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Cytokine Drizzle: The Rationale for Abandoning “Cytokine Storm”
Journal of the American College of Surgeons, 2021ABSTRACT Background: “Cytokine storm” has been used to implicate increased cytokine levels in the pathogenesis of serious clinical conditions. Similarities with Severe Acute Respiratory Syndrome Coronoavirus-2 (SARS CoV-2) and the 2012 Middle Eastern Respiratory Syndrome led early investigators to suspect a “cytokine ...
Allan E, Stolarski +3 more
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Cytokines in Cytokine Storm Syndrome
2019As the eponymous mediators of the cytokine storm syndrome, cytokines are a pleomorphic and diverse set of soluble molecules that activate or suppress immune functions in a wide variety of ways. The relevant cytokines for each CSS are likely a result of differing combinations of environmental triggers and host susceptibilities.
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Cytokine Storm Syndromes in Pediatric Patients
The Journal of Allergy and Clinical Immunology: In Practice, 2023Cytokine storm syndromes (CSS) represent a diverse group of disorders characterized by severe overactivation of the immune system. In the majority of patients, CSS arise from a combination of host factors, including genetic risk and predisposing conditions, and acute triggers such as infections.
Caroline Diorio +2 more
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Bacteria-Associated Cytokine Storm Syndrome
2019While viruses are considered the most common infectious triggers for cytokine storm syndromes (CSS), a growing list of bacterial pathogens, particularly intracellular organisms, have been frequently reported to be associated with this syndrome. Both familial and sporadic cases of CSS are often precipitated by acute infections.
Esraa M, Eloseily, Randy Q, Cron
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Criteria for Cytokine Storm Syndromes
In the past two decades, there has been a great deal of work aimed to devise diagnostic guidelines, classification criteria, and diagnostic scores for cytokine storm syndromes (CSSs). The most notable effort has been the large-scale multinational study that led to the development of the 2016 classification criteria for macrophage activation syndrome ...Francesca, Minoia, Angelo, Ravelli
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Cytokine Storm of Acute Necrotizing Encephalopathy
Pediatric Neurology, 2011Acute necrotizing encephalopathy is a rare, clinically distinct entity characterized by multiple, symmetric areas of edema and necrosis in the thalamus, cerebellum, brainstem, and white matter. It is postulated to arise from uncontrolled cytokine release during a febrile illness, and is most often seen in East Asia.
Sujay M, Kansagra, William B, Gallentine
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Predicting cytokine storms: it's about density
Blood, 2011Romer and colleagues in this issue of Blood report that the density of T cells during culture increases sensitivity to the CD28 cosignaling agent TGN1412, providing an improved means of predicting cytokine release syndrome (CRS).[1][1] CRS is a common clinical event with antibody therapies such ...
Matthew J, Frigault, Carl H, June
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Science, 2015
Lung Disease The innate immune response is poised to act quickly in the face of pathogenic invaders. However, this priming can incite a cytokine storm: excessive production of inflammatory cytokines that harm the host. Coon et al. now report that HECTD2, a ubiquitin E3 ligase, can degrade the anti-inflammatory protein PIAS1, enhancing this inflammatory
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Lung Disease The innate immune response is poised to act quickly in the face of pathogenic invaders. However, this priming can incite a cytokine storm: excessive production of inflammatory cytokines that harm the host. Coon et al. now report that HECTD2, a ubiquitin E3 ligase, can degrade the anti-inflammatory protein PIAS1, enhancing this inflammatory
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Autoinflammatory Contributors to Cytokine Storm
Cytokine Storm is a complex and heterogeneous state of life-threatening systemic inflammation and immunopathology. Autoinflammation is a mechanistic category of immune dysregulation wherein immunopathology originates due to poor regulation of innate immunity.openaire +2 more sources
Infectious Diseases in Clinical Practice, 2010
Allison Nazinitsky, Kenneth S. Rosenthal
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Allison Nazinitsky, Kenneth S. Rosenthal
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