Results 41 to 50 of about 5,759,209 (333)

Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations

Arthritis Research & Therapy, 2019
BackgroundThe in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the cellular level.MethodsPeripheral blood mononuclear cells from healthy donors were ...
I. McInnes, Nicole L. Byers, R. Higgs, Jonathan Lee, W. Macias, S. Na, R. Ortmann, G. Rocha, Terence Rooney, T. Wehrman, Xin Zhang, S. Zuckerman, P. Taylor   +12 more
semanticscholar   +1 more source

Targeting Cytokine Signaling and Lymphocyte Traffic via Small Molecules in Inflammatory Bowel Disease: JAK Inhibitors and S1PR Agonists

Frontiers in Pharmacology, 2019
The inflammatory Bowel diseases (IBDs) are a chronic, relapsing inflammatory diseases of the gastrointestinal tract with heterogeneous behavior and prognosis. The introduction of biological therapies including anti-TNF, anti-IL-12/23, and anti-integrins,
T. Pérez-Jeldres, C. Tyler, Joshua D. Boyer, Thangaraj Karuppuchamy, Andrés Yarur, Daniel A. Giles, Shaila Yeasmin, Luke R. Lundborg, W. Sandborn, Derek Patel, J. Rivera-Nieves   +10 more
semanticscholar   +1 more source

Expanded Hemodialysis ameliorates uremia-induced impairment of vasculoprotective KLF2 and concomitant proinflammatory priming of endothelial cells through an ERK/AP1/cFOS-dependent mechanism

Frontiers in Immunology, 2023
AimsExpanded hemodialysis (HDx) therapy with improved molecular cut-off dialyzers exerts beneficial effects on lowering uremia-associated chronic systemic microinflammation, a driver of endothelial dysfunction and cardiovascular disease (CVD) in ...
Hongfan Zhao, Dashan Wu, Michael Adu Gyamfi, Pinchao Wang, Christian Luecht, Anna Maria Pfefferkorn, Muhammad Imtiaz Ashraf, Julian Kamhieh-Milz, Janusz Witowski, Duska Dragun, Klemens Budde, Ralf Schindler, Daniel Zickler, Guido Moll, Guido Moll, Rusan Catar   +15 more
doaj   +1 more source

Structural Basis of IL-1 Family Cytokine Signaling

Frontiers in Immunology, 2019
Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli.
J. Fields, S. Günther, E. Sundberg
semanticscholar   +1 more source

Temporal Quantitative Phosphoproteomics Profiling of Interleukin-33 Signaling Network Reveals Unique Modulators of Monocyte Activation

Cells, 2022
Interleukin-33 (IL-33), a member of the IL-1 superfamily cytokines, is an endogenous danger signal and a nuclear-associated cytokine. It is one of the essential mediators of both innate and adaptive immune responses.
Devasahayam Arokia Balaya Rex, Yashwanth Subbannayya, Prashant Kumar Modi, Akhina Palollathil, Lathika Gopalakrishnan, Yashodhar P. Bhandary, Thottethodi Subrahmanya Keshava Prasad, Sneha M. Pinto   +7 more
doaj   +1 more source

SUN-309 Cytokine Signaling by Thyronine and NAD in Colon and Pancreas - Case reports Highlighting Stem Cell Differentiation and Insulin Regulation [PDF]

J Endocr Soc
Timothy Bilash
europepmc   +3 more sources

Targeting cytokine and chemokine signaling pathways for cancer therapy

Signal Transduction and Targeted Therapy
Cytokines are critical in regulating immune responses and cellular behavior, playing dual roles in both normal physiology and the pathology of diseases such as cancer.
Ming Yi, Tianye Li, Mengke Niu, Haoxiang Zhang, Yuze Wu, Kongming Wu, Zhi-tang Dai   +6 more
semanticscholar   +1 more source

TRAF Regulation of IL-17 Cytokine Signaling

Frontiers in Immunology, 2019
Tumor necrosis factor receptor (TNFR)-associated factors or (TRAFs) are important mediators of Interleukin-17 (IL-17) cytokine signaling and contribute to driving tissue responses that are crucial for protective immunity but are often implicated in ...
S. Swaidani, Caini Liu, Junjie Zhao, K. Bulek, Xiaoxia Li   +4 more
semanticscholar   +1 more source

3’UTR of SARS-CoV-2 spike gene hijack host miR-296 or miR-520h to disturb cell proliferation and cytokine signaling

Frontiers in Immunology, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has becoming globally public health threat. Recently studies were focus on SARS-CoV-2 RNA to design vaccine and drugs.
Jinjin Yuan, Ziheng Feng, Qiaowen Wang, Lifen Han, Shenchan Guan, Lijuan Liu, Hanhui Ye, Lili Xu, Xiao Han, Xiao Han   +9 more
doaj   +1 more source

Dysregulated peripheral proteome reveals NASH-specific signatures identifying patient subgroups with distinct liver biology

Frontiers in Immunology, 2023
Background and aimsNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. The prognosis may vary from simple steatosis to more severe outcomes such as nonalcoholic steatohepatitis (NASH), liver cirrhosis, and hepatocellular ...
Natalie Stiglund, Hannes Hagström, Hannes Hagström, Per Stål, Per Stål, Martin Cornillet, Niklas K. Björkström   +6 more
doaj   +1 more source