Results 41 to 50 of about 33,093 (301)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analysis of reasons impairing the quality of cerebrospinal fluid cell slide centrifugal sedimentation examination method and its preventive measures

Chinese Journal of Contemporary Neurology and Neurosurgery, 2018
It is well known that cerebrospinal fluid (CSF) cell slide centrifugal sedimentation examination method is a very important technique for the etiological diagnosis of many central nervous system (CNS) diseases, especially for infectious diseases ...
Xiu-chu SU
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Computed tomography-guided fine-needle aspiration biopsy

São Paulo Medical Journal
The therapeutic and prognostic evaluation of malignant neoplasias depends largely upon a precise morphologic diagnosis. Several papers have focused on the importance of fine-needle aspiration under computed tomography guidance in the diagnosis of ...
Gilda da Cunha Santos, Sandra Regina Morini, Luzete Cristina Silva Granero, Rubens Chojniak, Adhemar Longatto Filho   +4 more
doaj   +1 more source

Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR. [PDF]

PLoS ONE, 2011
Endobronchial Ultrasound Guided Transbronchial Needle Aspiration (EBUS-TBNA) and Trans-esophageal Ultrasound Scanning with Fine Needle Aspiration (EUS-FNA) are important, novel techniques for the diagnosis and staging of non-small cell lung cancer (NSCLC)
Ronald van Eijk, Jappe Licht, Melanie Schrumpf, Mehrdad Talebian Yazdi, Dina Ruano, Giusi I Forte, Petra M Nederlof, Maud Veselic, Klaus F Rabe, Jouke T Annema, Vincent Smit, Hans Morreau, Tom van Wezel   +12 more
doaj   +1 more source

A New Cytological Technique

CYTOLOGIA, 1953
New methods of locating currents and static potentials in living tissues with the aid of vital staining have been reviewed. Some methods allow quantitative estimates about the distribution of preponderantly extracellular molecules and a few extra-cellular ions in the electronegative space, and preponderantly intra-cellular molecules and anions in the ...
Keller, Rudolph, Chiego, Bernard, Kreidl, Marianne   +2 more
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Rapid Cytological Diagnosis of Skin Diseases in the Family Physician's Office

South African Family Practice, 1995
No abstract available.
B. Amichai, M.H. Grunwald, C. Zirkin, E. Finkelstein, S. Halevy   +4 more
doaj   +1 more source

Challenges of ICC and FISH in the Field of Targeted Therapies from Cell Block to Smears

Journal of Molecular Pathology, 2021
In the era of personalized medicine, there is an increasing demand for comprehensive and complex diagnosis using minimally invasive techniques. Nowadays, it is mandatory to integrate biomarkers in the diagnostic process, as well as in the treatment and ...
Jose I. Echeveste, Tania Labiano, Eva Tejerina, Allan Argueta, Carlos de Andrea, Maria D. Lozano   +5 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source