Results 61 to 70 of about 5,983,769 (231)

Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy

Cancer Science, 2017
Inhibition of immune checkpoint molecules, PD‐1 and CTLA4, has been shown to be a promising cancer treatment. PD‐1 and CTLA4 inhibit TCR and co‐stimulatory signals.
S. Chikuma, M. Kanamori, S. Mise-Omata, A. Yoshimura   +3 more
semanticscholar   +1 more source

The cytokine network in acute myeloid leukemia

Frontiers in Immunology, 2022
Acute myeloid leukemia (AML) is a highly heterogeneous malignancy of the blood and bone marrow, characterized by clonal expansion of myeloid stem and progenitor cells and rapid disease progression.
Michela Luciano, Michela Luciano, Peter W. Krenn, Peter W. Krenn, Jutta Horejs-Hoeck, Jutta Horejs-Hoeck   +5 more
doaj   +1 more source

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling [PDF]

, 2008
The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases. Here we found that MSK1 and MSK2 were needed to limit the production of proinflammatory cytokines in response to stimulation of primary ...
A Cuenda, A Soloaga, A Sommer, Andrew Wingate, B Echtenacher, B Echtenacher, BG Stiles, C Platzer, CA Gogos, Claire E Monk, Claus Johansen, D Rittirsch, DM Dambach, ER Ottosen, F Hildebrand, FY Liew, GR Wiggin, GY Song, H Chi, J Bain, J Darragh, J Han, J Rouse, J Simon C Arthur, Jin Mo Park, JM Park, Joanne Darragh, Joanne McIlrath, JS Arthur, JS Arthur, Julia M Carr, KV Salojin, Lars Iversen, M Brook, M Hammer, M Saraiva, ML Steinhauser, MS Lee, NC Riedamann, NW Freshney, Olga Ananieva, OM Peck-Palmer, P Chen, PC Cheung, PJ Murray, Q Zhao, R Kuhn, Rachel Toth, SE Moreno, SJ O'Keefe, SM Miggin, SQ Latifi, Susana G Santos, T Kawai, T Lang, T van der Poll, VA Beardmore, VS Carl, WJ Hubbard, X Zhang, Y Kalechman, YJ Kang   +61 more
core   +3 more sources

Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment

Frontiers in Immunology, 2017
Suppressor of cytokine signaling (SOCS) proteins are major negative feedback regulators of cytokine signaling mediated by the Janus kinase (JAK)-signal transducer and activator of transcription signaling pathway. In particular, SOCS1 and SOCS3 are strong
Mengmeng Jiang, Wenwen Zhang, Pengpeng Liu, Wenwen Yu, Ting Liu, Jinpu Yu   +5 more
semanticscholar   +1 more source

Features of cytokine signaling forming T-helper immune response in COPD of varying severity

Russian Open Medical Journal, 2020
Introduction — Currently, chronic obstructive pulmonary disease (COPD) is a global public health problem. However, molecular mechanisms of the development of this pathology are still poorly understood.
Tatyana I. Vitkina, Karolina A. Sidletskaya   +1 more
doaj   +1 more source

Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1 [PDF]

, 2015
Suppressor of cytokine signalling 3 (SOCS3) is a potent inhibitor of pro-inflammatory pathways involved in atherogenesis and the development of neo-intimal hyperplasia (NIH), which contributes to the in-stent re-stenosis responsible for the failure of ...
Palmer, Timothy P., Yarwood, Stephen J.
core   +1 more source

Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

eLife, 2021
Interleukin-2 is a pleiotropic cytokine that mediates both pro- and anti-inflammatory functions. Immune cells naturally differ in their sensitivity to IL-2 due to cell type and activation state-dependent expression of receptors and signaling pathway ...
Caleb R Glassman, Leon Su, Sonia S Majri-Morrison, Hauke Winkelmann, Fei Mo, Peng Li, Magdiel Pérez-Cruz, Peggy P Ho, Ievgen Koliesnik, Nadine Nagy, Tereza Hnizdilova, Lora K Picton, Marek Kovar, Paul Bollyky, Lawrence Steinman, Everett Meyer, Jacob Piehler, Warren J Leonard, K Christopher Garcia   +18 more
doaj   +1 more source

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

eLife, 2017
Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza.
L. Kedzierski, M. Tate, A. Hsu, T. B. Kolesnik, E. Linossi, Laura F. Dagley, Zhaoguang Dong, Sarah Freeman, Giuseppe Infusini, M. Starkey, Nicola L. Bird, Simon M. Chatfield, J. Babon, N. Huntington, G. Belz, A. Webb, P. Wark, N. Nicola, Jianqing Xu, K. Kedzierska, P. Hansbro, S. Nicholson   +21 more
semanticscholar   +1 more source

Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer

Signal Transduction and Targeted Therapy, 2023
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment.
Chen Xue, Q. Yao, Xin-yu Gu, Qing-miao Shi, Xin Yuan, Qingfei Chu, Zhengyi Bao, Juan-fen Lu, Lan-Ju Li   +8 more
semanticscholar   +1 more source

A Generic Mechanism for Enhanced Cytokine Signaling via Cytokine-Neutralizing Antibodies. [PDF]

PLoS ONE, 2016
Enhancement or inhibition of cytokine signaling and corresponding immune cells responses are critical factors in various disease treatments. Cytokine signaling may be inhibited by cytokine-neutralizing antibodies (CNAs), which prevents further activation
Boris Shulgin, Gabriel Helmlinger, Yuri Kosinsky   +2 more
doaj   +1 more source