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Understanding Cytokines Part I: Physiology and Mechanism of Action
Biological Research For Nursing, 2000This is the first of a 2-part article on understanding cytokines. Cytokines are intercellular signaling proteins released from virtually all nucleated cells that influence growth and cellular proliferation in a wide range of tissues. Cytokines have immune modulating effects and are understood to control most of the physical and psychological symptoms ...
E. Corwin
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Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology
Cytokine & Growth Factor Reviews, 2015Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ). Both of them are released by monocytes/macrophages, dendritic cells and T lymphocytes in inflammatory situations and upon binding to their respective receptor complexes they signal ...
H. Hermanns
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Channelling inflammation: gasdermins in physiology and disease
Nature Reviews Drug Discovery, 2021 Gasdermins were recently identified as the mediators of pyroptosis — inflammatory cell death triggered by cytosolic sensing of invasive infection and danger signals.
Xing Liu, Shiyu Xia, Zhibin Zhang
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γδ T cells in tissue physiology and surveillance
Nature Reviews Immunology, 2020Julie C Ribot, Bruno Silva-Santos
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Cytokines in placental physiology
Advances in Neuroimmunology, 1991Recent studies have shown that the human placenta is a very complex organ with many properties (Petraglia et al., 1990c). It plays a very important role in the physiology of pregnancy. Among various functions, its hormonal production is one of the most relevant.
Angioni, S. +7 more
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SOCS: physiological suppressors of cytokine signaling
Journal of Cell Science, 2000ABSTRACT Cytokines regulate cellular behavior by interacting with receptors on the plasma membrane of target cells and activating intracellular signal transduction cascades such as the JAK-STAT pathway. Suppressors of cytokine signaling (SOCS) proteins negatively regulate cytokine signaling.
D L, Krebs, D J, Hilton
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Humoral regulation of physiological sleep: cytokines and GHRH
Journal of Sleep Research, 1999Interleukin‐1, tumour necrosis factor, and growth hormone releasing hormone form part of the humoral mechanisms regulating physiological sleep. Their injection enhances non‐rapid‐eye‐movement sleep whereas their inhibition reduces spontaneous sleep and sleep rebound after sleep deprivation.
J M, Krueger, F, Obál, J, Fang
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Physiological role of cytokines in the regulation of mammalian metabolism
Trends in Immunology, 2023The innate cytokine system is involved in the response to excessive food intake. In this review, we highlight recent advances in our understanding of the physiological role of three prominent cytokines, interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF), in mammalian metabolic regulation.
Axel de Baat +3 more
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The Role of Cytokines in Physiological Sleep Regulation
Annals of the New York Academy of Sciences, 2001Abstract: Several growth factors (GFs) are implicated in sleep regulation. It is posited that these GFs are produced in response to neural activity and affect input‐output relationships within the neural circuits where they are produced, thereby inducing a local state shift. These GFs also influence synaptic efficacy.
J M, Krueger +4 more
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The Cytokines: Physiological and Pathophysiological Aspects
1993Publisher Summary This chapter discusses the physiological and pathophysiological aspects of cytokines. Despite the fact that many of the molecules are described on the basis of a single biological function, several molecules subsequently turned out to be pleiotropic with a wide range of actions and target cells.
S W, Evans, J T, Whicher
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