Results 51 to 60 of about 9,325 (207)

Supporting data for Fig 1G—Frequency of various immune cell subsets in the meninges quantified by CyTOF.

, 2023
Supporting data for Fig 1G—Frequency of various immune cell subsets in the meninges quantified by CyTOF.
Lalit Kumar Dubey (5758280), Juan F. Quintana (8044493), Nono-Raymond Kuispond Swar (17420082), Gail McConnell (2180448), Michael Haley (7646750), Neil A. Mabbott (7361273), Luis de Lecea (711657), Annette MacLeod (12779), Matthew C. Sinton (11056182), Praveena Chandrasegaran (17420073), David Bending (17420085), Moumen Al Samman (17420079), John Ogunsola (17420076), Dieudonné Mumba Ngoyi (7889651)   +13 more
core   +1 more source

Immune dysregulation in Glycogen Storage Disease 1b - a CyTOF approach

, 2023
Abstract Glycogen Storage Disease type 1b (GSD1b) is a rare disease manifesting as hypoglycemia, recurrent infections and neutropenia, resulting from deleterious mutations in the SLC37A4 gene encoding the glucose-6-phosphate transporter. The susceptibility to infections is thought to be attributed not only to the neutrophil defect, though ...
Arne Gehlhaar, Dror Shouval, Eduardo Gonzalez Santiago, Galina Ling, Blake McCourt, Lael Werner, Baruch Yerushalmi, Liza Konnikova   +7 more
openaire   +2 more sources

CyTOF protocol for immune monitoring of solid tumors from mouse models

STAR Protocols, 2023
Techniques for robust immune profiling of mouse tumor and blood are key to understanding immunological responses in mouse models of cancer. Here, we describe mass cytometry (cytometry by time-of-flight) procedures to facilitate high-parameter profiling of low-volume survival blood samples and end-of-study tumor samples.
Sarah M. Shin, Alexei Hernandez, Erin Coyne, Kabeer Munjal, Nicole E. Gross, Soren Charmsaz, Xuan Yuan, Hongqui Yang, Won Jin Ho   +8 more
openaire   +3 more sources

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Raw CyTOF images associated with Moldoveanu et al. 2022, Science Immunology

, 2022
This dataset contains the raw CyTOF images associated with the paper "An In-depth Map of the Melanoma Immune Microenvironment and Correlates of Immunotherapy Response by Imaging Mass Cytometry" (Moldoveanu et al. 2022).
Meterissian, Sarkis, Costantino, Santiago, Del Rincon, Sonia V., Mihalcioiu, Catalin, Lapointe, Réjean, Moldoveanu, Dan, Anderson-Trocme, Luke, Richardson, Keith, Alkallas, Rached, Petrecca, Kevin, Wang, Beatrice, Jamal, Rahima, Watters, Kevin, Zuo, Dongmei, Bertos, Nicholas R., Ramsay, LeeAnn, Meguerditchian, Ari-Nareg, Miller, Wilson H. Jr, Watson, Ian R., Moraes, Cleber, Richer, Martin J., Berry, Diana, Lingrand, Marine, Spatz, Alan, Turcotte, Simon, Lund, Amanda W., Rajkumar, Shivshankari, Xu, Eric, Tremblay, Francine, Wei, Yuhong, Perus, Lucas, Stagg, John, Dankner, Matthew, Mes-Masson, Anne-Marie, Guiot, Marie-Christine, Gravel, Simon, Lajoie, Mathieu, Najafabadi, Hamed S., Quail, Daniela F., Chergui, May, Dumitra, Sinziana   +40 more
core   +1 more source

Automated cell type annotation and exploration of single-cell signaling dynamics using mass cytometry

iScience
Summary: Mass cytometry by time-of-flight (CyTOF) is an emerging technology allowing for in-depth characterization of cellular heterogeneity in cancer and other diseases. Unfortunately, high-dimensional analyses of CyTOF data remain quite demanding. Here,
Dimitrios Kleftogiannnis, Sonia Gavasso, Benedicte Sjo Tislevoll, Nisha van der Meer, Inga K.F. Motzfeldt, Monica Hellesøy, Stein-Erik Gullaksen, Emmanuel Griessinger, Oda Fagerholt, Andrea Lenartova, Yngvar Fløisand, Jan Jacob Schuringa, Bjørn Tore Gjertsen, Inge Jonassen   +13 more
doaj   +1 more source

Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine

Nature Communications, 2022
Vaccination against COVID-19 has shown activation of different immune cell types. Here the authors characterise the immune response to the SARS-CoV-2 mRNA vaccine using longitudinal CyTOF single cell approaches to characterise antigen specific B and T ...
Kevin J. Kramer, Erin M. Wilfong, Kelsey Voss, Sierra M. Barone, Andrea R. Shiakolas, Nagarajan Raju, Caroline E. Roe, Naveenchandra Suryadevara, Lauren M. Walker, Steven C. Wall, Ariana Paulo, Samuel Schaefer, Debolanle Dahunsi, Camille S. Westlake, James E. Crowe, Robert H. Carnahan, Jeffrey C. Rathmell, Rachel H. Bonami, Ivelin S. Georgiev, Jonathan M. Irish   +19 more
doaj   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasis

JCI Insight, 2022
No disease-modifying drug exists for osteoarthritis (OA). Despite success in animal models, candidate drugs continue to fail in clinical trials owing to the unmapped interpatient heterogeneity and disease complexity.
Neety Sahu, Fiorella Carla Grandi, Nidhi Bhutani   +2 more
doaj   +1 more source

Characterization of adipose depot-specific stromal cell populations by single-cell mass cytometry

iScience, 2022
Summary: The increased prevalence of obesity and metabolic diseases has heightened interest in adipose tissue biology and its potential as a therapeutic target.
Ju Hee Lee, Kafi N. Ealey, Yash Patel, Navkiran Verma, Nikita Thakkar, So Young Park, Jae-Ryong Kim, Hoon-Ki Sung   +7 more
doaj   +1 more source