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Multi‑omics approach to improve patient‑tailored therapy using immune checkpoint blockade and cytokine‑induced killer cell infusion in an elderly patient with lung cancer: A case report and literature review. [PDF]

Oncol Lett
Xing Y, Qin F, Han L, Yang J, Zhang H, Qi Y, Tu S, Zhai Y.   +7 more
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Cancer Immunotherapy with Cytokine-Induced Killer Cells

Targeted Oncology, 2017
Cytokine-induced killer (CIK) cells form under certain stimulation conditions in cultures of peripheral blood mononuclear cells (PBMCs). They are a heterogeneous immune cell population and contain a high percentage of cells with a mixed T-NK phenotype (CD3+CD56+).
Juan J, Mata-Molanes, Manuel, Sureda González, Belén, Valenzuela Jiménez, Elena Mª, Martínez Navarro, Antonio, Brugarolas Masllorens   +4 more
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Promising immunotherapy: Highlighting cytokine‐induced killer cells

Journal of Cellular Biochemistry, 2018
AbstractFor many years, cancer therapy has appeared to be a challenging issue for researchers and physicians. By the introduction of novel methods in immunotherapy, the prospect of cancer therapy even more explained than before. Cytokine‐induced killer (CIK) cell‐based immunotherapy demonstrated to have potentiality in improving clinical outcomes and ...
Solmaz Shirjang, Nazila Alizadeh, Behzad Mansoori, Ata Mahmoodpoor, Hossein Samadi Kafil, Mohammad Hojjat‐Farsangi, Mehdi Yousefi   +6 more
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Is there a Role for Cytokine-Induced Killer Cells in Cancer Immunotherapy?

Immunotherapy, 2012
867 ISSN 1750-743X 10.2217/IMT.12.89 © 2012 Future Medicine Ltd Immunotherapy (2012) 4(9), 867–869 “There is no doubt that the use of cytokine-induced killer cells holds promise but only the future will tell us whether this relatively simple form of adoptive cellular immunotherapy will really have an impact on the still dismal prognosis of patients ...
Rutella, Sergio, Locatelli, Franco
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The Therapeutic Potential of Cytokine-Induced Killer in Patients with Cancer

Journal of Interferon & Cytokine Research
Despite the promising results of immunotherapy, further experiments need to be considered because of several factors ranging from physical barriers to off-tumor adverse effects. It is surprising that adoptive cellular immunotherapy, particularly dendritic cell and cytokine-induced killer (DC-CIK) therapy, is far less emphasized in the treatment of ...
Sixun Zhong, Yan Zhang, Xiaomin Lu, Vafa Meftahpour   +3 more
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Cytokine Induced Killer (CIK) cells for the treatment of haematological neoplasms

Immunology Letters, 2013
Cytokine Induced Killer (CIK) cells are in vitro activated human CD8 T cells which have maintained several characteristics of T-EMRA cells and additionally acquired non specific anti tumoral cytotoxicity and CD56 overexpression, thus representing a cell population with double T and NK phenotype.
Martino Introna, Alessandro Rambaldi, Josée Golay   +2 more
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Progenitor-predominant exhaustion in cytokine-induced killers reveals TIM-3 as a superior target for enhancing cytokine-induced killer cytotoxicity

Journal of Leukocyte Biology
Abstract Precursor exhausted and terminally exhausted T cells (Tpex and Tex) are associated with immune checkpoints; T-cell checkpoint blockade may improve patient survival. We assessed cytotoxic activity and PD-1/TIM-3 expressions of CD3+CD8+CD56+ T cells (NK-like T) in cytokine-induced killer (CIK) cells across exhaustion states. We
Jian Wang, Qin Wang, Jiahui Zhou, Li Zhou, Xiubao Ren, Feng Wei   +5 more
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Clinical expansion of cytokine induced killer (CIK) cells

ISBT Science Series, 2012
Cytokine induced killer (CIK) cells are polyclonal T cells that can be expanded from marrow or peripheral blood lymphocytes with potent non‐MHC‐restricted cytotoxicity against a variety of tumor target cells. Earlier work had established the superiority of CIK cells over LAK cells in terms expansion and cytotoxicity.
M. B. C. Koh, Y. Ching Linn
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Ultrastructure of cytokine induced human natural killer cells

Cytotherapy, 2019
Background & Aim Natural Killer (NK) cells account for 3.66-26.74% of lymphocytes in the human peripheral blood. They secrete exosomes which express both NK-cell markers and cytokines. It has been shown that Interkin-2 (IL-2) stimulated the proliferation of natural killer cells, a sub-class of lymphocytes in human.
W. Ng, D. Tam, D. Liao, W. Lee, F. Chan
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Immunotherapy with Cytokine-Induced Killer Cells in Metastatic Renal Cell Carcinoma

Cancer Biotherapy and Radiopharmaceuticals, 2010
Cytokine-induced killer (CIK) cells have shown antitumor activity against several tumor cells both in vitro and in vivo. This study reports on the large-scale expansion of CIK cells and also present preliminary results from a pilot clinical trial.
Xiaosan, Su, Lei, Zhang, Liangkun, Jin, Junsong, Ye, Zheng, Guan, Rui, Chen, Tao, Guo   +6 more
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