Results 71 to 80 of about 5,332,469 (256)

Design Catalogues: An Efficient Search Approach for Improved Flexibility in Engineering Systems Design [PDF]

, 2013
23rd Annual International Symposium of the International Council on Systems Engineering, INCOSE 20131398 ...
Cardin, Michel-Alexandre, de Neufville, Richard, Richard de Neufville, Michel‐Alexandre Cardin   +3 more
core   +1 more source

Analysis of the Pro- and Anti-Inflammatory Cytokines Secreted by Adult Stem Cells during Differentiation

Stem Cells International, 2015
Adipose-derived stromal/stem cells (ASCs) are adult stem cells that have the potential to differentiate into mesenchymal lineage cells. The abundance of ASCs in adipose tissue and easy accessibility with relatively little donor site morbidity make them ...
Amy L. Strong, Jeffrey M. Gimble, Bruce A. Bunnell   +2 more
doaj   +1 more source

Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions

Frontiers in Immunology, 2017
The activity of tumor necrosis factor (TNF), a cytokine involved in inflammatory pathologies, can be inhibited by antibodies or trap molecules. Herein, llama-derived variable heavy-chain domains of heavy-chain antibody (VHH, also called Nanobodies™) were
Els Beirnaert, Aline Desmyter, Aline Desmyter, Silvia Spinelli, Silvia Spinelli, Marc Lauwereys, Lucien Aarden, Torsten Dreier, Remy Loris, Remy Loris, Karen Silence, Caroline Pollet, Christian Cambillau, Christian Cambillau, Hans de Haard   +14 more
doaj   +1 more source

Cytokine release syndrome and neurologic toxicities associated with chimeric antigen receptor T-cell therapy: A comprehensive review of emerging grading models

Hematology/Oncology and Stem Cell Therapy, 2020
Advances in the fields of immuno-oncology and T-cell engineering have brought autologous chimeric antigen receptor T-cell (CART) therapies from the bench to the bedside.
Julio C. Chavez, Michael D. Jain, Mohamed A. Kharfan-Dabaja   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A combinational approach to restore cytokine balance and to inhibit virus growth may promote patient recovery in severe COVID-19 cases

, 2020
The COVID-19 pandemic has led to twin public health and economic crises around the world. Not only has it cost hundreds of thousands of lives but also severely impacted livelihoods and placed enormous strain on community healthcare and welfare services ...
Mahmud-Al-Rafat, Abdullah, Muktadir, Hasneen, Billah, Morsaline, Muktadir, Abdul, Khan, Imran, Karim, Mahbubul, Haque Asim, Muzammal, Majumder, Apurba, Taylor-Robinson, Andrew W., Mainul Ahasan, Mohammad   +9 more
core   +1 more source

Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells [PDF]

, 2000
Copyright @ 2000 The Rockefeller University Press. This article is shared under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons ...
Sjögren, HO, Paulsson, KM, Anette Sundstedt, Xu, X., Chen, S, Xiufeng Xu, Chen, Shangwu, Sundstedt, Anette, Karlsson, Stefan, Hans-Olov Sjögren, Karlsson, S, Li, Suling, Paulsson, Kajsa, Wang, P, Kajsa M. Paulsson, Sjögren, Hans Olov, Suling Li, Sundstedt, A, Stefan Karlsson, Xu, X, Anderson, P, Ping Wang, Wang, Ping, Shangwu Chen, Per Anderson, andersson, Per, andersson, Per,, Karlsson, Stefan,, Chen, Shangwu,, Li, Suling,, Paulsson, Kajsa,, Xu, X.,, Sjögren, Hans Olov,, Wang, Ping,, Sundstedt, Anette,, Lund University.   +35 more
core   +1 more source

Redirecting immune signaling with cytokine adaptors

Nature Communications
Cytokines are signaling molecules that coordinate complex immune processes and are frequently dysregulated in disease. While cytokine blockade has become a common therapeutic modality, cytokine agonism has had limited utility due to the widespread ...
Gita C. Abhiraman, Karsten D. Householder, Grayson E. Rodriguez, Caleb R. Glassman, Robert A. Saxton, Cort B. Breuer, Steven C. Wilson, Leon Su, Michelle Yen, Cynthia Hsu, Venu G. Pillarisetty, Nathan E. Reticker-Flynn, K. Christopher Garcia   +12 more
doaj   +1 more source

eVLP-mediated CREM editing enhances cytotoxicity of bicistronic IL-15-armored CD19/BCMA dual-target CAR-NK cells

Frontiers in Immunology
Chimeric antigen receptor (CAR)-engineered natural killer (NK) cells represent a promising platform for cancer immunotherapy; however, optimization of CAR architecture and additional engineering strategies remain necessary to improve their functional ...
Fengqin Shang, Guanlie Li, Shiting Gong, Lijiao Zhao, Bingyu Niu, Hanyi Chen, Yuchen Fu, Lijun Zhao, Jianxun Wang, Yuanyuan Shi   +9 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source