Results 101 to 110 of about 9,325 (207)

Image_1_Validation of CyTOF Against Flow Cytometry for Immunological Studies and Monitoring of Human Cancer Clinical Trials.JPEG

, 2019
Flow cytometry is a widely applied approach for exploratory immune profiling and biomarker discovery in cancer and other diseases. However, flow cytometry is limited by the number of parameters that can be simultaneously analyzed, severely restricting ...
Sabelo Lukhele (3834571), Naoto Hirano (188272), Ben Wang (250897), Pam S. Ohashi (6710198), Marcus Butler (6457157), David G. Brooks (6710204), Cynthia J. Guidos (6710195), Bethany L. MacLeod (6710183), Albiruni R. Abdul Razak (4723662), Russell J. Dickson (6710186), Babak Noamani (461397), Tracy L. McGaha (6710192), Ramy Gadalla (3819166), Lillian L. Siu (6710201), Wenxi Xu (1517956), Heidi J. Elsaesser (6710189), Mengdi Guo (6457172)   +16 more
core   +1 more source

RNA-Seq and CyTOF immuno-profiling of regenerating lacrimal glands identifies a novel subset of cells expressing muscle-related proteins.

PLoS ONE, 2017
The purpose of the present studies was to use CyTOF and RNA-Seq technologies to identify cells and genes involved in lacrimal gland repair that could be targeted to treat diseases of lacrimal gland dysfunction.
Dillon Hawley, Jian Ding, Suharika Thotakura, Scott Haskett, Hema Aluri, Claire Kublin, Audrey Michel, Lisa Clapisson, Michael Mingueneau, Driss Zoukhri   +9 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, Volume 20, Issue 10, Page 2424-2448, October 2026.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

CD57-positive CD8 + T cells define the response to anti-programmed cell death protein-1 immunotherapy in patients with advanced non-small cell lung cancer

npj Precision Oncology
Immune checkpoint inhibitors have transformed the treatment landscape of non-small cell lung cancer (NSCLC). However, accurately identifying patients who will benefit from immunotherapy remains a challenge.
Wenjia Sun, Fengqi Qiu, Jing Zheng, Liangjie Fang, Jingjing Qu, Shumeng Zhang, Nan Jiang, Jianying Zhou, Xun Zeng, Jianya Zhou   +9 more
doaj   +1 more source

Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry

Cell Reports, 2018
Summary: We have performed an in-depth single-cell phenotypic characterization of high-grade serous ovarian cancer (HGSOC) by multiparametric mass cytometry (CyTOF).
Veronica D. Gonzalez, Nikolay Samusik, Tiffany J. Chen, Erica S. Savig, Nima Aghaeepour, David A. Quigley, Ying-Wen Huang, Valeria Giangarrà, Alexander D. Borowsky, Neil E. Hubbard, Shih-Yu Chen, Guojun Han, Alan Ashworth, Thomas J. Kipps, Jonathan S. Berek, Garry P. Nolan, Wendy J. Fantl   +16 more
doaj   +1 more source

Cellular census of human fibrosis defines functionally distinct stromal cell types and states

Nature Communications, 2020
New anti-fibrotics aided by a better understanding of fibrotic cell subsets and their functions are needed. Here the authors perform single-cell RNA-seq and CyTOF on nodules from patients with Dupuytren’s disease to map subsets and the state of ...
Thomas B. Layton, Lynn Williams, Fiona McCann, Mingjun Zhang, Marco Fritzsche, Huw Colin-York, Marisa Cabrita, Michael T. H. Ng, Marc Feldmann, Stephen N. Sansom, Dominic Furniss, Weilin Xie, Jagdeep Nanchahal   +12 more
doaj   +1 more source

immunoHuMiX: A personalizable gut‐on‐chip model for unraveling human microbiome–immune interactions

VIEW, Volume 7, Issue 5, October 2026.
The study introduces a personalized gut model that brings together human immune cells and intestinal cells to better mimic how the body interacts with microbes. This system successfully maintained both human cells and a 17‐strain probiotic community, showing consistent immune responses across different donors.
Charlotte De Rudder, Kacy Greenhalgh, Joanna Baginska, Camille Martin‐Gallausiaux, Léa Grandmougin, Rémy Villette, Mara Lucchetti, Bérénice Hansen, Marek Ostaszewski, Viacheslav A. Petrov, Koji Atarashi, Lena Weidert, Audrey Frachet Bour, Dominik Ternes, Javier Ramiro‐Garcia, Antoine Malabirade, Takeshi Tanoue, Marc Mac Giolla Eain, Elisabeth Letellier, Matthew Barrett, Jérôme Lacombe, Frederic Zenhausern, Coralie Guérin, Markus Ollert, Carole Seguin‐Devaux, Kenya Honda, Paul Wilmes   +26 more
wiley   +1 more source

CyTOF datasets for tadalafil PDAC study

<p><strong>CyTOF datasets accompanying the tadalafil study in PDAC mouse models (Gross NE and Zhang Z et al.)</strong></p> <p> </p> <p><strong>Original version: </strong><br>CyTOF ...
Ho, Won Jin, Gross, Nicole, Zhang, Zhehao   +2 more
core   +1 more source

Challenges in the Multivariate Analysis of Mass Cytometry Data: The Effect of Randomization [PDF]

, 2019
Cytometry by time-of-flight (CyTOF) has emerged as a high-throughput single cell technology able to provide large samples of protein readouts. Already, there exists a large pool of advanced high-dimensional analysis algorithms that explore the ...
Konstantinos Tsirlis, Georgios Papoutsoglou, Schmidt, A, Angelika Schmidt, Tegner, J,, Ioannis Tsamardinos, Tsirlis, K, Cabrero, D-G, Lagani, Vincenzo, Jesper Tegnér, Schmidt, Angelika, Gomez-Cabrero, David, David‐Gómez Cabrero, Tsamardinos, I, Tegner, Jesper, Vincenzo Lagani, Lagani, V, Papoutsoglou, Georgios, Tegner, J, Tsamardinos, Ioannis, Papoutsoglou, G, Tsirlis, Konstantinos   +21 more
core   +1 more source

Using mass cytometry to probe the STAT signaling landscape in circulating immune cells in Rheumatoid Arthritis uncovers signaling dysregulation and correlation with disease activity

Frontiers in Medicine
IntroductionThe phosphorylation state of signaling proteins is a useful measure of cell function. The high dimensionality of mass cytometry (CyTOF) allows assessment of a large number of parameters using limited amount of material.
Claudia Macaubas, Batuhan Bayram, Noor Hussein, Astraea Jager, Kara L. Davis, Jonathan Graf, Mary Nakamura, Devy Zisman, Devy Zisman, Elizabeth D. Mellins   +9 more
doaj   +1 more source