Results 191 to 200 of about 1,176,895 (316)

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Orthobiologics are not all the same: a mechanism-based scoping review of PRP, cytokine-rich serum, and extracellular vesicle-based strategies in musculoskeletal conditions. [PDF]

Front Pain Res (Lausanne)
Di Lorenzo L, Forte AM, De Meo B, Forte F, D'Avanzo C, Zmerly H.   +5 more
europepmc   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

Comparative Immunopathology of Toxoplasma gondii Natural Infections in Marmosets (Callithrix spp.) and Howler Monkeys (Alouatta spp.), Brazil. [PDF]

J Med Primatol
Pellegrino M, Santos ALM, Dos Santos Cirqueira C, da Silva Gagliotti GFP, Ewbank AC, Sacristán C, Ressio RA, Fernandes NCCA, Guerra JM, Catão-Dias JL.   +9 more
europepmc   +1 more source

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Revisiting CD8⁺ T Cells in Allergy: The Emerging Role of Tc2 Cells. [PDF]

Scand J Immunol
de Souza Ferreira S, Tibbitt CA.
europepmc   +1 more source

A Novel Drug‐Loaded Porous Parylene Electrode for Targeted Anti‐Inflammatory Therapy and Hearing Preservation in Cochlear Implantation

Advanced Healthcare Materials, EarlyView.
A porous parylene‐coated electrode loaded with dexamethasone was developed to reduce inflammation after cochlear implantation. In guinea pigs, the device provided sustained drug release, maintained biocompatibility, improved auditory brainstem response thresholds, and reduced inflammatory cell infiltration and TNF‐α expression.
Chi‐Chieh Chang, Ying‐Chang Lu, Yu‐Ming Chang, Yen‐Hui Chan, Hong‐Yu Yan, Yi‐Shan Lee, Pei‐Hsuan Lin, Cheng‐Yu Hsieh, Chuan‐Jen Hsu, Tien‐Chen Liu, Hsien‐Yeh Chen, Chen‐Chi Wu   +11 more
wiley   +1 more source

A Microglia-Astrocyte Signaling Axis Regulates Astrocyte Piezo1 Expression and Inflammatory Responses. [PDF]

Glia
Bai Y, Choi HB, Wendt S, Towriss M, Lin AJ, Groten CJ, Cui I, Nygaard HB, MacVicar BA.   +8 more
europepmc   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Early Identification of a Cytokine-Low Immune Phenotype in Suspected Sepsis Using a Point-of-Care Whole-Blood TNF-α Release Assay. [PDF]

Med Sci (Basel)
Plata-Menchaca EP, Cisteró B, Ceccato A, Monforte V, Caus-Capdevila Q, Areny-Balaguero A, Campaña-Duel E, Camprubí-Rimblas M, Goma-Fernandez G, Guijarro C, Salom P, Lopez M, Tajan J, Teles De Castro T, Roman V, Vieyra J, Cubedo J, Guerrero E, Gené E, Artigas A, Hernández-Jiménez E.   +20 more
europepmc   +1 more source