Results 1 to 10 of about 3,715,994 (387)

The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor [PDF]

Frontiers in Molecular Neuroscience, 2023
The evolutionary conserved orphan cytokine receptor-like factor 3 (CRLF3) has been implicated in human disease, vertebrate hematopoiesis and insect neuroprotection.
Debbra Y. Knorr, Ignacio Rodriguez Polo, Ignacio Rodriguez Polo, Ignacio Rodriguez Polo, Ignacio Rodriguez Polo, Hanna S. Pies, Nicola Schwedhelm-Domeyer, Stephanie Pauls, Rüdiger Behr, Rüdiger Behr, Ralf Heinrich   +10 more
doaj   +2 more sources

Cytokine Receptor-Like Factor 3 (CRLF3) Contributes to Early Zebrafish Hematopoiesis [PDF]

Frontiers in Immunology, 2022
Cytokine receptor-like factor 3 (CRLF3) is an ancient protein conserved across metazoans that contains an archetypal cytokine receptor homology domain (CHD).
Tarannum Taznin, Kaushalya Perera, Yann Gibert, Alister C. Ward, Alister C. Ward, Clifford Liongue, Clifford Liongue   +6 more
doaj   +2 more sources

In Situ Identification of Both IL-4 and IL-10 Cytokine–Receptor Interactions during Tissue Regeneration [PDF]

Cells, 2023
Cytokines secreted by individual immune cells regulate tissue regeneration and allow communication between various cell types. Cytokines bind to cognate receptors and trigger the healing process.
Krisztina Nikovics, Anne-Laure Favier, Mathilde Rocher, Céline Mayinga, Johanna Gomez, Frédérique Dufour-Gaume, Diane Riccobono   +6 more
doaj   +2 more sources

Mapping Determinants of Cytokine Signaling via Protein Engineering [PDF]

Frontiers in Immunology, 2018
Cytokines comprise a large family of secreted ligands that are critical for the regulation of immune homeostasis. Cytokines initiate signaling via dimerization or oligomerization of the cognate receptor subunits, triggering the activation of the Janus ...
Claire Gorby, Jonathan Martinez-Fabregas, Stephan Wilmes, Ignacio Moraga   +3 more
doaj   +5 more sources

Cytokine-Leukotriene Receptor Interactions [PDF]

The Scientific World Journal, 2007
Biochemical and pharmacological studies have identified the structure of leukotrienes, the pathways that lead to their synthesis, and the signaling events they trigger when they interact with their cognate receptors.
Marek Rola-Pleszczynski, Jana Stankova
doaj   +3 more sources

Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells. [PDF]

Cell Rep Med
Yoshikawa T, Ito Y, Wu Z, Kasuya H, Nakashima T, Okamoto S, Amaishi Y, Zhang H, Li Y, Matsukawa T, Inoue S, Kagoya Y.   +11 more
europepmc   +2 more sources

Cytokine-Cytokine Receptor Interaction and Endocytosis are Common Pathways for Symptom Burden and Sickness Behavior Symptoms in Oncology Patients Undergoing Chemotherapy. [PDF]

Cancer Med
Harris CS, Kober KM, Shin J, Morse L, Oppegaard KR, Paul S, Hammer MJ, Levine JD, Conley YP, Miaskowski CA.   +9 more
europepmc   +3 more sources

Targeting IFN activity to both B cells and plasmacytoid dendritic cells induces a robust tolerogenic response and protection against EAE

Scientific Reports, 2021
Type I Interferon (IFN) was the very first drug approved for the treatment of Multiple Sclerosis (MS), and is still frequently used as a first line therapy. However, systemic IFN also causes considerable side effects, affecting therapy adherence and dose
Anje Cauwels, Sandra Van Lint, Elke Rogge, Annick Verhee, Bram Van Den Eeckhout, Shengru Pang, Marco Prinz, Niko Kley, Gilles Uzé, Jan Tavernier   +9 more
doaj   +1 more source

Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]

, 2013
Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Mühl, Heiko
core   +9 more sources

Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

eLife, 2023
Dimerization of the thrombopoietin receptor (TpoR) is necessary for receptor activation and downstream signaling through activated Janus kinase 2. We have shown previously that different orientations of the transmembrane (TM) helices within a receptor ...
Jean-Philippe Defour, Emilie Leroy, Sharmila Dass, Thomas Balligand, Gabriel Levy, Ian C Brett, Nicolas Papadopoulos, Céline Mouton, Lidvine Genet, Christian Pecquet, Judith Staerk, Steven O Smith, Stefan N Constantinescu   +12 more
doaj   +1 more source