Results 51 to 60 of about 2,857,482 (280)

Secondary hemophagocytic lymphohistiocytosis versus cytokine release syndrome in severe COVID-19 patients.

, 2020
IMPACT STATEMENT: Severe COVID-19 associated pneumonia and acute respiratory distress syndrome has recently been described with life-threatening features of cytokine storm and loosely referred to as hemophagocytic lymphohistiocytosis (HLH) or macrophage ...
Chi, Jeffrey, Hakim, Nausheen N, Olazagasti, Coral, Liu, Johnson M   +3 more
core   +2 more sources

Special case of a patient in the blast phase of chronic myeloid leukemia successfully treated with tocilizumab during critical SARS-CoV-2 infection

Journal of International Medical Research, 2022
The medical care of patients with hematological malignancies who develop coronavirus disease 2019 (COVID-19) has been a major challenge during the current pandemic.
Amine Bouchlarhem, Ounci Es-saad, Leila Haddar, Oussama Lamzouri, Ghizlane Elaidouni, Hamza Mimouni, Houssam Bkiyar, Brahim Housni   +7 more
doaj   +1 more source

A systematic review on the effects of Echinacea supplementation on cytokine levels: Is there a role in COVID-19?

Metabolism Open, 2021
COVID-19 is the respiratory illness caused by the novel coronavirus, SARS-CoV-2. Cytokine storm appears to be a factor in COVID-19 mortality. Echinacea species have been used historically for immune modulation.
Monique Aucoin, Valentina Cardozo, Meagan D. McLaren, Anna Garber, Daniella Remy, Joy Baker, Adam Gratton, Mohammed Ali Kala, Sasha Monteiro, Cara Warder, Alessandra Perciballi, Kieran Cooley   +11 more
doaj   +1 more source

Superantigen Mediated Shock: A Cytokine Release Syndrome

Immunobiology, 1993
Treatment of animals with superantigens results in profound immunological changes. A major fraction of all peripheral T cells becomes activated in vivo. Subsequently, successive waves of cytokines are produced with TNF playing a central pathophysiologic role.
T, Miethke, C, Wahl, D, Regele, H, Gaus, K, Heeg, H, Wagner   +5 more
openaire   +2 more sources

IL1 Blockade May Ameliorate Cytokine Release Syndrome

, 2018
Targeting IL1 attenuates cytokine release syndrome (CRS) without affecting CAR T-cell antitumor activity.

core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Tocilizumab in Severe COVID-19 Pneumonia and Concomitant Cytokine Release Syndrome

European Journal of Case Reports in Internal Medicine, 2020
Younger patients with COVID-19 may experience an exaggerated immune response to SARS-CoV-2 infection and develop cytokine release syndrome (CRS), which may be life threatening.
Tom van Kraaij, Rémy Mostard, Sofia Ramiro, Cesar Magro Checa, Christel van Dongen, Eric HJ van Haren, Jacqueline Buijs, Robert Landewé   +7 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Effectiveness of Tocilizumab in a COVID-19 Patient with Cytokine Release Syndrome

European Journal of Case Reports in Internal Medicine, 2020
Cytokine release syndrome (CRS) is a systemic inflammatory response that can be triggered by many factors such as infections. CRS in patients with coronavirus disease 2019 (COVID-19) is life-threatening and can occur very rapidly after COVID-19 diagnosis.
Sadettin Uslu
doaj   +1 more source

Does Vitamin D Supplementation Reduce Cytokine Storm and Mortality in Geriatric Intensive Care Patients Diagnosed with COVID-19

Journal of Contemporary Medicine, 2022
Introduction: Coronavirus disease progresses from an asymptomatic stage to a fatal stage characterized by a cytokine storm. Therefore, treatment should focus on enhancing the patients’immune function and preventing cytokine release syndrome.
Yeliz Bilir, Fulya Çiyiltepe, Akın Bilir, Ayten Saracoğlu, Elif Bombacı, Kemal Tolga Saraçoğlu, Recep Demirhan   +6 more
doaj   +1 more source