Results 181 to 190 of about 2,225,287 (343)
Arthritis Care &Research, Accepted Article.Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti +19 more
wiley +1 more source
Evidence for the Involvement of Spinal Cord-Inhibitory and Cytokines-Modulatory Mechanisms in the Anti-Hyperalgesic Effect of Hecogenin Acetate, a Steroidal Sapogenin-Acetylated, in Mice [PDF]
, 2014 Jullyana de Souza Siqueira Quintans +11 more
openalex +1 more source
Beyond Inflammation: Why Understanding the Brain Matters in Inflammatory Arthritis
Arthritis Care &Research, EarlyView.Persistent pain remains a major challenge in inflammatory arthritis, even when joint inflammation is well controlled. Pain and associated symptoms such as fatigue cannot be explained by peripheral inflammation alone but reflect altered central pain processing. These changes may arise through “top‐down” mechanisms, reflecting pre‐existing dysfunction in
Eoin M. Kelleher +2 more
wiley +1 more source
Integration of T‐cell receptor, Notch and cytokine signals programs mouse γδ T‐cell effector differentiation [PDF]
, 2018 Payam Zarin +8 more
openalex +1 more source
The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization
Advanced Biology, EarlyView.This study explores the use of collagen‐hyaluronic acid (HA) hydrogels for the 3D culture of macrophages, providing a useful tool for modelling macrophage behavior in tissues and diseases. It highlights how hydrogel composition, mechanical properties, and preparation methods influence macrophage behavior, revealing for the first time that HA's ...
Tiah CL Oates +7 more
wiley +1 more source
Lung Microphysiological System Validates Novel Cell Therapy for Acute Respiratory Distress Syndrome
Advanced Biology, EarlyView.This study aims to evaluate the efficacy of primed mesenchymal stem cells (pMSCs) as an alternative treatment for Acute Respiratory Distress Syndrome (ARDS), based on a novel lung microphysiological system (MPS) to test the efficacy of pMSCs over the standard treatment, Dexamethasone.
Bokyong Kim +11 more
wiley +1 more source
Amide Analogues of CD1d Agonists Modulate iNKT-Cell-Mediated Cytokine Production [PDF]
, 2012 Justyna Wojno +6 more
openalex +1 more source
Advanced Biology, EarlyView.The article explores the discovery of unusually large, ring‐shaped ESCRT protein structures formed by immune and stromal cells. It investigates their formation, composition, and potential roles in immune synapse formation. The findings challenge assumptions about their function in immunological synapses, suggesting an exclusive role in maintaining ...
Anthi Psoma +3 more
wiley +1 more source
Advanced Biology, EarlyView.This study investigates the photosensitizing potential of Passiflora cincinnata in Antimicrobial Photodynamic Therapy (aPDT) against skin infection caused by Methicillin‐resistant Staphylococcus aureus (MRSA) in a senescent murine model. The P. cincinnata exhibits antimicrobial activity, with reduced bacterial load, lower leukocyte infiltration, and ...
Caroline Vieira Gonçalves +14 more
wiley +1 more source