Results 71 to 80 of about 2,857,482 (280)

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Cytokine release syndrome after chimeric antigen receptor T cell therapy in patients with diffuse large B-cell lymphoma: a systematic review

Hematology, Transfusion and Cell Therapy
Introduction: Chimeric antigen receptor T (CAR-T) cell therapy is an innovative technology that has shown promising results in clinical trials. Treatment is based on modifying the patient's own T cells to express artificial surface receptors to ...
Andressa Rodrigues dos Santos, Daniela Zanini, Daniel Andolfatto   +2 more
doaj   +1 more source

Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui, Jiayang Zhan, Wei Li, Tao Jin, Dan He, Daishi Tian, Zhijun Li, Jing Lin, Yue Li, Hongyu Zhou, Bitao Bu   +10 more
wiley   +1 more source

Efficacy of sarilumab and dexamethasone co-administration for lowering multiple blood biomarkers in the treatment of cytokine release syndrome in hospitalized covid-19 patients

Journal of the Pakistan Medical Association
The current study was planned to explore the potential synergistic role of the co-administration of sarilumab and dexamethasone in reducing blood biomarkers associated with cytokine release syndrome in hospitalised patients of coronavirus disease-2019 ...
Ishtiaq Ahmad, Hamidullah
doaj   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Corticosteroids for dengue - why don't they work? [PDF]

, 2013
BACKGROUND: Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS: In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47 ...
Tuan Trung Vu, Cameron P. Simmons, Thi Hanh, Simmons, Cameron, Simmons, C, Tuan Trung Vu (496520), Thi Hoai, Martin L. Hibberd, Wills, B, Nguyen, Than Ha Quyen, Whitehead, SS, Martin L Hibberd, Dong, TH, Vu, TT, Phung, Khanh Lam, Stephen S. Whitehead, Bridget Wills (74672), Khanh Lam Phung, Wills, Bridget, Thi Hanh Tien Nguyen, Quyen Nguyen, Phung, KL, Van Ngoc Tran, Tien Nguyen, Van Ngoc Tran (496523), Farrar, J, Ngoc Tran, Van, Farrar, Jeremy, Hoang, TL, Jeremy Farrar, Nguyen, TH, Ngoc Tran, V, Stephen S. Whitehead (150702), Dong, Thi Hoai Tam, Nguyen, Thi Hanh Tien, Than Ha Quyen Nguyen (496519), Wolbers, M, Thi Hoai Tam Dong (496522), Jeremy Farrar (74677), Vu, Tuan Trung, Simmons, CP, Thi Hoai Tam Dong, Tam Dong, Whitehead, Stephen S, Marcel Wolbers, Marcel Wolbers (33689), Simmons, Cameron P, Than Ha, Than Ha Quyen Nguyen, Stephen S Whitehead, Hibberd, ML, Wolbers, Marcel, Bridget Wills, Khanh Lam Phung (496524), Cameron P Simmons, Cameron P. Simmons (117211), Martin L. Hibberd (167212), Hoang, Truong Long, Hibberd, Martin L, Truong Long Hoang, Thi Hanh Tien Nguyen (496518), Truong Long Hoang (496521)   +61 more
core   +2 more sources

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA‐Brasil

Arthritis Care &Research, EarlyView.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada, Marcos Rafael N. Cavalcante, Itamar de Souza Santos, Márcio S. Bittencourt, Vandrize Meneghini, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor   +7 more
wiley   +1 more source

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

Scientific Reports
SARS-CoV-2 provokes devastating tissue damage by cytokine release syndrome and leads to multi-organ failure. Modeling the process of immune cell activation and subsequent tissue damage is a significant task.
Chiu Wang Chau, Alex To, Rex K. H. Au-Yeung, Kaiming Tang, Yang Xiang, Degong Ruan, Lanlan Zhang, Hera Wong, Shihui Zhang, Man Ting Au, Seok Chung, Euijeong Song, Dong-Hee Choi, Pentao Liu, Shuofeng Yuan, Chunyi Wen, Ryohichi Sugimura   +16 more
doaj   +1 more source

An early regulatory mechanism of hyperinflammation by restricting monocyte contribution

Frontiers in Immunology
Innate immune cells play a key role in inflammation as a source of pro-inflammatory cytokines. However, it remains unclear how innate immunity-mediated inflammation is fine-tuned to minimize tissue damage and assure the host’s survival at the early phase
Megumi Akiyama, Megumi Akiyama, Masashi Kanayama, Yoshihiro Umezawa, Toshikage Nagao, Yuta Izumi, Masahide Yamamoto, Toshiaki Ohteki   +7 more
doaj   +1 more source

Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - Redundancy or specificity of neuroimmunoendocrine modulators? [PDF]

, 2004
Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM.
Kopp, F. B., Isele, N. B., Cengic, N., Weber, M. M., Engelhardt, D., Spottl, G., Senaldi, G., Auernhammer, Christoph J., Dorn, F., Vlotides, G., Auernhammer, CJ;Kopp, FB;Vlotides, G;Dorn, F;Isele, NB;Spöttl, G;Cengic, N;Weber, MM;Senaldi, G;Engelhardt, D   +10 more
core   +1 more source