Results 81 to 90 of about 297,833 (301)

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Intensive Production of Carboxylic Acids Using C. butyricum in a Membrane Bioreactor (MBR)

Fermentation, 2018
This work reports on the use of a bench-scale chemostat (CSTR) in continuous mode and of a pilot-scale membrane bioreactor (MBR) in fed-batch mode to intensively produce acetic and butyric acids using C. butyricum grown on synthetic media.
Husnul Azan Tajarudin, Myrto-Panagiota Zacharof, Karnika Ratanapongleka, Paul M. Williams, Robert W. Lovitt   +4 more
doaj   +1 more source

Independent elaboration of steroid hormone signaling pathways in Metazoans [PDF]

, 2009
Steroid hormones regulate many physiological processes in vertebrates, nematodes and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors.
Laudet, Vincent, Vincent Laudet, Baker, Michael E., Chantal Dauphin-Villemant, Demeneix, Barbara A., Markov, Gabriel, V, Gabriel V. Markov, Demeneix, Ba, Tavares, Raquel, Michael E. Baker, Markov, Gv., Raquel Tavares, Barbara A. Demeneix, Dauphin-Villemante, C., Laudet, V., Dauphin-Villemant, Chantal, Tavares, R., Bakerf, Me.   +17 more
core   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

Isosteric Engineering of Enzymes: Overcoming Activity–Stability Trade‐Offs by Site‐Selective CH → N Substitutions

Angewandte Chemie, EarlyView.
Coupling biosynthetic noncanonical amino acid production with genetic code expansion enables site‐specific incorporation of azatryptophans into PET‐degrading enzymes (PETases). By isosteric single‐atom editing of a conserved tryptophan, AzaPETases break the activity–stability trade‐off, delivering higher catalytic efficiency at elevated temperature and
Elwy H. Abdelkader, Haocheng Qianzhu, Gottfried Otting, Thomas Huber   +3 more
wiley   +2 more sources

Effects of g-hexachlorocyclohexane and L-3,3',5- triiodothyronine on rat liver cytochrome P4502E1- dependent activity and content in relation to microsomal superoxide radical generation

Biological Research, 2003
Liver microsomal cytochrome P4502E1-dependent p-nitrophenol (PNP) hydroxylation and expression of cytochrome P4502E1 were studied in rats subjected to g-hexachlorocyclohexane (HCCH) or L-3,3,,5-triiodothyronine (T3) administration as a possible mechanism
VIRGINIA FERNÁNDEZ, LAURA MASSA, LUIS QUIÑONES, KARIN A SIMON-GIAVAROTTI, LEANDRO GIAVAROTTI, VÂNIA D'ALMEIDA, LIGIA A AZZALIS, VIRGINIA BC JUNQUEIRA, LUIS A VIDELA   +8 more
doaj  

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Inhibition of Human Cytochrome P450 Metabolism by Blended Herbal Products and Vitamins

Journal of Pharmacy & Pharmaceutical Sciences, 2011
Purpose. The use of supplements as herbal and micronutrient natural health products with conventional health products has become increasingly popular.
Teresa W Tam, Humayoun Akhtar, John Thor Arnason, Kosta Cvijovic, Heather Boon, D William Cameron, Cathy E Drouin, Walter Jaeger, Ross T Tsuyuki, Sunita Vohra, Brian C Foster   +10 more
doaj   +1 more source

Expressão heteróloga de citocromo P450 356A1 de Crassostrea gigas e utilização para biomonitoramento ambiental [PDF]

, 2010
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia, Florianópolis, 2010A ecotoxicologia é um dos ramos da ciência que cada vez mais ganha relevância internacional por
Silva, Christielly Rodrigues da
core  

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source