Results 31 to 40 of about 2,857,482 (280)

Cardiovascular Complications of Chimeric Antigen Receptor T-Cell Therapy: The Cytokine Release Syndrome and Associated Arrhythmias [PDF]

Journal of Immunotherapy and Precision Oncology, 2020
In recent years, cancer treatment has evolved, and new therapies have been introduced with significant improvement in prognosis. The immunotherapies stand out owing to their efficacy and remission rate. Chimeric antigen receptor (CAR) T-cell therapy is a
Cesar Clavijo Simbaqueba, Maria Patarroyo Aponte, Peter Kim, Anita Deswal, Nicolas L. Palaskas, Cezar Iliescu, Eiman Jahangir, Eric H. Yang, Raphael E. Steiner, Juan Lopez-Mattei   +9 more
doaj   +1 more source

Management of CAR T-cell Related Toxicities: What did the Learning Curve Teach us so Far?

Hematology/Oncology and Stem Cell Therapy, 2022
Chimeric antigen receptor T cell (CAR-T) therapy is an immunotherapy, which represents a therapeutic breakthrough in the treatment of B-cell malignancies and multiple myeloma. Since the first CAR T-cell approval in 2017, there have been five FDA approved
Hemant S. Murthy, Farah Yassine, Madiha Iqbal, Shaikha Alotaibi, Muhamad Alhaj Moustafa, Mohamed A. Kharfan-Dabaja   +5 more
doaj   +1 more source

Lymphocyte subsets and the role of Th1/Th2 balance in stressed chronic pain patients [PDF]

, 2007
Background: The complex regional pain syndrome (CRPS) and fibromyalgia (FM) are chronic pain syndromes occurring in highly stressed individuals. Despite the known connection between the nervous system and immune cells, information on distribution of ...
Beyer, Antje, Thiel, Manfred, Richter, Peter, Huge, Volker, Schelling, Gustav, Chouker, Alexander, Kaufmann, Ines, Eisner, Christoph   +7 more
core   +1 more source

Cytokine Release Syndrome: Dissecting Immune Responses and Exploring Novel Anti-cytokine Strategies in Syngeneic Mouse Models

, 2021
The aberrant release of inflammatory mediators often referred to as a cytokine storm or cytokine release syndrome (CRS), is a common and sometimes fatal complication in acute infectious diseases including Ebola, dengue, COVID-19 and influenza.
Nouveau, Lise Gilberte Francine
core   +1 more source

Enhanced release of elastase is not concomitant with increased secretion of granulocyte-activating cytokines in whole blood from patients with sepsis [PDF]

, 1994
Die Diskussion am Ende des Artikels wurde gelöscht (§137l UrhG).Background The proteolytic enzyme elastase released by granulocytes (polymorphonuclear leukocytes [PMN]) in high concentrations during sepsis causes degradation of essential plasma proteins,
Schildberg, Friedrich-Wilhelm, Wolfgang Ertel, Jochum, Marianne, Thiele, Volker, Jarrar, Doreid, Kenney, John, Faist, Eugen, Ertel, Wolfgang   +7 more
core   +1 more source

Cytokine patterns during dengue shock syndrome [PDF]

, 2003
Objective. To investigate the patterns of tumor necrosis factor-a (TNF-a), interleukin-1b (IL-1b), IL-6, interferon-c (IFN-c) and interleukin-1 receptor antagonist (IL-1Ra) during the course of dengue shock syndrome. Design. Prospective clinical study.
Hack, C. Erik, van der Meer, Jos W. M., Dolmans, Wil M. V., Suharti, Catharina, van Gorp, Eric C. M., Setiati, Tatty E., Djokomoeljanto, Robert   +6 more
core   +1 more source

COVID-19 cytokine storm: The anger of inflammation

, 2020
Patients with COVID-19 who require ICU admission might have the cytokine storm. It is a state of out-of-control release of a variety of inflammatory cytokines. The molecular mechanism of the cytokine storm has not been explored extensively yet.
Keshavarz, Mohsen, Farrokhi, Shokrollah, Nabipour, Iraj, Roozbeh, Jamshid, Mahmudpour, Mehdi   +4 more
core   +1 more source

Cytokine release syndrome: grading, modeling, and new therapy

Journal of Hematology & Oncology, 2018
Genetically modified T cells that express a chimeric antigen receptor (CAR) are opening a new frontier in cancer immunotherapy. CAR T cells currently are in clinical trials for many cancer types.
Delong Liu, Juanjuan Zhao
doaj   +1 more source

Supplementary Figure from Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell–Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19

, 2022
Supplementary Figure from Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell–Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR ...
Chakkapong Burudpakdee (11247636), Bruce L. Levine (15038832), Rawan Shraim (15042750), Robert B. Lindell (15042777), Regina Myers (15042753), Richard Aplenc (186465), Jessica Perazzelli (15042786), Stephan A. Grupp (4864036), David M. Barrett (15042792), Vanessa Gonzalez (15042768), Haley Newman (15042783), Michele P. Lambert (15042771), Scott Canna (15042756), Shannon L. Maude (6997433), Saar Gill (11587713), Simon F. Lacey (4510477), Carl H. June (15038835), Hamid Bassiri (15042759), Amanda M. DiNofia (15042765), Fang Chen (15042762), J. Joseph Melenhorst (15042780), David T. Teachey (15042795), Edward M. Behrens (12822362), Allison Barz Leahy (15042774), Caroline Diorio (15042747), Alix E. Seif (15042789)   +25 more
core   +4 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source