Results 141 to 150 of about 1,857,465 (364)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Cytokine profiles of chronic fatigue syndrome and multiple sclerosis patients.

, 2014
Aims Chronic Fatigue Syndrome (CFS) and Multiple Sclerosis (MS) are both disorders with severe neuroimmune symptoms, including cognitive impairment, immune dysfunction and abnormal cytokine expression. The purpose of this study was to assess the T helper
Broadley, Simon, Hawthorn, Ally, Wong, Naomi, Hardcastle, Sharni Lee, Ramos, Sandra, Nguyen, Thao, Huth, Teilah Kathryn, Passmore, Rachel, Salajegheh, Ali, Staines, Don, Huth, Teilah, Thao, Nguyen, Marshall-Gradisnik, Sonya, Johnston, Samantha, Ramos, Sandra Bahia, Brenu, Ekua, Hardcastle, Sharni   +16 more
core   +1 more source

Peripheral blood inflammatory score using a cytokine multiplex assay predicts clinical outcomes in patients treated with atezolizumab-bevacizumab for unresectable HCC

Frontiers in Immunology
BackgroundSeveral serum cytokines have been proposed as biomarkers for predicting the outcomes of patients with hepatocellular carcinoma (HCC) receiving tyrosine kinase inhibitors. However, their role in atezolizumab plus bevacizumab (AB) treatment needs
Hee Sun Cho, Hee Sun Cho, Hee Sun Cho, Soon Kyu Lee, Soon Kyu Lee, Ji Won Han, Ji Won Han, Jung Hyun Kwon, Jung Hyun Kwon, Soon Woo Nam, Soon Woo Nam, Jaejun Lee, Jaejun Lee, Keungmo Yang, Keungmo Yang, Pil Soo Sung, Pil Soo Sung, Jeong Won Jang, Jeong Won Jang, Seung Kew Yoon, Seung Kew Yoon, Jong Young Choi, Jong Young Choi   +22 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Influence of oxidative stress, diaphragm fatigue and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation

, 2014
The influence of oxidative stress, diaphragm fatigue and inspiratory muscle training (IMT) on the cytokine response to maximum sustainable voluntary ventilation (MSVV) is unknown.
Gonzalez, JT, Neil C. Williams (16672905), Mills, Dean E., Martin J. McPhilimey (16672902), Gonzalez, Javier T., Gonzalez, J.T., Neil C. Williams, Sharpe, GR, Sharpe, Graham R., McPhilimey, Martin J., Williams, NC, Graham R. Sharpe (16661214), Sharpe, G.R., Mills, Dean, Gonzalez, Javier, McPhilimey, Martin, McPhilimey, MJ, McPhilimey, M.J., Johnson, Michael A., Yvonne A. Barnett, Dean E. Mills (16661205), Yvonne A. Barnett (16661208), Graham R. Sharpe, Barnett, YA, Martin J. McPhilimey, Mills, DE, Javier T. Gonzalez (8473264), Barnett, Yvonne, Javier T. Gonzalez, Johnson, M.A., Sharpe, Graham, Williams, N.C., Williams, Neil C., Dean E. Mills, Johnson, MA, Mills, D.E., Barnett, Yvonne A., Barnett, Y.A., Michael A. Johnson, Michael A. Johnson (1317849), Williams, Neil   +40 more
core   +1 more source

Predictive survival modelings for HIV-related cryptococcosis: comparing machine learning approaches

Frontiers in Cellular and Infection Microbiology
IntroductionHIV-associated cryptococcosis is marked by unpredictable disease trajectories and persistently high mortality rates worldwide. Although improved risk stratification and tailored clinical management are urgently needed to enhance patient ...
Xuemin Fu, Luling Wu, Luling Wu, Jingna Xun, Benno Pütz, Zhihang Zheng, Yanpeng Li, Yanpeng Li, Yinzhong Shen, Hongzhou Lu, Jun Chen, Bertram Müller-Myhsok   +11 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Effect and clinical mechanism exploration of acupuncture intervention for chemotherapy-related cognitive impairment (CRCI) in triple-negative breast cancer: study protocol for a randomized controlled trial

Frontiers in Neurology
BackgroundChemotherapy-Related Cognitive Impairment (CRCI) significantly impacts the quality of life of breast cancer patients. Triple-negative breast cancer (TNBC) is associated with a higher risk of cognitive decline.
Wenqi Yang, Wenqi Yang, Qing Zhang, Chong Gao, Jingzhi Zhang, Jingzhi Zhang, Xingwei Guo, Xingwei Guo, Xin Liu, Xin Liu   +9 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source