Results 141 to 150 of about 2,261,376 (387)

Predictive survival modelings for HIV-related cryptococcosis: comparing machine learning approaches

Frontiers in Cellular and Infection Microbiology
IntroductionHIV-associated cryptococcosis is marked by unpredictable disease trajectories and persistently high mortality rates worldwide. Although improved risk stratification and tailored clinical management are urgently needed to enhance patient ...
Xuemin Fu, Luling Wu, Luling Wu, Jingna Xun, Benno Pütz, Zhihang Zheng, Yanpeng Li, Yanpeng Li, Yinzhong Shen, Hongzhou Lu, Jun Chen, Bertram Müller-Myhsok   +11 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Nodavirus increases the expression of Mx and inflammatory cytokines in fish brain [PDF]

, 2007
Laura Poisa-Beiro, S. Dios, Ariana Montes, Raquel Aranguren, António Figueras, Beatriz Novoa   +5 more
openalex   +1 more source

Effect and clinical mechanism exploration of acupuncture intervention for chemotherapy-related cognitive impairment (CRCI) in triple-negative breast cancer: study protocol for a randomized controlled trial

Frontiers in Neurology
BackgroundChemotherapy-Related Cognitive Impairment (CRCI) significantly impacts the quality of life of breast cancer patients. Triple-negative breast cancer (TNBC) is associated with a higher risk of cognitive decline.
Wenqi Yang, Wenqi Yang, Qing Zhang, Chong Gao, Jingzhi Zhang, Jingzhi Zhang, Xingwei Guo, Xingwei Guo, Xin Liu, Xin Liu   +9 more
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Roles of Inflammasome and Cytokines in the Pathogenesis of Autoimmune Thyroiditis

The Turkish Journal of Ear Nose and Throat
Objective: In this study, we aimed to investigate the role of the NLRP3 inflammasome, pro- and antiinflammatory cytokines, and their correlations in the pathogenesis of HT. Material and Methods: The pro-inflammatory cytokine tumour necrosis factor alpha (
Gülten Ateş, İsmail Cem Sormaz
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Arginine-Glycine-Aspartic Acid-anchored Curcumin-based NanotherapeuticsInhibit Pyroptosis-induced Cytokine Release Syndrome for In Vivo and In VitroSepsis Applications

, 2023
Xiaoling Xu, Wei Chen, Yi Shi, Qian Wu, Yi Lu, Lingpeng Meng, Xiaojuan Wang   +6 more
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source