Results 91 to 100 of about 98,067 (307)

P48 | LONG-TERM PROGRESSION-FREE SURVIVAL BENEFIT WITH CILTACABTAGENE AUTOLEUCEL IN STANDARD-RISK RELAPSED/REFRACTORY MULTIPLE MYELOMA

Haematologica
Introduction. CARTITUDE-4 (NCT04181827) enrolled patients with lenalidomide-refractory multiple myeloma (MM) after 1–3 prior lines of therapy (pLOT) and showed a significant benefit of ciltacabtagene autoleucel (cilta-cel) over established triplet ...
D. Dytfeld, L.J. Costa, A. Oriol, S. Manier, P.M. Voorhees, Y. Lin, M. Htut, W. Roeloffzen, P. J. Ho, U. Shah, M. Zhao, Q. Li, A. Balogh, K. Li, A. Slaughter, N. Benachour, C. Lonardi, A. Ghosh, H. Sun, N. Lendvai, T. Lengil, N. Patel, M. Koneru, E. Florendo, O. Costa Filho, V. Mahajan, P. Rodríguez-Otero, C. Strouse, A.K. Stewart, S. Sidana   +29 more
doaj   +1 more source

Valorization of fruit pits from Prunus laurocerasus and Prunus cerasifera as agro‐food byproducts: Bioactive properties and safety assessment for potential food additive applications

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Food additives are widely used to extend the shelf life of foods and maintain their quality. In this study, the potential of Prunus laurocerasus and Prunus cerasifera fruit pits (endocarp and seed) as food additives was investigated in terms of cytotoxicity, antigenotoxicity, antioxidant activity, enzymatic anti‐browning, and urease
Zühal Bayrakçeken Güven, Mehmet Karadayı, Mustafa Abdullah Yilmaz, Osman Tugay, Oguz Cakir   +4 more
wiley   +1 more source

Impact of brief telehealth interventions on parental stress and challenging behaviors of children with fragile X syndrome

Orphanet Journal of Rare Diseases
Background Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability (ID) with comorbid autism and several support requirements.
María Francisca Miranda, Víctor Faundes, María Angélica Alliende, Lorena Santa María   +3 more
doaj   +1 more source

Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease [PDF]

, 2014
© 2014 John Wiley & Sons Ltd. Defining the prognosis of individual cancer sufferers remains a significant clinical challenge. Here we assessed the ability of high-resolution single telomere length analysis (STELA), combined with an experimentally ...
Allan, James M., Allsup, David J., Bailey, James, Baird, Duncan M., Britt-Compton, Bethan, Cawkwell, Lynn, Fegan, Chris, Grimstead, Julia W., Heppel, Nicole H., Hills, Robert, Jones, Rhiannon E., Lin, Thet Thet, Norris, Kevin, Pepper, Chris, Pratt, Guy   +14 more
core   +1 more source

Nanopharmaceutical Approach for Enhanced Anti-cancer Activity of Betulinic Acid in Lung-cancer Treatment via Activation of PARP: Interaction with DNA as a Target -Anti-cancer Potential of Nano-betulinic Acid in Lung Cancer-

Journal of Pharmacopuncture, 2016
Objectives: This study examined the relative efficacies of a derivative of betulinic acid (dBA) and its poly (lactide- co-glycolide) (PLGA) nano-encapsulated form in A549 lung cancer cells in vivo and in co-mutagen [sodium arsenite (SA) + benzo]undefined[
Jayeeta Das, Asmita Samadder, Sreemanti Das, Avijit Paul, Anisur Rahman Khuda-Bukhsh   +4 more
doaj   +1 more source

Dipteran chromosomes: a simple method for obtaining high quality chromosomal preparations [PDF]

, 2014
For cytogenetic studies it is necessary to develop an efficient method of chromosome preparation with wellpreserved and dispersed chromosomes and little or no cell-wall debris.
Bressa, Maria Jose, Chirino, Monica Gabriela, Luaces, Juan Pablo, Merani, Maria Susana, Rossi, Luis Francisco   +4 more
core  

Quantitative Imaging of Pyruvate Metabolism in a Patient With Anaplastic Thyroid Cancer

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Magnetic resonance imaging using hyperpolarized (HP) [1‐13C]‐pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi‐quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular ...
James A. Bankson, Joshua S. Niedzielski, Collin J. Harlan, Yunyun Chen, Christopher M. Walker, Philip L. Lorenzi, Lin Tan, Vikas Kundra, Matthew E. Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B. Peterson, Clifton D. Fuller, Vlad C. Sandulache, Stephen Y. Lai   +18 more
wiley   +1 more source

Assessment of Molecular Cytogenetic Methods for the Detection of Chromosomal Abnormalities [PDF]

, 2006
Some marker chromosomes and chromosome rearrangements are difficult to identify using G-bands by Giemsa staining after trypsin treatment (G-banding) alone.
Maruyama, Hidehiko, Morishima, Tsuneo, Ninomiya, Shinsuke, Shinozuka, Masako, Une, Tomoka, Yokoyama, Yuji   +5 more
core   +1 more source

A Case Report of a Special Type of Multiple Myeloma: Kappa Light Chain‐Only

Organ Medicine, EarlyView.
This case illustrates the clinical course of a patient diagnosed with kappa light chain‐only multiple myeloma, a rare subtype of multiple myeloma. Of note, light chain multiple myeloma is characterized by rapid disease progression and severe target organ damage.
Yanhua Dai, Yuanyue Guan, Shiwei Cui, Yuan Gao, Zhipeng Zhao, Rui Li, Li Song, Xiuying Zhao, Runqing Li   +8 more
wiley   +1 more source

Whole Genome Sequencing in Prenatal Diagnostics: The Danish Approach to Guideline Formation and Implementation Within Public Healthcare

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To describe the implementation of whole genome sequencing (WGS) in prenatal diagnostics and outline the national guideline system facilitating this. Methods Clinical guidelines for WGS in prenatal diagnostics were developed and implemented by the Danish Fetal Medicine Society.
Ida Vogel, Lotte Andreasen, Marie Balslev‐Harder, Naja Becher, Anja Ernst, Kasper Gadsbøll, Tina Duelund Hjortshøj, Marie Skov Hvidbjerg, Martin Larsen, Stina Lou, Ida Charlotte Bay Lund, Lars Henning Pedersen, Laura Kirstine Sønderberg Roos, Lene Sperling, Lone Sunde, Pernille Mathiesen Tørring, Cathrine Vedel, Olav Bjørn Petersen   +17 more
wiley   +1 more source