Results 181 to 190 of about 2,444 (195)

Reactivity of Recombinant Cytoglobin with Peroxides and Amyloid Structure in Peroxide-Activated Cytoglobin

Free Radical Biology and Medicine, 2016
Introduction Cytoglobin (Cygb) is a member of the globin superfamily, and it is expressed at different levels in many tissues, such as neurons, fibroblasts and connective tissue. The biological role played by Cygb is not well established and different functions have been postulated.
Juliana Conrado Ferreira, Thyago Cardoso, Otaciro Nascimento, Wael Rabeh, Iseli Nantes   +4 more
openaire   +1 more source

Characterization of human cytoglobin gene promoter region

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2006
Cytoglobin (CYGB) is a member of the vertebrate globin family together with hemoglobin, myoglobin and neuroglobin. Although the physiological function of CYGB is still unclear, spectroscopic studies show that CYGB contains a hexacoordinated heme pocket similar to other pentacoordinated globin proteins.
Guo, X, Philipsen, S, TanUn, KC
openaire   +5 more sources

Structural Basis of Human Cytoglobin for Ligand Binding

Journal of Molecular Biology, 2004
Cytoglobin (Cgb), a newly discovered member of the vertebrate globin family, binds O(2) reversibly via its heme, as is the case for other mammalian globins (hemoglobin (Hb), myoglobin (Mb) and neuroglobin (Ngb)). While Cgb is expressed in various tissues, its physiological role is not clearly understood.
Hiroshi, Sugimoto, Masatomo, Makino, Hitomi, Sawai, Norifumi, Kawada, Katsutoshi, Yoshizato, Yoshitsugu, Shiro   +5 more
openaire   +3 more sources

Expression, Purification, and Crystallization of Neuro- and Cytoglobin

2008
Neuroglobin and cytoglobin, members of the globin family, are present in vertebrate cells at very low concentrations. As the function of both proteins is still a matter of debate, it is very important to be able to produce and purify these proteins, and in general all members of the globin family, to homogeneity.
DEWILDE S, MEES K, KIGER L, LECHAUVE C, MARDEN M, PESCE, ALESSANDRA, BOLOGNESI M, MOENS L.   +7 more
openaire   +6 more sources

Neuroglobin and Cytoglobin expression in the human brain

Brain Structure and Function, 2012
Neuroglobin and cytoglobin are new members of the heme-globin family. Both globins are primarily expressed in neurons of the brain and retina. Neuroglobin and cytoglobin have been suggested as novel therapeutic targets in various neurodegenerative diseases based on their oxygen binding and cell protecting properties.
Hundahl, Christian Ansgar, Kelsen, Jesper, Hay-Schmidt, Anders   +2 more
openaire   +3 more sources

Neuroglobin and cytoglobin as potential enzyme or substrate

Gene, 2007
The possible enzymatic activities of neuro- and cytoglobin as well as their potential function as substrates in enzymatic reactions were studied. Neuro- and cytoglobin are found to show no appreciable superoxide dismutase, catalase, and peroxidase activities.
F. Trandafir, D. Hoogewijs, ALTIERI, Fabio, P. Rivetti Di Val Cervo, K. Ramser, S. Van Doorslaer, J. R. Vanfleteren, L. Moens, S. Dewilde   +8 more
openaire   +4 more sources

Abstract 18863: Emerging Role of Cytoglobin in Cardiovascular Function and Regulation: Evidence From Cytoglobin Knockout Mice

Circulation, 2013
Cytoglobin (Cygb), a recently identified globin protein, is reported to play an important role in O 2 -dependent nitric oxide (NO) removal, nitrite reduction and NO production; and it is thought to be involved in vascular function.
M A Hassan Talukder, Raed S Ismail, Mohamed A El-Mahdy, Le T Thuy, Norifumi Kawada, Jay L Zweier   +5 more
openaire   +1 more source

CYTOGLOBIN IN FREQUENCY PHOTOBIOMODULATION OF CHONDROCYTES

Proceedings of the International Conference NT+ME`25 (Gurzuf, from June 1 to June 8, 2025)
Diagnostics of the signaling network in chondrocytes revealed the effectiveness of pulsed laser radiation (1560nm, 5 Hz) in relation to proteoglycan synthesis under normoxia conditions. It is assumed that the target of frequency photobiomodulation is a dynamic cytoglobin complex with a nuclear membrane that regulates its distribution between the ...
O.I. Baum, A.K. Dmitriev, O.A. Tiflova
openaire   +1 more source

Regulation and Role of Neuroglobin and Cytoglobin Under Hypoxia

2007
Neuroglobin (Ngb) and cytoglobin (Cygb) are two novel members of the globin superfamily that are ubiquitously present in vertebrates. Their exact physiological roles are still uncertain. Here we review the expression of Ngb and Cygb, with particular emphasis on their regulation and potential role under hypoxia. Ngb expression is confined to neurons and
Thorsten, Burmester, Frank, Gerlach, Thomas, Hankeln   +2 more
openaire   +2 more sources

Thyroid hormone modulates neuroglobin and cytoglobin in rat brain

Metabolic Brain Disease, 2015
Thyroid hormones (THs) are essential and crucial for brain development, playing a role in growth and differentiation. Two globins named neuroglobin (Ngb) and cytoglobin (Cygb) are located in the brain, and each one has different distribution and function: They seem to have similar action by providing O(2) for respiratory chain, and detoxification of ...
Kelen Carneiro, Oliveira, Rodrigo Rodrigues, da Conceição, Gisele Constantinov, Piedade, Janaina Sena, de Souza, Monica Akemi, Sato, Rui Monteiro, de Barros Maciel, Gisele, Giannocco   +6 more
openaire   +2 more sources