Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation. [PDF]
Science, 2022 Cytokines signal through cell surface receptor dimers to initiate activation of intracellular Janus kinases (JAKs). We report the 3.6-angstrom–resolution cryo–electron microscopy structure of full-length JAK1 complexed with a cytokine receptor ...
Glassman CR +5 more
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Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins. [PDF]
Nat Biotechnol, 2023 Targeted degradation of cell surface and extracellular proteins via lysosomal delivery is an important means to modulate extracellular biology. However, these approaches have limitations due to lack of modularity, ease of development, restricted tissue ...
Pance K +7 more
europepmc +2 more sources
The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor [PDF]
Frontiers in Molecular Neuroscience, 2023 The evolutionary conserved orphan cytokine receptor-like factor 3 (CRLF3) has been implicated in human disease, vertebrate hematopoiesis and insect neuroprotection.
Debbra Y. Knorr +10 more
doaj +2 more sources
Cytokine Receptor-Like Factor 3 (CRLF3) Contributes to Early Zebrafish Hematopoiesis [PDF]
Frontiers in Immunology, 2022 Cytokine receptor-like factor 3 (CRLF3) is an ancient protein conserved across metazoans that contains an archetypal cytokine receptor homology domain (CHD).
Tarannum Taznin +6 more
doaj +2 more sources
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. [PDF]
Science, 2020 Activated by interaction Cytokines trigger immune responses when they bind to their cognate receptors. Class I cytokine receptors rely on the associated Janus kinase 2 (JAK2) to initiate signal transduction.
Wilmes S +17 more
europepmc +2 more sources
In Situ Identification of Both IL-4 and IL-10 Cytokine–Receptor Interactions during Tissue Regeneration [PDF]
Cells, 2023 Cytokines secreted by individual immune cells regulate tissue regeneration and allow communication between various cell types. Cytokines bind to cognate receptors and trigger the healing process.
Krisztina Nikovics +6 more
doaj +2 more sources
Frontiers in Molecular Neuroscience, 2017 The cytokine erythropoietin (Epo) mediates various cell homeostatic responses to environmental challenges and pathological insults. While stimulation of vertebrate erythrocyte production is mediated by homodimeric “classical” Epo receptors, alternative ...
Nina Hahn +10 more
doaj +2 more sources
Kinetics of cytokine receptor trafficking determine signaling and functional selectivity. [PDF]
Elife, 2019 Cytokines activate downstream signaling networks via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes.
Martinez-Fabregas J +12 more
europepmc +2 more sources
Cytokine-Leukotriene Receptor Interactions [PDF]
The Scientific World Journal, 2007 Biochemical and pharmacological studies have identified the structure of leukotrienes, the pathways that lead to their synthesis, and the signaling events they trigger when they interact with their cognate receptors.
Marek Rola-Pleszczynski, Jana Stankova
doaj +4 more sources
Scientific Reports, 2021 Type I Interferon (IFN) was the very first drug approved for the treatment of Multiple Sclerosis (MS), and is still frequently used as a first line therapy. However, systemic IFN also causes considerable side effects, affecting therapy adherence and dose
Anje Cauwels +9 more
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