Results 151 to 160 of about 1,677 (171)

Cytoglobin has potent superoxide dismutase function

Proceedings of the National Academy of Sciences, 2021
Significance We identified a novel function of cytoglobin (Cygb) as an efficient superoxide dismutase (SOD) with a high–bimolecular dismutation rate on the order of 10 8 M −1 ⋅ s −1 .
Jay L. Zweier, Craig Hemann, Tapan Kundu, Mohamed G. Ewees, Sahar A. Khaleel, Alexandre Samouilov, Govindasamy Ilangovan, Mohamed A. El-Mahdy   +7 more
openaire   +2 more sources

Reactions of ferrous neuroglobin and cytoglobin with nitrite under anaerobic conditions

Journal of Inorganic Biochemistry, 2008
: Recent evidence suggests that the reaction of nitrite with deoxygenated hemoglobin and myoglobin contributes to the generation of nitric oxide and S-nitrosothiols in vivo under conditions of low oxygen availability. We have investigated whether ferrous
Angela Fago, Sylvia Dewilde
exaly   +2 more sources

Expression and biological role of cytoglobin in human ovarian cancer

Tumor Biology, 2014
Loss of cytoglobin is found to be involved in the progression of several human cancers. However, its expression pattern and biological roles in human ovarian cancers are not clear. In this study, we examined cytoglobin expression in 118 archived ovarian cancer specimens using immunohistochemistry.
Haiying, Chen, Xia, Zhao, Tao, Meng
exaly   +3 more sources

Structural Basis of Human Cytoglobin for Ligand Binding

Journal of Molecular Biology, 2004
Cytoglobin (Cgb), a newly discovered member of the vertebrate globin family, binds O(2) reversibly via its heme, as is the case for other mammalian globins (hemoglobin (Hb), myoglobin (Mb) and neuroglobin (Ngb)). While Cgb is expressed in various tissues, its physiological role is not clearly understood.
Hiroshi, Sugimoto, Masatomo, Makino, Hitomi, Sawai, Norifumi, Kawada, Katsutoshi, Yoshizato, Yoshitsugu, Shiro   +5 more
openaire   +2 more sources

Regulation and Role of Neuroglobin and Cytoglobin Under Hypoxia

2007
Neuroglobin (Ngb) and cytoglobin (Cygb) are two novel members of the globin superfamily that are ubiquitously present in vertebrates. Their exact physiological roles are still uncertain. Here we review the expression of Ngb and Cygb, with particular emphasis on their regulation and potential role under hypoxia. Ngb expression is confined to neurons and
Thorsten, Burmester, Frank, Gerlach, Thomas, Hankeln   +2 more
openaire   +2 more sources

Abstract 18863: Emerging Role of Cytoglobin in Cardiovascular Function and Regulation: Evidence From Cytoglobin Knockout Mice

Circulation, 2013
Cytoglobin (Cygb), a recently identified globin protein, is reported to play an important role in O 2 -dependent nitric oxide (NO) removal, nitrite reduction and NO production; and it is thought to be involved in vascular function.
M A Hassan Talukder, Raed S Ismail, Mohamed A El-Mahdy, Le T Thuy, Norifumi Kawada, Jay L Zweier   +5 more
openaire   +1 more source

Analyses of Expression of Cytoglobin by Immunohistochemical Studies in Human Tissues

Hemoglobin, 2008
Cytoglobin (Cygb) is a recently discovered member of the vertebrate globin family, which includes probably most extensively studied proteins, hemoglobin (Hb), myoglobin (Mb) and neuroglobin (Ngb). It has been reported that Cygb is expressed ubiquitously at the mRNA or protein level.
Seiji Yanai, Hiromi Mukaide
exaly   +3 more sources

CYTOGLOBIN IN FREQUENCY PHOTOBIOMODULATION OF CHONDROCYTES

Proceedings of the International Conference NT+ME`25 (Gurzuf, from June 1 to June 8, 2025)
Diagnostics of the signaling network in chondrocytes revealed the effectiveness of pulsed laser radiation (1560nm, 5 Hz) in relation to proteoglycan synthesis under normoxia conditions. It is assumed that the target of frequency photobiomodulation is a dynamic cytoglobin complex with a nuclear membrane that regulates its distribution between the ...
O.I. Baum, A.K. Dmitriev, O.A. Tiflova
openaire   +1 more source

The Role Of Cytoglobin In The Plasma-Treatment Of Melanoma

Clinical Plasma Medicine, 2018
Globins are ancient proteins that are present in all kingdoms of life. At the moment, there are 8 different globins known in vertebrates with distinct expression patterns. Human cytoglobin (CYGB), a member of this globin superfamily, is a hexacoordinated heme-protein that is mostly expressed in fibroblasts and fibroblast-related cells, but is also ...
Joey De Backer, Jamoliddin Razzokov, Dietmar Hammerschmid, Carl Mensch, Naresh Kumar, Annemie Bogaerts, Sylvia Dewilde   +6 more
openaire   +1 more source

Protection From Ischemic Cell Death by the Induction of Cytoglobin

Transplantation Proceedings, 2005
Methods to reduce beta-cell loss after islet isolation and transplantation must be developed if islet transplantation is to become a preferred treatment for diabetes. Most recent research has focused on the reduction of toxicity from immunosuppressants and the enhancement of revascularization by growth factors such as vascular endothelial growth factor.
J I, Stagner, S N, Parthasarathy, K, Wyler, R N, Parthasarathy   +3 more
openaire   +2 more sources