Results 81 to 90 of about 283,519 (305)
Advanced Science, EarlyView.This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang +10 more
wiley +1 more source
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Sains NaturalThe aim of this study was to evaluate the potential of brassicasterol found in mustard greens as a cytochrome P450 inhibitor using a computational approach.
Okta Suryani, Ade Irma Fahira
doaj +1 more source
Zhongguo shiyan zhenduanxue, 2023 细胞色素P450氧化还原酶缺乏症(cytochrome P450 oxidoreductase deficiency, PORD)是先天性肾上腺皮质增生症(congenital adrenal hyperplasia, CAH)中罕见的类型，为细胞色素 P450 氧化还原酶(cytochrome P450 oxidoreductase, POR)基因纯合或杂合变异引起的常染色体隐性遗传病。
李卓 +4 more
doaj
Membrane phospholipid augments cytochrome P4501a enzymatic activity by modulating structural conformation during detoxification of xenobiotics. [PDF]
PLoS ONE, 2013 Cytochrome P450 is a superfamily of membrane-bound hemoprotein that gets involved with the degradation of xenobiotics and internal metabolites. Accumulated body of evidence indicates that phospholipids play a crucial role in determining the enzymatic ...
Manik C Ghosh, Arun K Ray
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley +1 more source
Intronic polymorphisms of cytochromes P450
Human Genomics, 2010 The cytochrome P450 enzymes active in drug metabolism are highly polymorphic. Most allelic variants have been described for enzymes encoded by the cytochrome P450 family 2 (CYP2) gene family, which has 252 different alleles. The intronic polymorphisms in
Ingelman-Sundberg Magnus, Sim Sarah C
doaj +1 more source
Independent elaboration of steroid hormone signaling pathways in Metazoans [PDF]
, 2009 Steroid hormones regulate many physiological processes in vertebrates, nematodes and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors.
Barbara A. Demeneix +5 more
core +4 more sources
Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers
Advanced Science, EarlyView.This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu +9 more
wiley +1 more source
Advanced Science, EarlyView.A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen +11 more
wiley +1 more source