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Cytokines, antibodies to cytokines and autoimmunity

Drugs of Today, 1998
It is commonly accepted that cytokines play a major role in the generation of immune responses to various stimuli, whether to exogenous antigens or to autoimmune events. This process must be regulated via complex mechanisms that maintain the normal immune homeostasis. Anti-cytokine antibodies (ACAs) are one of the components that take part in confining
Amital H, Shoenfeld Y
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Cytokine–cytokine interactions and the brain

Brain Research Bulletin, 2000
Cytokine-cytokine interactions play a role in health and are crucial during immunological and inflammatory responses in disease. Cytokine interactions can result in additive, antagonist, or synergistic activities in maintaining physiological functions such as feeding, body temperature, and sleep, as well as in anorectic, pyrogenic, and somnogenic ...
Nicolas P. Turrin   +1 more
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Cytokines and anti-cytokines

Current Opinion in Immunology, 1989
Cytokines manifest multiple biological activities in different target cells, and many cytokines are produced by a variety of cell types in response to different stimuli. Furthermore, the expression of a given cytokine gene is invariably influenced by other cytokines, forming a network of ‘cytokine cascades’.
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Inhibitory cytokines and cytokine inhibitors

Neurology, 1995
Cytokines such as interleukin-1 and tumor necrosis factor are involved in the triggering of the immune response, induction of acute inflammatory events, and transition to, or persistence of, chronic inflammation. The action of proinflammatory cytokines is regulated by their receptor expression, downregulation and shedding, by specific inhibitors, and ...
Jean-Michel Dayer, Danielle Burger
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Is a "Cytokine Storm" Relevant to COVID-19?

JAMA Internal Medicine, 2020
In its most severe form, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), leads to a life-threatening pneumonia and acute respiratory distress syndrome (ARDS).
P. Sinha, M. Matthay, C. Calfee
semanticscholar   +1 more source

Cytokines

The Biomedical & Life Sciences Collection, 2009
Abstract 74Cytokines are small glycoprotein mediators that are involved in every facet of immune effector function and regulation, and moreover serve to integrate immune function with other physiologic processes (e.g. metabolism, neurologic function). More than 200 cytokines have been identified. Understanding of the cytokine network has
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Interleukin-6: A Masterplayer in the Cytokine Network

Oncology, 2020
Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans.
P. Uciechowski, W. Dempke
semanticscholar   +1 more source

Cytokines and natural regulators of cytokines

Immunology Letters, 1994
Cytokines are polypeptide or glycopeptide signalling molecules with molecular weights from 5 to 70,000 Daltons (Table 1). They act at extremely low concentrations (picomolar and femtomolar levels) as essential mediators of infectious and immunoinflammatory reactions.
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Inhaled cytokines and cytokine antagonists

Advanced Drug Delivery Reviews, 2006
Cytokine and cytokine antagonist have provided novel and effective therapies for many human diseases. A number of approved cytokines including the interferons (alpha, beta and gamma), interleukin-2 (IL-2), granulocyte macrophage colony stimulating factor (GM-CSF) as well as novel cytokine antagonists have been administered by the pulmonary route for ...
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Cytokines in Cytokine Storm Syndrome

2019
As the eponymous mediators of the cytokine storm syndrome, cytokines are a pleomorphic and diverse set of soluble molecules that activate or suppress immune functions in a wide variety of ways. The relevant cytokines for each CSS are likely a result of differing combinations of environmental triggers and host susceptibilities.
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