Pancreas in recent onset insulin-dependent diabetes mellitus: changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor Vbeta usage and cytokine profile [PDF]
, 1994 N Somoza +10 more
openalex +1 more source
Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies
Aging and Cancer, EarlyView.This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal +8 more
wiley +1 more source
Cytokine Receptor Allele Frequency, Immunogenicity, and Efficacy of New COVID-19 Vaccine in Different Setting. [PDF]
Int J Prev Med, 2023 Joob B, Wiwanitkit V.
europepmc +1 more source
Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. [PDF]
, 1996 The killer cell inhibitory receptors (KIRs) are surface glycoproteins expressed by natural killer (NK) and T cells that specifically recognize defined groups of polymorphic human histocompatibility leukocyte antigen (HLA) class I molecules.
Chang, C +3 more
core
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
Science, 2018 Jonathan T. Sockolosky +17 more
semanticscholar +1 more source
Aging and Cancer, EarlyView.Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley +1 more source
A strategy to design protein-based antagonists against type I cytokine receptors.
PLoS BiologyExcessive cytokine signaling resulting from dysregulation of a cytokine or its receptor can be a main driver of cancer, autoimmune, or hematopoietic disorders.
Timo Ullrich +12 more
doaj +1 more source
Goose Hepatic IGFBP2 Is Regulated by Nutritional Status and Participates in Energy Metabolism Mainly through the Cytokine-Cytokine Receptor Pathway. [PDF]
Animals (Basel), 2023 Li F +8 more
europepmc +1 more source
Cytokine and Cytokine Receptor Pleiotropy and Redundancy [PDF]
Journal of Biological Chemistry, 2002 Warren J. Leonard, Katsutoshi Ozaki
openaire +2 more sources
Nature CommunicationsThrombopoietin (Tpo) is the primary regulator of megakaryocyte and platelet numbers and is required for haematopoetic stem cell maintenance. Tpo functions by binding its receptor (TpoR, a homodimeric Class I cytokine receptor) and initiating cell ...
Kaiseal T. G. Sarson-Lawrence +13 more
doaj +1 more source