Results 131 to 140 of about 109,140 (300)
The advent of the cytokine storm
Immunology & Cell Biology, 2007 The term 'cytokine storm' is now used in popular culture as an explanation for the distinctly unpleasant feeling we all sense at the onset of flu. The expression certainly has common currency, with 21 000 Google hits 12 months ago and 55 000 at the time of writing this article.
openaire +3 more sources
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Self‐Accelerating Bimetallic Peroxide Nanozymes for Cascade‐Amplified Pyroptosis‐Immunotherapy
Advanced Science, EarlyView.Acidic tumor microenvironment‐responsive CuZnONPs enable triple‐combination therapy via self‐supplying H2O2, cascade nanozyme activities for ROS burst, and Zn2+‐activated pyroptosis, synergizing catalytic therapy with immunotherapy to convert cold tumors into hot ones.
Xuanyi Lu +9 more
wiley +1 more source
Advanced Science, EarlyView.This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai +9 more
wiley +1 more source
The evidence and the rationale for the use of honey as wound dressing [PDF]
, 2011 Although there are now several brands and types of honey wound-care products available as registered medical devices, there is little promotional advertising of honey products for wound care. The misconception that there is no evidence to support the use
Molan, Peter C.
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Biochemistry of cytokine storm
, 2023 Objectives. To research the biochemical mechanisms underlying the development of cytokine storm in order to establish the utility of specific cytokine testing and possible therapeutic targets in patients. Materials and Methods. A wide area of articles from PubMed, Medscape, NCBI, HINARI, Google Scholar databases, Oxford academic journals over the last ...
Jagbir Singh, A., Timercan, T.V.
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Advanced Science, EarlyView.Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao +25 more
wiley +1 more source
SARS-CoV Regulates Immune Function-Related Gene Expressions in Human Monocytic Cells [PDF]
, 2011 Background: Severe Acute Respiratory Syndrome (SARS) is characterized by acute respiratory distress (ARDS) and pulmonary fibrosis, and the monocyte/macrophage is the key player in the pathogenesis of SARS. Methods: In this study, we ...
Betty A. Wu-Hsieh +4 more
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Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu +6 more
wiley +1 more source
Oral feeding of minocycline attenuates glial activation and reductions of tau and drebrin in response to systemically injected cytokines [PDF]
, 2016 published_or_final_versio
Chang, RCC +4 more
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