Results 61 to 70 of about 9,325 (207)

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

CyTOF T1D B cell normalized data set

, 2022
Insulin and Tetanus binding B cells were collected via MACS sorting for analysis using CyTOF (cytometry by time of flight). Data was then analyzed using unsupervised clustering and manual gating to find unique phenotypes and populations associated with ...
Stensland, Z (via Mendeley Data)
core   +1 more source

A Bayesian feature allocation model for identifying cell subpopulations using CyTOF data [PDF]

, 2023
A Bayesian feature allocation model (FAM) is presented for identifying cell subpopulations based on multiple samples of cell surface or intracellular marker expression level data obtained by cytometry by time of flight (CyTOF).
Rezvani, Katy, Rafet Basar, Katy Rezvani, Lee, Juhee, Basar, Rafet, Daher, May, Juhee Lee, Lui, Arthur, May Daher, Arthur Lui, Peter F Thall, Thall, Peter F   +11 more
core   +1 more source

Comprehensive Immunoprofiling of Pediatric Zika Reveals Key Role for Monocytes in the Acute Phase and No Effect of Prior Dengue Virus Infection

Cell Reports, 2020
Summary: Zika virus (ZIKV) is an emerging, mosquito-borne flavivirus responsible for recent epidemics across the Americas, and it is closely related to dengue virus (DENV). Here, we study samples from 46 DENV-naive and 43 DENV-immune patients with RT-PCR-
Daniela Michlmayr, Eun-Young Kim, Adeeb H. Rahman, Rohit Raghunathan, Seunghee Kim-Schulze, Yan Che, Selim Kalayci, Zeynep H. Gümüş, Guillermina Kuan, Angel Balmaseda, Andrew Kasarskis, Steven M. Wolinsky, Mayte Suaréz-Fariñas, Eva Harris   +13 more
doaj   +1 more source

Spatial Au+ Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes

Advanced Science, EarlyView.
The first report of spatial Au+ mapping of a representative gold complex (Au9). Macrophages, DCs, and tumor cells ranked as the top three in Au+ enrichment after Au9 treatment. Interestingly, Au9 treatment could induce ferroptosis and suppress cellular cholesterol, further eliciting a self‐amplifying anti‐tumor immunity loop.
Zhongren Xu, Zhiyue Fan, Lin Lv, Wei Lu, Zhenfan Wen, Wukun Liu   +5 more
wiley   +1 more source

CyTOF confirms the expansion of innate and adaptive immune cells in the murine meninges during chronic T. brucei infection.

, 2023
(A) Overview of the experimental approach applied in this work. An anti-CD45-PE antibody was injected i.v. prior to cull, followed by magnetic sorting using anti-PE antibodies to obtain a fraction of resident meningeal cells that were used as input for ...
Lalit Kumar Dubey (5758280), Juan F. Quintana (8044493), Nono-Raymond Kuispond Swar (17420082), Gail McConnell (2180448), Michael Haley (7646750), Neil A. Mabbott (7361273), Luis de Lecea (711657), Annette MacLeod (12779), Matthew C. Sinton (11056182), Praveena Chandrasegaran (17420073), David Bending (17420085), Moumen Al Samman (17420079), John Ogunsola (17420076), Dieudonné Mumba Ngoyi (7889651)   +13 more
core   +1 more source

Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens

Scientific Reports, 2021
Single-cell level analysis is powerful tool to assess the heterogeneity of cellular components in tumor microenvironments (TME). In this study, we investigated immune-profiles using the single-cell analyses of endoscopically- or surgically-resected ...
Yukie Kashima, Yosuke Togashi, Shota Fukuoka, Takahiro Kamada, Takuma Irie, Ayako Suzuki, Yoshiaki Nakamura, Kohei Shitara, Tatsunori Minamide, Taku Yoshida, Naofumi Taoka, Tatsuya Kawase, Teiji Wada, Koichiro Inaki, Masataka Chihara, Yukihiko Ebisuno, Sakiyo Tsukamoto, Ryo Fujii, Akihiro Ohashi, Yutaka Suzuki, Katsuya Tsuchihara, Hiroyoshi Nishikawa, Toshihiko Doi   +22 more
doaj   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis

Acta Neuropathologica Communications, 2020
Myeloid cells contribute to inflammation and demyelination in the early stages of multiple sclerosis (MS), but it is still unclear to what extent these cells are involved in active lesion formation in progressive MS (PMS).
Chotima Böttcher, Marlijn van der Poel, Camila Fernández-Zapata, Stephan Schlickeiser, Julia K. H. Leman, Cheng-Chih Hsiao, Mark R. Mizee, Adelia, Maria C. J. Vincenten, Desiree Kunkel, Inge Huitinga, Jörg Hamann, Josef Priller   +12 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source