Results 91 to 100 of about 283,519 (305)

Effects of g-hexachlorocyclohexane and L-3,3',5- triiodothyronine on rat liver cytochrome P4502E1- dependent activity and content in relation to microsomal superoxide radical generation

Biological Research, 2003
Liver microsomal cytochrome P4502E1-dependent p-nitrophenol (PNP) hydroxylation and expression of cytochrome P4502E1 were studied in rats subjected to g-hexachlorocyclohexane (HCCH) or L-3,3,,5-triiodothyronine (T3) administration as a possible mechanism
VIRGINIA FERNÁNDEZ, LAURA MASSA, LUIS QUIÑONES, KARIN A SIMON-GIAVAROTTI, LEANDRO GIAVAROTTI, VÂNIA D'ALMEIDA, LIGIA A AZZALIS, VIRGINIA BC JUNQUEIRA, LUIS A VIDELA   +8 more
doaj  

Rational and semi-rational engineering of cytochrome P450s for biotechnological applications

Synthetic and Systems Biotechnology, 2018
The cytochrome P450 enzymes are ubiquitous heme-thiolate proteins performing regioselective and stereoselective oxygenation reactions in cellular metabolism.
Lian-Hua Xu, Yi-Ling Du
doaj   +1 more source

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data [PDF]

, 2014
To predict the tramadol in vivo pharmacokinetics in adults by using in vitro metabolism data and an in vitro-in vivo extrapolation (IVIVE)-linked physiologically-based pharmacokinetic (PBPK) modeling and simulation approach (SimcypA (R)).
Allegaert, Karel, Annaert, Pieter, Boussery, Koen, Colin, Pieter, Cuyckens, Filip, Mannens, Geert, Snoeys, Jan, T'jollyn, Huybrecht, Van Bocxlaer, Jan, Van Peer, Achiel, Vermeulen, An   +10 more
core   +1 more source

Glucosinolate and Isothiocyanate Profiles in Different Varieties of Raphanus sativus Seed via Multivariate Data Analysis

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Through HPLC–MS/MS analysis and multivariate statistics, raphani semen (RS) varieties with high functional components were screened. The white raphani semen “Xuebawang” was identified as ideal for further study due to its high bioactive content: glucoraphenin (9010.27 mg/100 g), glucoraphanin (1027.76 mg/100 g), sulforaphane (66.14 mg/100 g), and ...
Yonghua Li, Dongmei Lin, Peng Wu, Rui Gao, Jingxiu Bi, Yuying Jiang, Tong Zhao, Xuexia Yuan, Jianhan Xu, Pingxiang Liu, Yutao Wang   +10 more
wiley   +1 more source

Intensive Production of Carboxylic Acids Using C. butyricum in a Membrane Bioreactor (MBR)

Fermentation, 2018
This work reports on the use of a bench-scale chemostat (CSTR) in continuous mode and of a pilot-scale membrane bioreactor (MBR) in fed-batch mode to intensively produce acetic and butyric acids using C. butyricum grown on synthetic media.
Husnul Azan Tajarudin, Myrto-Panagiota Zacharof, Karnika Ratanapongleka, Paul M. Williams, Robert W. Lovitt   +4 more
doaj   +1 more source

Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker. [PDF]

, 2013
Profenofos is a direct acting phosphorothioate organophosphorus (OP) pesticide capable of inhibiting β-esterases such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase.
Chi, Lai-Har, Dadson, Oswald A, Ellison, Corie A, Farahat, Fayssal M, Farahat, Taghreed, Lein, Pamela J, McGarrigle, Barbara P, Olson, James R, Singleton, Steven T   +8 more
core   +1 more source

A comprehensive proteome and phosphoproteome atlas across nine organs of the Chinese hamster

Animal Models and Experimental Medicine, EarlyView.
This study presents the first comprehensive proteome and phosphoproteome atlas of the Chinese hamster across nine organs (heart, liver, lung, kidney, spleen, cerebral cortex, skeletal muscle, stomach, and testis or ovary). A total of 14 219 proteins were identified in the proteome, with 11 828 phosphorylated proteins and 47 122 phosphorylation sites ...
Luyao Zhang, Tao Ding, Wanjun Peng, Jie Kong, Xiaoyue Tang, Jiyu Xu, Qiaochu Wang, Zhiyi Zhang, Chunmei Shi, Yizhuo Tian, Huilan Yang, Yehong Yang, Yue Wu, Xiaoyan Liu, Jiangfeng Liu, Juntao Yang   +15 more
wiley   +1 more source

Inhibition of Human Cytochrome P450 Metabolism by Blended Herbal Products and Vitamins

Journal of Pharmacy & Pharmaceutical Sciences, 2011
Purpose. The use of supplements as herbal and micronutrient natural health products with conventional health products has become increasingly popular.
Teresa W Tam, Humayoun Akhtar, John Thor Arnason, Kosta Cvijovic, Heather Boon, D William Cameron, Cathy E Drouin, Walter Jaeger, Ross T Tsuyuki, Sunita Vohra, Brian C Foster   +10 more
doaj   +1 more source

Defining the Structural Consequences of Mechanism-Based Inactivation of Mammalian Cytochrome P450 2B4 Using Resonance Raman Spectroscopy [PDF]

, 2010
In view of the potent oxidizing strength of cytochrome P450 intermediates, it is not surprising that certain substrates can give rise to reactive species capable of attacking the heme or critical distal-pocket protein residues to irreversibly modify the ...
Hollenberg, Paul F., Kincaid, James R., Mak, Piotr J., Zhang, Haoming   +3 more
core   +2 more sources

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source