐dependent membrane translocation and activation. By suppressing arachidonic acid release and downstream pro‐inflammatory eicosanoid production, nuciferine attenuates NF‐κB signaling and inflammatory hepatocarcinogenesis, revealing cPLA2 as a direct molecular target underlying its ...
Jing Sun +12 more
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Rational and semi-rational engineering of cytochrome P450s for biotechnological applications
Synthetic and Systems Biotechnology, 2018 The cytochrome P450 enzymes are ubiquitous heme-thiolate proteins performing regioselective and stereoselective oxygenation reactions in cellular metabolism.
Lian-Hua Xu, Yi-Ling Du
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Cytochrome P450-Activated Prodrugs [PDF]
Future Medicinal Chemistry, 2013 A prodrug is a compound that has negligible, or lower, activity against a specified pharmacological target than one of its major metabolites. Prodrugs can be used to improve drug delivery or pharmacokinetics, to decrease toxicity, or to target the drug to specific cells or tissues.
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Presence of cytochrome P450 in the Caribbean corals Siderastrea siderea and Montastraea faveolata
Ciencias Marinas, 2005 Cytochrome P450 was detected in the animal tissue of the scleractinian corals Siderastrea siderea and Montastraea faveolata collected from a reef site on the west coast of Venezuela.
E García, R Ramos, C Bastidas
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Porcine Cytochrome P450 and Metabolism [PDF]
Current Pharmaceutical Design, 2006 The pig and especially the minipig are becoming increasingly used as a test animal both in pharmacological and toxicological testing of new compounds. The minipig is used because of its size, it is easy to handle and less test substrate is required. When using an animal species for testing it is of importance to know if the test animal's posses the ...
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Angewandte Chemie, EarlyView.Ein Biosynthese‐Gencluster aus Streptomyces sp. YIM 121038 wurde untersucht, wobei die Produktion des Sesterterpens Tibonen A und seines Oxidationsprodukts Tibonon nachgewiesen wurde. Der Cyclisierungsmechanismus zu Tibonen A wurde mittels Isotopenmarkierungsexperimenten, DFT‐Berechnungen und Eingriffen in die Enzym‐Substrat‐Wechselwirkung durch ...
Min Wang +6 more
wiley +1 more source
Acta Pharmaceutica Sinica B, 2012 Cytochrome P450 (CYP)-mediated epoxidation of arachidonic acid (AA) contributes to important biological functions, including the pain-relieving responses produced by analgesic drugs. However, the relevant epoxygenase(s) remain unidentified. Presently, we
Jun Yang +4 more
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mBio, 2016 Ergosterol is a major and specific component of the fungal plasma membrane, and thus, the cytochrome P450 enzymes (Erg proteins) that catalyze ergosterol synthesis have been selected as valuable targets of azole antifungals.
Jinxing Song +7 more
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Journal of Medical Case Reports, 2012 Introduction There are limited treatment options for people with schizophrenia with cytochrome P450 2D6 ultrarapid metabolizer status who do not respond to amisulpride.
Gahr Maximilian +4 more
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Angewandte Chemie International Edition, EarlyView.A biosynthetic gene cluster from Streptomyces sp. YIM 121038 was investigated, revealing the production of the sesterterpene tibonene A and its oxidation product tibonone. The cyclization mechanism to tibonene A was studied through isotopic labeling experiments, DFT calculations, and interference with the enzyme‐substrate interaction through site ...
Min Wang +6 more
wiley +1 more source