Results 131 to 140 of about 193,929 (276)

Cytokine release syndrome-like serum responses after COVID-19 vaccination are frequent and clinically inapparent under cancer immunotherapy [PDF]

, 2022
Thomas Walle, Sunanjay Bajaj, Joscha A. Kraske, Thomas Rösner, Christiane S. Cussigh, Katharina A. Kälber, Lisa Müller, S Strobel, Jana Burghaus, Stefan M. Kallenberger, Christoph Stein-Thöringer, Maximilian Jenzer, Antonia Schubert, Steffen Kahle, Anja Williams, Birgit Hoyler, Lin Zielske, Renate Skatula, Stefanie Sawall, Mathias F. Leber, Russell Kunes, Johannes Krisam, Carlo Fremd, Andreas Schneeweiß, Jürgen Krauß, Leonidas Apostolidis, Anne Berger, Georg Martin Haag, Stefanie Zschäbitz, Niels Halama, Christoph Springfeld, Romy Kirsten, Jessica C. Hassel, Dirk Jäger, Christiane S. Cussigh, Katharina A. Kälber, Omar Abdelrahim, Elena Busch, Patrick Derigs, Katharina Dischinger, Fouad Mitri, Kerstin Schmidt, Irfan A. Bhatti, Barbara Grün, Nicolas Hohmann, Lena Woydack, Xinwen Zhang, Dyke Ferber, Andreas Möck, Tillmann Pompecki, Timo Schank, Carlo Fremd, Georg Martin Haag, Niels Halama, Romy Kirsten, Jessica C. Hassel, Dirk Jäger, Guy Ungerechts, Guy Ungerechts   +58 more
openalex   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Tocilizumab Use in Children with Cytokine Release Syndrome

Indian Pediatrics, 2021
Revathi, Raj, Ramya, Uppuluri, V S, Venkateswaran   +2 more
openaire   +2 more sources

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source

Severe cytokine release syndrome induced by immune checkpoint inhibitors in cancer patients – A case report and review of the literature [PDF]

Y Zhang, Xiaoyue Wen, Yaqi Ouyang, Yingying Hu, Xiangzhi Fang, Jiancheng Zhang, Yuan Yin   +6 more
openalex   +1 more source

Figure S4 from Tumor Microenvironment Composition and Severe Cytokine Release Syndrome (CRS) Influence Toxicity in Patients with Large B-Cell Lymphoma Treated with Axicabtagene Ciloleucel

, 2023
Rawan Faramand, Michael D. Jain, Verena Staedtke, Hiroshi Kotani, Ren-Yuan Bai, Kayla Reid, Sae Bom Lee, Kristen Spitler, Xuefeng Wang, Biwei Cao, Javier Pinilla, Aleksander Lazaryan, Farhad Khimani, Bijal Shah, Julio C. Chávez, Taiga Nishihori, Asmita Mishra, John E. Mullinax, Ricardo González, Mohammad Hussaini, Marian Dam, Brigett D. Brandjes, Christina A. Bachmeier, Claudio Anasetti, Frederick L. Locke, Marco L. Davila   +25 more
openalex   +1 more source

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Tocilizumab for the treatment of chimeric antigen receptor T cell-induced cytokine release syndrome

, 2019
Chelsea Kotch, David M. Barrett, David T. Teachey   +2 more
openalex   +2 more sources

Decreased serum phosphate levels are a useful biomarker to predict occurrence and severity of cytokine release syndrome in chimeric antigen receptor T‐cell therapy

, 2022
Naokazu Nakamura, Yasuyuki Arai, Toshio Heike, Tomoyasu Jo, Chisaki Mizumoto, Junya Kanda, Momoko Nishikori, Kouhei Yamashita, Akifumi Takaori‐Kondo   +8 more
openalex   +1 more source