Results 121 to 130 of about 5,983,916 (374)

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

Cytokine-associated drug toxicity in human hepatocytes is associated signaling network dysregulation [PDF]

, 2009
Refer to Web version on PubMed Central for supplementary material.Idiosyncratic drug hepatotoxicity is a major problem in pharmaceutical development due to poor prediction capability of standard preclinical toxicity assessments and limited knowledge of ...
Ballif, Bart S. Hendriks, Benjamin D. Cosgrove, Bylesjö, Chokki, Clayton, Cosgrove, Cosgrove, Deng, Deng, Deng, Douglas A. Lauffenburger, Fielden, Ganey, Gaudet, Geladi, Gunawan, Hatano, Hotamisligil, Janes, Janes, Janes, Janes, Kaplowitz, Kaplowitz, Kemp, Kim, Kolls, Kumar, Kumar, Le, Lee, Leonidas G. Alexopoulos, Linda G. Griffith, Malhi, McCubrey, Miller-Jensen, Ono, Peter K. Sorger, Saez-Rodriguez, Sarbassov, Schwabe, Shaw, Ta-chun Hang, Tacke, Tukov, Wajant, Wold, Xu, Xu, Yuan   +50 more
core   +1 more source

Deconvoluting global cytokine signaling networks in natural killer cells

Nature Immunology, 2021
G. Wiedemann, Endi K. Santosa, S. Grassmann, Sam Sheppard, Jean-Benoît Le Luduec, Nicholas M. Adams, Celeste Dang, K. Hsu, Joseph C. Sun, Colleen M. Lau   +9 more
semanticscholar   +1 more source

Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signaling

Nature Communications, 2014
Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high ARID1A mutation rates. Here we present a mutant mouse model of OCCC.
R. Chandler, J. Damrauer, Jesse R. Raab, J. Schisler, M. Wilkerson, John P. Didion, J. Starmer, D. Serber, D. Yee, J. Xiong, David B. Darr, F. Pardo-Manuel de Villena, William Y. Kim, T. Magnuson   +13 more
semanticscholar   +1 more source

Cytokines and JAK–STAT Signaling

Experimental Cell Research, 1999
Characterization of the ability of IFNs to induce immediate early genes led to the identification of the STAT (signal transducers and activators of transcription) signaling paradigm. STATs are activated at the receptor and then directly transduce signals to the nucleus.
openaire   +2 more sources

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis

OncoImmunology, 2017
The cytokine-induced SH2-containing protein CIS belongs to the suppressor of cytokine signaling (SOCS) protein family. Here, we show the critical role of CIS in suppressing natural killer (NK) cell control of tumor initiation and metastasis.
Eva M. Putz, Camille Guillerey, Kevin Kos, Kimberley Stannard, Kim Miles, Rebecca B. Delconte, Kazuyoshi Takeda, Sandra E. Nicholson, Nicholas D. Huntington, Mark J. Smyth   +9 more
doaj   +1 more source

Confocal laser scanning microscope, raman microscopy and western blotting to evaluate inflammatory response after myocardial infarction [PDF]

, 2015
Cardiac muscle necrosis is associated with inflammatory cascade that clears the infarct from dead cells and matrix debris, and then replaces the damaged tissue with scar, through three overlapping phases: the inflammatory phase, the proliferative phase
Cantatore, S, De Carlo, D, Fineschi, Vittorio, Fiore, C, Neri, M, Riezzo, I, Turillazzi, E   +6 more
core   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health

Cells
Chronic inflammation is increasingly recognized as a critical factor in female reproductive health; influencing natural conception and the outcomes of assisted reproductive technologies such as in vitro fertilization (IVF).
Efthalia Moustakli, Sofoklis Stavros, Periklis Katopodis, Charikleia Skentou, Anastasios Potiris, Periklis Panagopoulos, Ekaterini Domali, Ioannis Arkoulis, Theodoros Karampitsakos, Eleftheria Sarafi, Theologos M. Michaelidis, Athanasios Zachariou, Athanasios Zikopoulos   +12 more
doaj   +1 more source