Results 41 to 50 of about 2,857,482 (280)

Modern Approaches to the Diagnosis and Treatment of Cytokine Release Syndrome Following CAR T-Cell Therapy

Медицина и биотехнологии
Introduction. Oncological diseases remain one of the leading causes of mortality worldwide. CAR T-cell therapy has demonstrated high efficacy in the treatment of B-cell leukaemias, lymphomas, and multiple myeloma.
Alexander M. Tsurkan, Darya V. Shpakova, Tatyana V. Ulanova   +2 more
doaj   +1 more source

High Ferritin in a Critically ill COVID-19 Patient: The Calm before Cytokine Storm [PDF]

Journal of Clinical and Diagnostic Research, 2020
Corona Virus Disease of 2019 (COVID-19) is spreading throughout the world and the United States with confirmed cases in all 50 states. Cytokine Release Syndrome (CRS), or cytokine storm, is being increasingly reported with severe cases of COVID-19 ...
Safa Saki , Mustafa Salam Mawih
doaj   +1 more source

Cytokine release: A workshop proceedings on the state-of-the-science, current challenges and future directions [PDF]

, 2016
In October 2013, the International Life Sciences Institute - Health and Environmental Sciences Institute Immunotoxicology Technical Committee (ILSI-HESI ITC) held a one-day workshop entitled, “Workshop on Cytokine Release: State-of-the-Science, Current ...
Finco, D, Fort, Madeline M., Reichmann, G, Finco, Deborah, Helms, WS, Mitchell, JA, Reed, DM, Walker, Mindi, Walker, M, Parish, ST, Reichmann, Gabriele, Fort, MM, Grimaldi, C, Parish, Stanley T., Mitchell, Jane A., O'Lone, R, Ryan, PC, Piche, MS, Gliddon, Daniel, O’Lone, Raegan, Helms, Whitney S., Ryan, Patricia C., Harper, K, Harper, Kirsty, Reed, Daniel M., Stebbings, Richard, Grimaldi, Christine, Piche, Marie-Soleil, Stebbings, R, Gliddon, D   +29 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Atypical cytokine release syndrome induced by carboplatin: The first described case report

International Journal of Immunopathology and Pharmacology
Introduction Hypersensitivity reactions to carboplatin include type I reactions, mixed reactions, and delayed reactions. Case report We report a case of an atypical cytokine release syndrome induced by carboplatin in a patient with breast carcinoma ...
Maria Cruz Torres Górriz MD, PhD, Julian Borrás Cuartero MD, Anna Bosh Requena MD, Dah Tay Jang MD, Ernesto Enrique MD, PhD   +4 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Implications of a local overproduction of tumor necrosis factor-α in complex regional pain syndrome [PDF]

, 2011
Objective. To review the implications of a local overproduction of tumor necrosis factor-α for the pathogenesis and treatment of complex regional pain syndrome. Background.
Walker, S., Drummond, P.D.
core  

An interesting case of life-threatening COVID-19 pneumonia

Apollo Medicine, 2020
COVID-19 pneumonia requires intensive care unit admission in approximately 5% of patients. The treatment options are all experimental. We report a case of life-threatening COVID-19 pneumonia with cytokine release syndrome who had successful outcome with ...
Sudha Kansal, Aakanksha Chawla Jain, M S Kanwar, Avdhesh Bansal, Nikhil Modi, Athar Parvez Ansari, Roseleen Kaur Bali, Viny Kantroo, Rajesh Chawla   +8 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source