Results 221 to 230 of about 65,506 (309)

Cellular Morphometric Analysis (CellMorph)—a comprehensive imaging‐based tool for quantifying cellular phenotype heterogeneity and dynamics across biological processes

The FEBS Journal, EarlyView.
CellMorph is a groundbreaking tool that allows researchers to analyze multiple features from single cells, including cell size and shape, cytosolic staining and subcellular texture, nuclear staining, and morphometry. By evaluating images from both bright‐field and fluorescence microscopy, it also tracks changes in living cells during key processes such
Henrique Quaiato de Oliveira, Solon Andrades da Rosa, Luiza Cherobini Pereira, Laura Boose de Mendonça, Juliete Scholl, Fabrício Figueiró, Thais Cardoso Bitencourt, Davi Piovesan Echevarria, João Luiz Aldinucci Buzzo, Jessica Boschini D'Agostin, Danieli Rosane Dallemole, Carolina Oliveira, Fernanda Simas, Fernanda Saez‐Calazans, Débora Santos‐Sousa, Guido Lenz, Eduardo C. Filippi‐Chiela   +16 more
wiley   +1 more source

Alginate encapsulated cell blocks improve diagnostic consistency and long term specimen integrity in routine pathological diagnostics and cancer research. [PDF]

Sci Rep
Borowczak J, Kula M, Gostomczyk K, Olejnik K, Drozd M, Kostrzewska-Poczekaj M, Jarmuż-Szymczak M, Wierzbicka M, Giefing M, Szylberg Ł, Marszałek A, Bodnar M.   +11 more
europepmc   +1 more source

Shikimate pathway disruption in yeast induces metabolite self‐assembly into toxic aggregates

The FEBS Journal, EarlyView.
In Saccharomyces cerevisiae, shikimate pathway disruption induces toxic metabolite assemblies. Deleting ARO4 plus phenylalanine (Phe) feeding causes Phenylalanine accumulation, lowers ARO3 activity, and triggers amyloid‐like fibril formation. Deleting ARO3 plus tyrosine (Tyr) feeding leads to Tyrosine buildup and similar fibril assembly.
Hanaa Adsi, Myra Gartner, Claris Simovich, Lihi Gershon, Alexander Brandis, Ehud Gazit, Dana Laor Bar‐Yosef   +6 more
wiley   +1 more source

Diagnostic challenges in biliary cytology of biliary inflammatory pseudotumor of the liver: A case report and a review of the literature. [PDF]

Med Int (Lond)
Higuchi Y, Kato T, Kurihara E, Toyama T, Fusegawa T, Ubukata M, Yoshizawa T, Imaizumi T, Suzuki A, Oshima M, Endo F, Matsumoto S, Hagiwara K, Otake Y, Sugihara S, Tani N, Imai Y.   +16 more
europepmc   +1 more source

Limited roles of the miR‐17‐92 cluster in the regulation of T‐cell apoptosis

The FEBS Journal, EarlyView.
The pro‐apoptotic protein BIM shapes T‐cell survival and function, but how it is regulated remains unclear. In a mouse model lacking direct miR‐17‐92:Bim interactions, we observed a moderate reduction in Th17 CD4+ T cells. BIM levels were modestly increased in double‐positive thymocytes and naive CD8+ T cells, but this did not affect overall T‐cell ...
Katharina Hoppe, Johannes Woelk, Julia Benz, Sarah Spoeck, William J. Olson, Andreas Villunger, Natascha Hermann‐Kleiter, Verena Labi   +7 more
wiley   +1 more source

Case Report: Clinicopathological findings of a cutaneous mast cell tumor in a young domestic meerkat (<i>Suricata suricatta</i>). [PDF]

Front Vet Sci
Castaman MG, Orlandi M, Baldin M, Massaro M, Ridolfi M, Zambelli M.   +5 more
europepmc   +1 more source

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

The FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal, Tomas Brom, Ivona Nečasová, Tomáš Janovič, Pavel Veverka, Naina Verma, Lukáš Uhrík, Lenka Hernychova, Ctirad Hofr   +8 more
wiley   +1 more source

A Multicenter Collaborative Survey of Peritoneal Lavage Cytology in Gastric Cancer Surgery: Interinstitutional Methodological Differences and Positive Rate. [PDF]

Ann Surg Open
Fujiya K, Tokunaga M, Tone K, Nakanishi K, Tanaka R, Sato S, Kitadani J, Kakiuchi Y, Nakayama I, Hato S, Nunobe S, Fujitani K, Kurokawa Y, Boku N, Yoshikawa T.   +14 more
europepmc   +1 more source

3D virtual histology demonstrates tumour connectivity in spread through air spaces (STAS) of non‐small cell lung cancer

Histopathology, EarlyView.
STAS‐positive lung nodules were analysed using histology, clinical CT, and synchrotron‐based μCT. μCT enables 3D spatial insights of STAS clusters which appear consistently connected to alveolar or vascular structures, suggesting non‐random distribution.
Giulia Saccomano, Francesco Brun, Fulvia Martellani, Cristina Bottin, Stefano Lovadina, Marina Troian, Maria Assunta Cova, Elisa Baratella   +7 more
wiley   +1 more source

Novel principles of molecular genetic mapping of the interphase genome of Drosophila melanogaster. [PDF]

G3 (Bethesda)
Khoroshko VA, Tsukanov AV, Evdokimova AA, Vatolina TY, Levitsky VG, Zhimulev IF.   +5 more
europepmc   +1 more source