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COVID-19 Pneumonia and Cytokine Storm Syndrome
Virus-associated cytokine storm syndrome (CSS) has been recognized for a long time and the classic viruses associated are the herpes viruses EBV, CMV, and HHV-8 as described in chapters IVa,b. In addition, pandemic viruses such as influenza, SARS, and MERS can result in severe CSS that might ultimately lead to severe acute respiratory distress syndromeopenaire +3 more sources
CD8+ T Cell Biology in Cytokine Storm Syndromes
Familial forms of hemophagocytic lymphohistiocytosis (HLH) are caused by loss-of-function mutations in genes encoding perforin as well as those required for release of perforin-containing cytotoxic granule constituent. Perforin is expressed by subsets of CD8+ T cells and NK cells, representing lymphocytes that share mechanism of target cell killing yetTakuya, Sekine +5 more
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Myeloid Cells in the Immunopathogenesis of Cytokine Storm Syndromes
2019Cytokine storm syndromes (CSS) are caused by a dysregulated host immune response to an inciting systemic inflammatory trigger. This maladaptive and harmful immune response culminates in collateral damage to host tissues resulting in life-threatening multisystem organ failure. Knowledge of the various immune cells that contribute to CSS pathogenesis has
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Tocilizumab in SARS-CoV-2 Patients with the Syndrome of Cytokine Storm: A Narrative Review
Reviews on Recent Clinical Trials, 2021Shanmugaraj Kulanthaivel +2 more
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Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes
Blood Reviews, 2021James T England +2 more
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