Results 131 to 140 of about 1,857,465 (364)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

HIV TAT modulation of IFN-γ-induced expression of autophagy-associated genes in primary human blood macrophages

, 2009
Human immunodeficiency virus (HIV), the causative agent of AIDS, continues to be a major cause of morbidity and mortality worldwide. Immune defects in HIV patients are closely associated with intense cytokine dysregulation.
Au, KY, Fang, JW, Li, JCB, Lau, ASY, Yim, HCH   +4 more
core   +1 more source

Tetrahydrobiopterin and Cytokines

Experimental Biology and Medicine, 1993
Biosynthesis of tetrahydrobiopterin starts from guanosine triphosphate by the action of guanosine triphosphate cyclohydrolase I, which yields the first intermediate, 7,8-dihydroneopterin triphosphate. This compound is then converted by subsequent enzymes, 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase, to tetrahydrobiopterin, the ...
E R, Werner, G, Werner-Felmayer, H, Wachter   +2 more
openaire   +2 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - Redundancy or specificity of neuroimmunoendocrine modulators? [PDF]

, 2004
Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM.
Kopp, F. B., Isele, N. B., Cengic, N., Weber, M. M., Engelhardt, D., Spottl, G., Senaldi, G., Auernhammer, Christoph J., Dorn, F., Vlotides, G.   +9 more
core   +1 more source

Bacterial peptidoglycan levels have brain area, time of day, and sleep loss-induced fluctuations

Frontiers in Neuroscience
Sleep-inducing bacterial cell wall components isolated from brain and urine of sleep deprived animals were identified as peptidoglycan (PG) and muropeptides in the 1980s.
Erika L. English, James M. Krueger
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Th1/Th2 cytokine profile in childhood-onset systemic lupus erythematosus

, 2015
Objective: To determine the serum levels of Th1 (IL-12, IFN-gamma,TNF-alpha) and Th2 (IL-5, IL-6 and IL-10) cytokines in childhood-onset SLE, first-degree relatives and healthy controls.
Marini, R, Postal, M, Appenzeller, S, Sinicato, NA, Costallat, LTL, Pelicari, KO   +5 more
core   +1 more source

Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study. [PDF]

, 2011
BACKGROUND: Chronic soil-transmitted helminth (STH) infections are associated with effects on systemic immune responses that could be caused by alterations in immune homeostasis.
Cooper, Philip J, Broncano, N, Reina Ortiz, Miguel, Miguel Reina Ortiz, Schreiber Fernanda, David J Lewis, Alexander Neal, Lewis, David J, Chico, ME, Benitez Susana, David J. Lewis, Vaca Maritza, Nely Broncano, Chico, Martha E, Dougan Gordon, Reina Ortiz, M, Fernanda Schreiber, Martha E. Chico, Schreiber, F, Alexander, N, Lewis, DJ, Philip J. Cooper, Gordon Dougan, Cooper Philip J., Dougan, Gordon, Neal Alexander, Vaca, Maritza, Benitez, S, Vaca, M, Martha E Chico, Benitez, Susana, Philip J Cooper, Broncano Nely, Alexander, Neal, Maritza Vaca, Susana Benitez, Dougan, G, Lewis David J., Schreiber, Fernanda, Cooper, PJ, Reina Ortiz Miguel, Cooper, Philip, Broncano, Nely, Chico Martha E.   +43 more
core   +1 more source

Coxsackie B1 virus-like particle vaccine modified to exclude a highly conserved immunoreactive region from the capsid induces potent neutralizing antibodies and protects against infection in mice

Journal of Biomedical Science
Background Enteroviruses, including Coxsackie B (CVB) viruses, can cause severe diseases such as myocarditis, pancreatitis, and meningitis. Vaccines can prevent these complications, but conserved non-neutralizing epitopes in the viral capsid may limit ...
Saana Soppela, Martín González-Rodríguez, Virginia M. Stone, Iiris Mustonen, Niila V. V. Jouppila, Vili Lampinen, Teemu Haikarainen, Malin Flodström-Tullberg, Ilkka S. Junttila, Minna M. Hankaniemi   +9 more
doaj   +1 more source