Results 231 to 240 of about 5,332,469 (256)

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Barriers and Blueprints: Next-Generation Engineering Strategies for CAR-T Cell Therapy in Gastrointestinal Tumors. [PDF]

Pharmaceuticals (Basel)
Ismail M, Al-Gizey N, Alabed Z, Mustafa N, Al-Najjar E, Hamdaneh Y, Eid N, Esmail A.   +7 more
europepmc   +1 more source

Engineering CAR-T cells for solid tumors: Overcoming the microenvironment through integrated design and clinical translation. [PDF]

Oncoscience
Onyekweli SO, Omoruyi GO, Akintayo CO, Olaniyi SK.   +3 more
europepmc   +1 more source

Integrated Engineering of CAR-T Cells for Solid Tumours. [PDF]

Cell Prolif
Yang C, Li T, He P, Zhao Z, Li S, Wang L.   +5 more
europepmc   +1 more source

Adoptive T Cell therapy for cancer and autoimmune disease: current advances, challenges, and future directions. [PDF]

Oncol Rev
Bao QH, Wu A, Pang J, Wang J, Chen Q, Wu S.   +5 more
europepmc   +1 more source

Engineering cytokine therapeutics [PDF]

Nature Reviews Bioengineering, 2023
Cytokines have pivotal roles in immunity, making them attractive as therapeutics for a variety of immune-related disorders. However, the widespread clinical use of cytokines has been limited by their short blood half-lives and severe side effects caused ...
Leo A.B. Joosten, Anne de Dreu, Jamie Spangler   +2 more
exaly   +2 more sources

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Recent and future perspectives on engineering interferons and other cytokines as therapeutics

Trends in Biochemical Sciences, 2023
Juan Mendoza
exaly