Results 81 to 90 of about 9,325 (207)
CYToF has significantly advanced immunophenotyping, especially in exploratory settings where comprehensive characterization of immune populations is necessary but sample sizes are limited. It is a powerful tool for single-cell immunological assays, particularly for the detailed and simultaneous analysis of diverse immune cell populations.
Meelad Amouzgar +5 more
openaire +1 more source
Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy
Cell Reports, 2019 Summary: The success of immunotherapy has led to a myriad of clinical trials accompanied by efforts to gain mechanistic insight and identify predictive signatures for personalization.
Felix J. Hartmann +13 more
doaj +1 more source
Allergy, EarlyView.ABSTRACT Allergic diseases arise from aberrant immune recognition of otherwise harmless environmental proteins and are driven by epitope‐specific interactions between allergens and the adaptive immune system. Although component‐resolved diagnostics have improved molecular characterisation of sensitization, they remain limited to whole‐allergen ...
Mark Møiniche +11 more
wiley +1 more source
CYToF has significantly advanced immunophenotyping, especially in exploratory settings where comprehensive characterization of immune populations is necessary but sample sizes are limited. It is a powerful tool for single-cell immunological assays, particularly for the detailed and simultaneous analysis of diverse immune cell populations.
Meelad Amouzgar +5 more
openaire +1 more source
Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir
eLife, 2020 The latent reservoir is a major barrier to HIV cure. As latently infected cells cannot be phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we describe a method that leverages high-dimensional phenotyping using CyTOF
Jason Neidleman +23 more
doaj +1 more source
Spatial Transcriptomics Identifies Characteristic Immunological Niches in Atopic Dermatitis
Allergy, EarlyView.Spatially organized immune niches containing mature migratory dendritic cells (mmDCs) and CD4+ T cells in atopic dermatitis lesions support localized T cell activation and may contribute to disease persistence. Spatial transcriptomics identifies conserved immune niches in atopic dermatitis lesions, characterized by close co‐localization of CD4+ T cells
Lina Gross +11 more
wiley +1 more source
A phase IIa study of the anti‐PD‐L1 antibody avelumab in relapsed/refractory PTCL: The AVAIL‐T trial
British Journal of Haematology, EarlyView.The AVAIL‐T study, the first evaluation of programmed death ligand 1 (PD‐L1) blockade in relapsed/refractory peripheral T‐cell lymphomas (PTCL), demonstrated limited single agent activity with durable responses seen in a minority. Circulating tumour DNA revealed distinct mutational dynamics and mass cytometry identified perturbed T‐cell subsets ...
Matthew J. Ahearne +28 more
wiley +1 more source
Antibodies used for Bac-CyTOF.
In vivo single-cell approaches have transformed our understanding of the immune populations in tissues. Mass cytometry (CyTOF), that combines the resolution of mass spectrometry with the ability to conduct multiplexed measurements of cell molecules at ...
Amy Dumigan (4576534) +4 more
core +1 more source
, 2019 Chemotherapy and radiotherapy are main adjuvant therapies for the treatment of gastric cancer, the treatment effects are individual difference, but the specific mechanism is unknown.
Yu, Weifang, +13 more
core +1 more source
CyTOF and CITE-seq T1D B cell normalized data set
, 2022 Insulin and Tetanus binding B cells were collected via MACS sorting for analysis using CyTOF (cytometry by time of flight). Data was then analyzed using unsupervised clustering and manual gating to find unique phenotypes and populations associated with ...
Stensland, Z (via Mendeley Data) +1 more
core +1 more source