Results 91 to 100 of about 297,833 (301)
Rational and semi-rational engineering of cytochrome P450s for biotechnological applications
Synthetic and Systems Biotechnology, 2018 The cytochrome P450 enzymes are ubiquitous heme-thiolate proteins performing regioselective and stereoselective oxygenation reactions in cellular metabolism.
Lian-Hua Xu, Yi-Ling Du
doaj +1 more source
Cytochrome P450-Activated Prodrugs [PDF]
Future Medicinal Chemistry, 2013 A prodrug is a compound that has negligible, or lower, activity against a specified pharmacological target than one of its major metabolites. Prodrugs can be used to improve drug delivery or pharmacokinetics, to decrease toxicity, or to target the drug to specific cells or tissues.
openaire +4 more sources
Transcrição de genes citocromo P450 em ostra Crassostrea gigas [PDF]
, 2013 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia e Biociências, Florianópolis, 2013Diversas áreas costeiras no Estado de Santa Catarina estão associadas a zonas de ...
Gomes, Rafaela Pino
core
OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD
Advanced Science, EarlyView.This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li +11 more
wiley +1 more source
Presence of cytochrome P450 in the Caribbean corals Siderastrea siderea and Montastraea faveolata
Ciencias Marinas, 2005 Cytochrome P450 was detected in the animal tissue of the scleractinian corals Siderastrea siderea and Montastraea faveolata collected from a reef site on the west coast of Venezuela.
E García, R Ramos, C Bastidas
doaj +1 more source
Porcine Cytochrome P450 and Metabolism [PDF]
Current Pharmaceutical Design, 2006 The pig and especially the minipig are becoming increasingly used as a test animal both in pharmacological and toxicological testing of new compounds. The minipig is used because of its size, it is easy to handle and less test substrate is required. When using an animal species for testing it is of importance to know if the test animal's posses the ...
openaire +3 more sources
Dissecting the organ specificity of insecticide resistance candidate genes in Anopheles gambiae : known and novel candidate genes [PDF]
, 2014 Background The elevated expression of enzymes with insecticide metabolism activity can lead to high levels of insecticide resistance in the malaria vector, Anopheles gambiae.
Simon C Wagstaff +19 more
core +1 more source
Acta Pharmaceutica Sinica B, 2012 Cytochrome P450 (CYP)-mediated epoxidation of arachidonic acid (AA) contributes to important biological functions, including the pain-relieving responses produced by analgesic drugs. However, the relevant epoxygenase(s) remain unidentified. Presently, we
Jun Yang +4 more
doaj +1 more source
Erste Hinweise auf Ozonido‐TMC‐Komplexe von Eisen und Kobalt
Angewandte Chemie, EarlyView.Die Umsetzung der Eisen(II)‐Komplexe [(TMC)Fe(OTf)]BArF und [(D12‐TMC)Fe(OTf)]BArF sowie der Kobalt(II)‐Komplexe [(TMC)Co(OTf)]BArF und [(D12‐TMC)Co(X)]BArF (X = OTf, F) mit Ozon führt in einem 4:1‐Gemisch aus 2‐Me‐THF und THF bei Temperaturen bis −155°C zur Bildung von Ozonido‐ und Oxido‐Komplexen.
Stefan Schaub +14 more
wiley +1 more source
mBio, 2016 Ergosterol is a major and specific component of the fungal plasma membrane, and thus, the cytochrome P450 enzymes (Erg proteins) that catalyze ergosterol synthesis have been selected as valuable targets of azole antifungals.
Jinxing Song +7 more
doaj +1 more source