Results 171 to 180 of about 26,715 (257)

Borylcyclopropanes: Synthetic Strategies and Applications

open access: yesAngewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Entdeckung eines antiviralen Elektronentransferprozesses zur Erzeugung katalytisch selbstversorgender viraler Restriktionsfaktoren

open access: yesAngewandte Chemie, EarlyView.
CYB5R3 wird als mutmaßlicher Elektronentransferpartner von Viperin (RSAD2) identifiziert, was erklärt, warum die ER‐Lokalisation für die antivirale Aktivität erforderlich ist. Dieses Wissen ermöglichte die Entwicklung immunstiller, katalytisch selbstversorgender antiviraler Restriktionsfaktor‐Enzyme (iCAREs), die ein antivirales Nukleosidtriphosphat ...
Mengdi Wu   +16 more
wiley   +1 more source

Isosteric Engineering of Enzymes: Overcoming Activity–Stability Trade‐Offs by Site‐Selective CH → N Substitutions

open access: yesAngewandte Chemie, EarlyView.
Coupling biosynthetic noncanonical amino acid production with genetic code expansion enables site‐specific incorporation of azatryptophans into PET‐degrading enzymes (PETases). By isosteric single‐atom editing of a conserved tryptophan, AzaPETases break the activity–stability trade‐off, delivering higher catalytic efficiency at elevated temperature and
Elwy H. Abdelkader   +3 more
wiley   +2 more sources

Comparative proteome profiling of egg, larva and adult Hermetia illucens (Diptera: Stratiomyidae). [PDF]

open access: yesSci Rep
Saldivia P   +7 more
europepmc   +1 more source

Decoupled respiration in electro-active bacteria. [PDF]

open access: yesCommun Biol
Massazza DA, Busalmen JP, Romeo HE.
europepmc   +1 more source

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